Showing Protein Dual serine/threonine and tyrosine protein kinase (BMDBP01159)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01159 |
| Secondary Accession Numbers | None |
| Name | Dual serine/threonine and tyrosine protein kinase |
| Synonyms | Not Available |
| Gene Name | DSTYK |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATP binding |
| Specific Function | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 16 |
| Locus | Not Available |
| SNPs | DSTYK |
| Gene Sequence |
>2787 bp ATGGAGGGCGACGGGGTGCCGTGGGGCAGCGAGCCGGAGTCGGGTCCCGGCCCGGGAGGC GGCGGAGTGATCCGCGAGCTGTGCCGGGGCTTTGGTCGCTACCGCCGCTACCTGGGGCGC CTGCGGCAGAACCTGCGCGACACGCAGAAGTTCTTCCGCGACCTCAGGGGCTCGCAGCCC CGCGGCTGTCCCTCCTCCCCTGCGGAGGGCGGCGAGGCCGGGCGCGGCCCTGCCGGCGAT GTCGCCGCGACCGGGCTGCCGGCGGGCCAGCTGAGCTGCATTTCCTTCCCACCCAAGGAA GAGAAGCGCCTCCAGCAGATGGTGGACTGCCTGCCCTGCATCTTGATCCTCGGCCAGGAC TGCAGTGTCAAGTGCCAGCTGCTGAACCTGCTCTTGGGGGTGCAGGTGCTTCCCACCAAC AAGCTGGGCGGTGAGAACTGTAAGCTTCGGCGCCTCCGCTTCACCTATGGGACTCAGACT CGGGTCAGCCTGGCGCTCCCTGACCGGTACGAACTAGTGCACACGCTGGCTGCTCACCAG GGCACCTGGGAGACCGTCCCTGAGGAGGACCTAGAGGCGCGGGAGGACAGTGAGGATGCT GCCCGCGTTCTAGCCGAACTGGAGGTGACGATGCGCCATGCTCTCTTACAGGAAGTGGAC ATTGTGGTAGCACCGTGCCAAGGCCTCCGGCCCACAGTGGATGTTCTGAGTGACTTGGTG AATGATTTCTTGCCTGTGATAACCTATGCGCTCCACAAAGATGAACTCTCTGAGAGGGAT GAGCAAGAGCTTCAGGAAATCCGAAAGTATTTCTCCTTTCCCATATTCTTTTTCAAAGTG CCGAAGCTGGGCTCGGAGATAATTGACTCCTCCACTGAAAGAATGGAGAGTGAAAGATCG CCACTTCATCGACAGCTGACTGACCTGGGCTATCTGAGCAGCAGCCTCTGTAACTGTGGG GCCCCCGGCCAGGACACCAAAGCTCAGAGCATGTTGGTGGAGCAAAGTGAGAAGCTGAGA CACTTGAACACGTTTTCTCACCAGGTGCTGCAGACTCGCCTGGTGGACGCAGCCAAGGCC CTGAACCTGGTGCACTGCCGCTGCCTCGACATCTTCATTAACCAGGCTTTTGACATGCAG CGGGACCTGCAGATTACGCCCAAACGTCTGGAATACACTCGAAAAAAGGAGAATGAGCTG TACGAATCATTGATGAATATTGCCAACCGGAAGCAAGAGGAAATGAAGGACATGATCGTT GAGACTCTTAACACCATGAAGGAGGAACTTCTGGATGATGCTGCCAACATGGAGTTCAAA GATGTCATTGTCCCTGAGAATGGAGAACCAGTGGGCACCAGAGAGATCAAATGCTGCATC CGACAGATCCAGGAGCTCATCATTTCCCGGCTTAATCAAGCAGTGGCTAACAAGCTGATC AGCTCCGTGGATTACCTACGTGAGAGCTTCGTTGGAACCCTGGAACGGTGTCTGCAGAGC CTGGAGAAGTCTCAGGATGTCTCAGTTCACATCACCAGTAATTATCTCAAACAGATCTTA AATGCTGCCTATCATGTTGAAGTCACGTTTCACTCAGGGTCGTCAGTTACAAGGATGCTA TGGGAGCAAATCAAACAGATCATCCAGCGCATCACTTGGGTGAGCCCACCTGCCATCACA CTGGAGTGGAAGAGGAAGGTGGCCCAGGAAGCCATCGAGAGCCTCAGTGCCTCCAAGCTG GCCAAAAGCATTTGCAGCCAGTTCAGGACTCGGCTCAACAGTTCTCACGAGGCCTTTGCA GCTTCCTTGCGGCAGCTGGAAGCTGGCCACTCAGGCCGGTTGGAGAAAACTGAAGATCTA