| Identification |
|---|
| BMDB Protein ID
| BMDBP01184 |
| Secondary Accession Numbers
| None |
| Name
| Serine/threonine-protein kinase PLK4 |
| Synonyms
|
Not Available
|
| Gene Name
| PLK4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| PLK4 |
| Gene Sequence
|
>2682 bp
ATGGCGACCTGCATCGGAGAAAAGATCGAGGATTTTAGAGTTGGAAATCTGCTTGGTAAA
GGATCATTTGCTGGTGTTTATAGAGCTGAGTCCATTCACACTGGTTTGGAAGTTGCAATC
AAAATGATAGATAAGAAAGCCATGTACAAAGCTGGAATGGTACAGAGAGTCCAAAATGAG
GTGAAAATACATTGCCAATTGAAACATCCTTCTATCTTGGAGCTGTATAACTATTTTGAA
GATAACAATTATGTGTACCTAGTATTAGAAATGTGCCATAACGGAGAAATGAACAGGTAT
TTAAAAAACAGAAGAAAACCATTCTCAGAAAATGAAGCTCGACACTTCATGCACCAAATC
ATCACAGGAATGTTATATCTCCATTCACATGGTATATTACACCGGGACCTCACACTTTCT
AACCTCTTACTTACACGTAATATGAACATCAAGATTGCTGATTTTGGGCTGGCAGCTCAG
TTGAAAATGCCACATGAAAAGCACTATACATTATGTGGAACTCCTAATTACATTTCTCCA
GAAATTGCAACTCGAAGTGCACATGGACTTGAATCTGATATTTGGTCCTTGGGCTGTATG
TTTTATACGTTACTTATTGGGAGACCGCCTTTTGACACTGACACAGTCAAGAACACATTA
AATAAAGTAGTATTGGCAGATTATGAAATGCCAACTTTTTTGTCAAGAGAAGCCAAGGAC
CTTATTCACCAGTTACTTCGTAGAAATCCAGCAGATCGTTTAAGTCTGTCTTCAGTATTA
GATCATCCTTTTATGTCCCGAAATTCTTCAAAAAAAAGCAAGGATTTAGGAACTGTAGAA
GACTCGATTGATAGTGGACATGCCACAATTTCTACAGCAATTACAGCTTCTTCCAGTACC
AGTATAAGTGGTAGTTTATTTGACAGAAGACGACTTTTGATTGAACAGCCACTCCCAAAT
AAAATGACTATATTTCCAAAGAATAAAAATCCAAGTGATTTTTCTTCTTCAGGAGATGGA
ATCAGCTTTTATACTTCATGGGGCAATCAAGAACAAGAAACCAGTAATAGTGGAAGGGGA
AGAGTAATCCAAGAGGCAGAAGAAAGACCACATTCTCGATACCTTCGTAGAGCCCATTCG
TCTGATAGATCTGAGACTTCTCATGGTCAGTCTAGAGTGAAAACATACACAATGGAACGA
TGTTACTCAGCAGAAATGCTTTCAAAATCCAAACGATCAGGAGTGGAGGAAAATGAAAGA
TACTCACCCACAAACAACGATGCTAATATTTTTCACTTCTTTAAGGAAAAAACATCCAAT
AGTTCTGGATCTTTTGAAGGACCTGATAACAATCAAGCACTCTCCAATCATCTTTGTCCA
GGAAAAACTCCCTTTCCATTTCCTGAACAGACACCTCAGACTGAAATGGTGCAACAATGG
TTTGGGAATCTGCAAATAAATGATCCTTCTTGTGAACAAAGCAAGACTAGGGGTGTGGAG
CCACCGTTGGTCTATCAGAAGCGTACATTACGAAGCATTACATCTCCTTTGACTGCTTAT
AGGTTAAAACCAATCCGACAGAAAACCAAAAAGGCCGTGGTGAGCATACTTGATTCAGAG
GAGGTATGTGTGGAGCTTCTGAAGGATTATGCATCTCAAGAATATGTGAAAGAAGTTCTT
CAGATATCTAGTGACGGGAGTATGATCACTATTTATTATCCAAATGATGGAAGAGGTTTT
CTTCTTGCTGATAGACCACCCTCACCTACTGATAACATCAGTAGGTACAGTTTTGATAAT
TTACCAGAAAAGTACTGGCGAAAATATCAATATGCTTCCAGATTTGTACAGCTTGTAAGA
TCTAAATCTCCTAAAATTACTTATTTTACAAGATATGCTAAATGTGTTTTGATGGAGAAT
