| Identification |
|---|
| BMDB Protein ID
| BMDBP01161 |
| Secondary Accession Numbers
| |
| Name
| Protein kinase C beta type |
| Synonyms
|
Not Available
|
| Gene Name
| PRKCB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (By similarity). |
| Pathways
|
- BCR Signaling Pathway
- Cadmium Induces DNA Synthesis and Proliferation in Macrophages
- EGF Signalling Pathway
- GnRH Signaling Pathway
- Histamine H1 Receptor Activation
- Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
- Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
- Ion Channel and Phorbal Esters Signaling Pathway
- T Cell Receptor Signaling Pathway
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| PRKCB |
| Gene Sequence
|
>2022 bp
GCTCCGGCTCCCCGCGCGCAAGATGGCTGACCCGGCCGCGGGGCCGCCGCCGAGCGAGGG
AGAGGAGAGCACCGTGCGCTTCGCCCGCAAAGGCGCCCTCCGGCAGAAGAACGTGCACGA
GGTGAAGAACCACAAATTCACCGCCCGCTTCTTCAAGCAGCCCACCTTCTGCAGCCACTG
CACCGACTTCATCTGGGGCTTCGGGAAGCAAGGATTTCAGTGCCAAGTCTGCTGTTTTGT
CGTGCACAAGCGGTGCCATGAATTTGTCACCTTCTCCTGCCCGGGCGCTGACAAGGGCCC
AGCCTCTGACGACCCCCGGAGCAAACACAAGTTCAAGATCCACACATACTCCAGCCCCAC
GTTTTGTGACCACTGTGGGTCATTGCTCTATGGACTTATCCACCAGGGGATGAAATGTGA
CACCTGCATGATGAACGTCCACAAGCGCTGCGTGATGAACGTCCCCAGCCTCTGCGGCAC
GGACCACACGGAGCGCCGCGGCCGCATCTACATCCAAGCCCACATCGAGAGGGAGGTCCT
CATTGTTGTCGTAAGAGATGCTAAAAACCTTGTACCTATGGATCCTAATGGCTTGTCAGA
TCCTTACGTGAAACTGAAACTGATTCCTGATCCCAAGAGTGAGAGCAAGCAGAAGACCAA
GACCATCAAGTGCTCCCTCAACCCCGAGTGGAACGAAACATTTAGATTCCAGCTGAAAGA
ATCGGACAAAGACAGGAGACTGTCTGTAGAGATTTGGGATTGGGATCTGACCAGCAGAAA
TGACTTCATGGGATCTTTGTCGTTTGGGATTTCTGAACTGCAGAAAGCTGGTGTTGATGG
CTGGTTTAAGTTACTGAGCCAGGAGGAAGGCGAGTACTTCAACGTGCCCGTGCCACCGGA
AGGCAGTGAGGGCAACGAGGAACTGCGACAGAAATTCGAGAGAGCCAAGATCGGTCCTGG
GCCCAAGACTCCTGAAGAAAAGACGACCAACACCATCTCCAAATTTGACAACAACGGCAA
CAGGGACCGGATGAAATTGACCGATTTTAACTTCCTGATGGTGCTGGGAAAAGGCAGCTT
TGGCAAGGTCATGCTCTCAGAGCGAAAAGGCACAGATGAGCTGTATGCTGTGAAGATCCT
GAAAAAGGACGTGGTCATCCAAGATGATGACGTGGAATGCACGATGGTGGAGAAGCGGGT
GCTGGCCCTGCCCGGGAAGCCGCCCTTCCTGACCCAGCTGCATTCCTGCTTCCAGACCAT
GGATCGCCTGTACTTTGTGATGGAGTATGTGAATGGTGGTGACCTCATGTACCACATCCA
GCAAGTGGGCCGGTTCAAGGAGCCTCACGCCGTATTTTACGCTGCAGAAATTGCCATCGG
TCTGTTCTTCTTGCAGAGCAAGGGCATCATTTACCGTGACCTGAAACTTGACAATGTGAT
GCTGGATTCCGAGGGCCACATCAAGATCGCTGATTTTGGCATGTGTAAGGAGAACATCTG
GGATGGGGTGACGACTAAGACCTTCTGCGGCACCCCAGACTACATCGCCCCCGAGATAAT
TGCTTATCAGCCCTATGGGAAGTCCGTGGATTGGTGGGCATTTGGCGTCCTGCTGTATGA
GATGTTGGCTGGGCAGGCACCGTTTGAAGGGGAGGACGAGGATGAACTCTTCCAGTCCAT
CATGGAACACAACGTGGCTTATCCGAAGTCCATGTCCAAGGAAGCTGTGGCCATCTGCAA
AGGGCTGATCACCAAACACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGTGAACGTGA
CATCAAAGAGCATGCATTTTTCCGGTATATTGACTGGGAGAAACTTGAACGCAAAGAGAT
TCAGCCCCCGTATAAGCCGAAAGCCTGTGGGCGAAATGCTGAAAACTTCGACCGATTTTT
CACCCGCCATCCACCAGTTCTAACACCTCCTGACCAGGAAGTCATCAGGAATATTGACCA
ATCAGAATTCGAAGGATTTTCCTTTGTTAACTCTGAATTTTT
|
| Protein Properties |
|---|
| Number of Residues
| 671 |
| Molecular Weight
| 76790.0 |
| Theoretical pI
| 7.02 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein kinase C beta type
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIEREVLIVVVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEE
LRQKFERAKIGPGPKTPEEKTTNTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLITKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFS
FVNSEFLKPEVKS
|
| External Links |
|---|
| GenBank ID Protein
| AAA30703.1 |
| UniProtKB/Swiss-Prot ID
| P05126 |
| UniProtKB/Swiss-Prot Entry Name
| KPCB_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M13974 |
| GeneCard ID
| PRKCB |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
