| Identification |
|---|
| BMDB Protein ID
| BMDBP01191 |
| Secondary Accession Numbers
| |
| Name
| Mitogen-activated protein kinase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| MAPK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. May play a role in the spindle assembly checkpoint (By similarity). Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2. |
| Pathways
|
Not Available
|
| Reactions
|
| ETS domain-containing protein Elk-1 → ETS domain-containing protein Elk-1 + Hydrogen phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| MAPK1 |
| Gene Sequence
|
>1083 bp
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGAC
GTGGGGCCGCGCTACACCAATCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGC
TCTGCTTATGACAATGTCAACAAAGTCCGAGTCGCCATCAAGAAAATCAGCCCTTTTGAG
CACCAGACGTACTGCCAGAGAACGCTGAGAGAGATAAAGATCTTACTGCGCTTCAGACAT
GAGAACATCATCGGAATCAATGACATTATTCGAGCACCGACCATCGAGCAGATGAAAGAT
GTGTATATAGTACAGGACCTCATGGAAACAGATCTCTACAAGCTCTTGAAGACGCAACAC
CTCAGCAACGACCACATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAGTATATT
CATTCAGCCAACGTGCTGCACCGTGACCTCAAACCTTCCAACCTGCTGCTCAACACCACC
TGCGATCTCAAGATCTGTGACTTTGGCTTGGCCCGTGTTGCAGATCCAGACCACGACCAC
ACAGGGTTCTTGACAGAGTACGTGGCCACTCGCTGGTACCGGGCTCCAGAAATCATGTTG
AATTCCAAGGGCTACACCAAGTCCATCGACATCTGGTCCGTCGGCTGCATCCTCGCGGAG
ATGCTCTCCAACAGGCCCATCTTCCCCGGGAAGCACTACCTTGACCAGCTGAACCACATT
CTGGGTATTCTTGGATCCCCGTCGCAGGAAGACCTGAATTGTATAATAAATTTAAAAGCT
AGAAACTACCTGCTCTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCG
AACGCGGACTCCAAAGCTCTGGATCTACTGGACAAAATGTTGACGTTCAACCCTCACAAG
AGGATCGAGGTGGAGCAGGCTCTGGCCCATCCTTACCTGGAGCAGTACTACGACCCGAGC
GATGAGCCCGTCGCCGAAGCACCCTTCAAGTTTGACATGGAATTGGATGACTTGCCCAAG
GAAAAGCTCAAAGAACTCATTTTTGAAGAGACTGCTCGATTCCAGCCGGGATACCGATCT
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 360 |
| Molecular Weight
| 41376.0 |
| Theoretical pI
| 6.99 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Mitogen-activated protein kinase 1
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPVAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
|
| External Links |
|---|
| GenBank ID Protein
| CAA78467.1 |
| UniProtKB/Swiss-Prot ID
| P46196 |
| UniProtKB/Swiss-Prot Entry Name
| MK01_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| Z14089 |
| GeneCard ID
| MAPK1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
