Showing Protein Mitogen-activated protein kinase 13 (BMDBP01201)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 metabolites
Identification
BMDB Protein ID BMDBP01201
Secondary Accession Numbers None
Name Mitogen-activated protein kinase 13
Synonyms Not Available
Gene Name MAPK13
Protein Type Enzyme
Biological Properties
General Function Involved in ATP binding
Specific Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells (By similarity).
Pathways
  • BCR Signaling Pathway
  • CD40L Signalling Pathway
  • EGF Signalling Pathway
  • EPO Signaling Pathway
  • FAS signaling pathway ( CD95 )
  • Fc Epsilon Receptor I Signaling in Mast Cells
  • GnRH Signaling Pathway
  • Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
  • Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
  • Succinate Signalling During Inflammation
  • T Cell Receptor Signaling Pathway
  • TNF/Stress Related Signaling
  • Toll-Like Receptor Pathway 1
  • Toll-Like Receptor Pathway 2
Reactions
Transcription factor AP-1 → Transcription factor AP-1 + Hydrogen phosphate details
Cyclic AMP-dependent transcription factor ATF-2 → Cyclic AMP-dependent transcription factor ATF-2 + Hydrogen phosphate details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 23
Locus Not Available
SNPs MAPK13
Gene Sequence 
>1101 bp
ATGAGCTTCACCCGGAAAAAGGGCTTCTACAAGCAGGACGTCAACAAGACCGCCTGGGAG
CTGCCCAAGACCTACGTGTCCCTGACGCACATAGGCAGCGGGGCCTACGGCTCAGTGTGC
TCAGCCATCGACAAGCGGTCAGGGGAGAAGGTGGCCATCAAGAAGCTGAGCCGGCCCTTC
CAGTCCGAGATCTTTGCCAAGCGGGCTTATCGGGAGCTGCTGCTGCTGAAACACATGCAG
CATGAAAACGTCATCGGGCTTCTGGATGTCTTCACCCCAGCCTCCTCCCTGCGCAACTTC
CATGACTTCTACCTGGTGATGCCCTTCATGCAGACGGACCTGCAGAAGATCATGGGGATG
GAGTTCAGTGAGGACAAGATCCAGTACCTTGTGTACCAGATGCTCAAGGGTCTTAAGTAC
ATCCACTCAGCTGGGGTCGTCCACAGGGACCTGAAGCCGGGCAACCTCGCTGTGAATGAG
GACTGTGAGCTGAAGATCTTGGATTTTGGGTTGGCACGGCATACGGATGTGGAGATGACG
GGTTACGTGGTGACCCGCTGGTACCGGGCCCCTGAGGTGATTCTCAGCTGGATGCATTAC
AATCAGACTGTGGACATCTGGTCTGTGGGCTGTATCATGGCAGAGATGCTGACAGGGAAG
ACGCTGTTCAAGGGGAAAGACTACCTGGACCAGCTGACCCAGATTCTGAAAGTGACCGGG
GTGCCGGGTGCAGAGTTTGTGCAGAAGCTCAATGACAAGGCGGCCAAATCCTACATCCAG
TCCCTGCCACAAAGCCCCAAAAAGGATTTCTCTCAGCTCTTCCCGCGTGCCAGCCCCCAG
GCCACAGACCTGCTGGAGAAGATGCTGGAGCTGGACGTGGACAAGCGCCTGACGGCCTCG
CAGGCCCTCGCCCACCCCTTCTTTGAGCCCTTCCGGGACCCTGAGGAGGAGACAGAGGCC
CAGCAGCCGCTCGAGGATTCCTTAGAACGCGAGAAACTCATAGTGGACGAATGGAAGCAG
CACATCTACAAGGAGATCGTGAACTTCAGCCCCATTGCCCGGAAGGACTCTCGGCGCCGG
AGTGGCATGAAGCTGCAGTGA
Protein Properties
Number of Residues 366
Molecular Weight 42229.0
Theoretical pI 8.9
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Mitogen-activated protein kinase 13
MSFTRKKGFYKQDVNKTAWELPKTYVSLTHIGSGAYGSVCSAIDKRSGEKVAIKKLSRPF
QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFHDFYLVMPFMQTDLQKIMGM
EFSEDKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHTDVEMT
GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG
VPGAEFVQKLNDKAAKSYIQSLPQSPKKDFSQLFPRASPQATDLLEKMLELDVDKRLTAS
QALAHPFFEPFRDPEEETEAQQPLEDSLEREKLIVDEWKQHIYKEIVNFSPIARKDSRRR
SGMKLQ
GenBank ID Protein AAI02320.1
UniProtKB/Swiss-Prot ID Q3T0N5
UniProtKB/Swiss-Prot Entry Name MK13_BOVIN
PDB IDs Not Available
GenBank Gene ID BC102319
GeneCard ID MAPK13
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available