TGGCTGAAGGTTCGGAAAGATCATGCTCCCCGCCTGGCACGCCTTTCGCTGGAAAGCCGT TCTCTACAGGATGTCTTACTGCATCGTAAACCTAAACTGGGGCAGGAGCTGGGCCGGGGC CAGTACGGCGTGGTGTACCTGTGTGACAGCTGGGGGGGGCACTTCCCTTGTGCCCTCAAG TCGGTTGTCCCTCCAGATGAGAAGCACTGGAATGACCTCGCTTTGGAGTTCCACTACATG AGGTCTCTGCCAAAGCATGAGCGCTTGGTGGATCTGCACGGCTCCGTCATCGACTACAGC TACGGCGGTGGCTCCAGCATTGCCGTGCTGCTCATCATGGAGCGGCTGCACCGGGACCTC TACACGGGACTGAAGGCTGGGCTGGCCCTGGAGACCCGTTTGCAGATAGCCCTAGATGTT GTGGAGGGAATCCGCTTCCTGCACAGCCAGGGACTTGTCCACCGTGATGTCAAACTGAAA AATGTGCTGTTGGACAAGCAGAACCGTGCCAAGATCACGGACTTAGGATTCTGCAAGCCA GAGGCCATGATGTCAGGCAGCATTGTGGGGACGCCAATCCATATGGCCCCTGAGCTTTTC ACAGGGAAGTATGATAATTCCGTGGATGTCTACGCTTTTGGCATTCTCTTCTGGTATATC TGCTCAGGCTCTGTCAAGCTCCCTGAGGCATTTGAGAGGTGTGCCAGCAAAGACCATCTC TGGAACAATGTGCGGAGAGGGGCCCGTCCAGAACGCCTTCCTGTGTTTGATGAGGAGTGC TGGCAGCTGATGGAAGCCTGTTGGGATGGTGACCCCTCTCAGAGACCTCTCTTGGGCATT GTCCAGCCCATGCTCCAGGGCATCATGGACCGGCTATGCAAGTCACATTCTGAGAGGCCA AACAGAGGACTCGATGATTCTACTTGA |
| Protein Properties | |
| Number of Residues | 928 |
| Molecular Weight | 104804.0 |
| Theoretical pI | 6.83 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Dual serine/threonine and tyrosine protein kinase MEGDGVPWGSEPESGPGPGGGGVIRELCRGFGRYRRYLGRLRQNLRDTQKFFRDLRGSQP RGCPSSPAEGGEAGRGPAGDVAATGLPAGQLSCISFPPKEEKRLQQMVDCLPCILILGQD CSVKCQLLNLLLGVQVLPTNKLGGENCKLRRLRFTYGTQTRVSLALPDRYELVHTLAAHQ GTWETVPEEDLEAREDSEDAARVLAELEVTMRHALLQEVDIVVAPCQGLRPTVDVLSDLV NDFLPVITYALHKDELSERDEQELQEIRKYFSFPIFFFKVPKLGSEIIDSSTERMESERS PLHRQLTDLGYLSSSLCNCGAPGQDTKAQSMLVEQSEKLRHLNTFSHQVLQTRLVDAAKA LNLVHCRCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIV ETLNTMKEELLDDAANMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLI SSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRML WEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFA ASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRG QYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYS YGGGSSIAVLLIMERLHRDLYTGLKAGLALETRLQIALDVVEGIRFLHSQGLVHRDVKLK NVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYI CSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPSQRPLLGI VQPMLQGIMDRLCKSHSERPNRGLDDST |
| External Links | |
| GenBank ID Protein | AAY46409.1 |
| UniProtKB/Swiss-Prot ID | Q4TVR5 |
| UniProtKB/Swiss-Prot Entry Name | DUSTY_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | DQ054504 |
| GeneCard ID | DSTYK |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |