| Identification |
|---|
| BMDB Protein ID
| BMDBP01173 |
| Secondary Accession Numbers
| None |
| Name
| Mevalonate kinase |
| Synonyms
|
Not Available
|
| Gene Name
| MVK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis. |
| Pathways
|
- Isopentenyl diphosphate biosynthesis via mevalonate pathway
- Isopentenyl diphosphate from (R)-mevalonate: step 1/3
- Isoprenoid biosynthesis
- Steroid Biosynthesis
|
| Reactions
|
| Mevalonic acid + Adenosine triphosphate → Mevalonic acid-5P + ADP |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| MVK |
| Gene Sequence
|
>1191 bp
ATGTTGTCAGAAGTCCTGCTGGTGTCCGCTCCAGGGAAAGTCATTCTGCATGGAGAGCAT
GCCGTGGTCCATGGCAAGGTAGCACTAGCAGTGGCCTTGAACTTGAGAACATTTCTCCGG
CTTCAGCCCCACAGCAATGGGAGAGTGGGCCTCAACTTACCAAACATTGGCGTCAGGAGG
GCCTGGGACGTGGCCAGCCTTCAGCTGCTGGACACCAGCTTTCTGGGGCACGGTGACAGC
GCAGCGCTCACCGCGAAGCACGTGGAGAAGCTGAAGGAGGTGGCGGGCTTCCCCAAGGAC
TGTGTGGATCCTGAGCACCTGGCCGTGCTGGCCTTCCTCTACTTGTACCTGTCTATCTGC
CAGAGTCAGAGAGCCCTGCCCAGCCTGGACATCACTGTATGGTCGGAGCTGCCCACTGGG
GCCGGGCTGGGCTCCAGTGCCGCCTACTCCGTGTGTTTGGCAGCTGCCCTCCTGACCGCG
TGCGAGGAGATCCCAAACCCGCTGAAGGATGGGGAGGCTGCCGGCAGGTGGACCGAGGAG
AACTTGGAGTTAATTAACAAGTGGGCCTTCCAGGGGGAGAGGGTGATTCACGGGAACCCG
TCCGGAGTGGACAACGCCGTCAGCACCTGGGGAGGAGCACTCCGATACCAGCAAGGGAAG
ATTTCATCTTTAAAGAGGCCACCGGTTCTGAAGATCCTGCTGATCAACACCAAAGTGCCT
CGCAGCACCAAGGTCCTGGTGGCCAATGTCAGGAGCCGGCTACTGAAGTTCCCTGAGATC
GTGGCCCCTCTCCTGACCTCCATAGACGCCATCTCCCTGGAGTGCGAGCGGGTGCTGGGG
GAGATGGCGGCGGCCCCCACTCCAGAGCACTACCTCACGCTGGAGGAGCTCATCGACATG
AACCAGCACCATCTGAATGCCCTCGGTGTGGGCCATGCCTCGCTGGACCAGCTGTGCCAG
GTGACCACAGCCCACGGACTGCACAGCAAGCTCACTGGCGCGGGCGGCGGGGGCTGTGGC
ATCACGCTCCTCAGGCCAGATGTGGAGCGGCCGGCGGTAGAGGCCACGAAGCGGGCGCTG
AGCGGCTGTGGCTTTGACTGCTGGGAAACCAGCGTTGGTGCCCCCGGTGTCTCTGTCCAC
ACGGCCGCCTCCCTGGATGCCTCTGTCCAGCAAGGCCTGGACAGCCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 396 |
| Molecular Weight
| 42070.0 |
| Theoretical pI
| 6.79 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Mevalonate kinase
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR
AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC
QSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE
NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP
RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM
NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRAL
SGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL
|
| External Links |
|---|
| GenBank ID Protein
| AAX08849.1 |
| UniProtKB/Swiss-Prot ID
| Q5E9T8 |
| UniProtKB/Swiss-Prot Entry Name
| KIME_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020832 |
| GeneCard ID
| MVK |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
