| Identification |
|---|
| BMDB Protein ID
| BMDBP01187 |
| Secondary Accession Numbers
| None |
| Name
| Casein kinase II subunit alpha' |
| Synonyms
|
Not Available
|
| Gene Name
| CSNK2A2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| CSNK2A2 |
| Gene Sequence
|
>1053 bp
ATGCCCGGCCCGGCCGCGCGGAGCAGGGCCCGGGTCTACGCGGAGGTGAACAGCCTGAGG
AGCCGCGAGTACTGGGACTATGAAGCTCACGTCCCGAGCTGGGGTAATCAAGATGATTAC
CAGCTGGTTCGGAAACTTGGTCGAGGAAAGTATAGTGAAGTATTTGAGGCTATTAACATC
ACCAACAACGAGAGAGTGGTGGTAAAAATTCTCAAGCCAGTGAAGAAAAAGAAGATAAAA
CGAGAGGTTAAGATTCTGGAGAACCTTCGTGGTGGAACAAATATCATTAAGCTGATTGAC
ACTGTGAAGGACCCTGTGTCAAAGACACCAGCTTTGGTATTTGAATATATCAATAATACA
GATTTTAAGCAACTGTACCAGATCCTGACAGACTTTGATATCCGGTTTTATATGTATGAA
CTACTTAAAGCTCTGGATTACTGCCACAGCAAGGGAATCATGCACAGGGATGTGAAACCT
CACAATGTCATGATAGATCACCAGCAGAAAAAGCTGCGACTGATAGACTGGGGTCTGGCA
GAATTCTATCATCCCGCCCAGGAGTACAATGTCCGAGTGGCCTCCAGGTACTTCAAGGGA
CCAGAGCTCCTTGTGGACTATCAGATGTATGATTATAGCTTGGATATGTGGAGTTTGGGC
TGTATGTTAGCAAGCATGATCTTTCGAAAGGAGCCCTTCTTTCATGGACAGGATAACTAT
GACCAGCTTGTTCGCATTGCCAAGGTTCTGGGTACAGATGAGCTGTATGGGTATCTGAAG
AAGTATCACATAGACCTAGATCCGCACTTCAACGATATTCTGGGACAACATTCACGGAAA
CGCTGGGAAAATTTTATCCATAGTGAGAACAGACACCTCGTCAGCCCTGAGGCCCTGGAT
CTTCTGGACAAACTTCTGCGATATGACCATCAACAGAGACTGACTGCCAAAGAGGCCATG
GAGCACCCGTACTTCTACCCTGTGGTGAAGGAGCAGTCCCAGCCTTGTGCAGATAACGCT
GTACTTTCCAGTGGTCTCACGGCAGCCCGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 350 |
| Molecular Weight
| 41270.0 |
| Theoretical pI
| 8.99 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Casein kinase II subunit alpha'
MPGPAARSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI
TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT
DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA
EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGQDNY
DQLVRIAKVLGTDELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD
LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
|
| External Links |
|---|
| GenBank ID Protein
| BAA04567.1 |
| UniProtKB/Swiss-Prot ID
| P20427 |
| UniProtKB/Swiss-Prot Entry Name
| CSK22_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D17712 |
| GeneCard ID
| CSNK2A2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