TCCCCTGGTGCTGATTTTGAGGTTTGGTTTTATGATGGAGCAAAGATACACAAAACAGAA
GATTTAATTCAGGTGATCGAAAAGACTGGCAGATCTTACACCTTAAAAGGTGAAAGTGAA
GTTAATAGCTTAAAAGAGGAGGTAAAAATGTATATGAACCATGCTAATGAGGGCCACCGT
ATTTGTTTAGCACTGGAATCCATAATTTCAGAAGAGGAAAAGAAAAGTGGAAGTGCTCCC
TTTTTCCCCATAATCGTAGGAAGAAGACCTAGTAGTACTAGTTCACCTAAGGCCTTAACA
CCTCCTCCTCCTGTGGATCCAAACTACCCAATGAGAGAGACACCATCTCTGAATAGAATG
ATCATAAATAGTGCTGCTTCTCCAAAACAGGCACCAGTACTTAATCCTCCTGTGGTTACA
AATGAAGGACTTGGCCTTATGGGTGCAGCTTCTGAAACAAACAGCTCTCCTAGAAGTCTT
AAAGATTGTCTCCCTAAATCAGCACAACTTTTGAAGTCTGTTTTTGTGAAAAATGTTGGT
TGGGCTACACAGTTAACTAGTGGAGCTGTGTGGGTTCAGTTTAATGATGGGTCCCAGTTG
GTCGTGCAGGCAGGAGTGTCTTCTATTAGTTATACATCACCAGATGGTCAAACAACTAGG
TATGGAGAAAATGAAAAATTACCAGAATACATCAAACAGAAATTACAGTGTCTTTCTTCC
ATCCTTTTGATGTTTTCTAATCCAACTCCTAGTTTTCATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 893 |
| Molecular Weight
| 100707.0 |
| Theoretical pI
| 8.84 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein kinase PLK4
MATCIGEKIEDFRVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE
VKIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRRKPFSENEARHFMHQI
ITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLAAQLKMPHEKHYTLCGTPNYISP
EIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSREAKD
LIHQLLRRNPADRLSLSSVLDHPFMSRNSSKKSKDLGTVEDSIDSGHATISTAITASSST
SISGSLFDRRRLLIEQPLPNKMTIFPKNKNPSDFSSSGDGISFYTSWGNQEQETSNSGRG
RVIQEAEERPHSRYLRRAHSSDRSETSHGQSRVKTYTMERCYSAEMLSKSKRSGVEENER
YSPTNNDANIFHFFKEKTSNSSGSFEGPDNNQALSNHLCPGKTPFPFPEQTPQTEMVQQW
FGNLQINDPSCEQSKTRGVEPPLVYQKRTLRSITSPLTAYRLKPIRQKTKKAVVSILDSE
EVCVELLKDYASQEYVKEVLQISSDGSMITIYYPNDGRGFLLADRPPSPTDNISRYSFDN
LPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCVLMENSPGADFEVWFYDGAKIHKTE
DLIQVIEKTGRSYTLKGESEVNSLKEEVKMYMNHANEGHRICLALESIISEEEKKSGSAP
FFPIIVGRRPSSTSSPKALTPPPPVDPNYPMRETPSLNRMIINSAASPKQAPVLNPPVVT
NEGLGLMGAASETNSSPRSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQL
VVQAGVSSISYTSPDGQTTRYGENEKLPEYIKQKLQCLSSILLMFSNPTPSFH
|
| External Links |
|---|
| GenBank ID Protein
| AAI33489.1 |
| UniProtKB/Swiss-Prot ID
| A2VDZ4 |
| UniProtKB/Swiss-Prot Entry Name
| PLK4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC133488 |
| GeneCard ID
| PLK4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
