| Identification |
|---|
| BMDB Protein ID
| BMDBP01201 |
| Secondary Accession Numbers
| None |
| Name
| Mitogen-activated protein kinase 13 |
| Synonyms
|
Not Available
|
| Gene Name
| MAPK13 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells (By similarity). |
| Pathways
|
- BCR Signaling Pathway
- CD40L Signalling Pathway
- EGF Signalling Pathway
- EPO Signaling Pathway
- FAS signaling pathway ( CD95 )
- Fc Epsilon Receptor I Signaling in Mast Cells
- GnRH Signaling Pathway
- Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
- Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
- Succinate Signalling During Inflammation
- T Cell Receptor Signaling Pathway
- TNF/Stress Related Signaling
- Toll-Like Receptor Pathway 1
- Toll-Like Receptor Pathway 2
|
| Reactions
|
| Transcription factor AP-1 → Transcription factor AP-1 + Hydrogen phosphate |
details
|
| Cyclic AMP-dependent transcription factor ATF-2 → Cyclic AMP-dependent transcription factor ATF-2 + Hydrogen phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 23 |
| Locus
| Not Available |
| SNPs
| MAPK13 |
| Gene Sequence
|
>1101 bp
ATGAGCTTCACCCGGAAAAAGGGCTTCTACAAGCAGGACGTCAACAAGACCGCCTGGGAG
CTGCCCAAGACCTACGTGTCCCTGACGCACATAGGCAGCGGGGCCTACGGCTCAGTGTGC
TCAGCCATCGACAAGCGGTCAGGGGAGAAGGTGGCCATCAAGAAGCTGAGCCGGCCCTTC
CAGTCCGAGATCTTTGCCAAGCGGGCTTATCGGGAGCTGCTGCTGCTGAAACACATGCAG
CATGAAAACGTCATCGGGCTTCTGGATGTCTTCACCCCAGCCTCCTCCCTGCGCAACTTC
CATGACTTCTACCTGGTGATGCCCTTCATGCAGACGGACCTGCAGAAGATCATGGGGATG
GAGTTCAGTGAGGACAAGATCCAGTACCTTGTGTACCAGATGCTCAAGGGTCTTAAGTAC
ATCCACTCAGCTGGGGTCGTCCACAGGGACCTGAAGCCGGGCAACCTCGCTGTGAATGAG
GACTGTGAGCTGAAGATCTTGGATTTTGGGTTGGCACGGCATACGGATGTGGAGATGACG
GGTTACGTGGTGACCCGCTGGTACCGGGCCCCTGAGGTGATTCTCAGCTGGATGCATTAC
AATCAGACTGTGGACATCTGGTCTGTGGGCTGTATCATGGCAGAGATGCTGACAGGGAAG
ACGCTGTTCAAGGGGAAAGACTACCTGGACCAGCTGACCCAGATTCTGAAAGTGACCGGG
GTGCCGGGTGCAGAGTTTGTGCAGAAGCTCAATGACAAGGCGGCCAAATCCTACATCCAG
TCCCTGCCACAAAGCCCCAAAAAGGATTTCTCTCAGCTCTTCCCGCGTGCCAGCCCCCAG
GCCACAGACCTGCTGGAGAAGATGCTGGAGCTGGACGTGGACAAGCGCCTGACGGCCTCG
CAGGCCCTCGCCCACCCCTTCTTTGAGCCCTTCCGGGACCCTGAGGAGGAGACAGAGGCC
CAGCAGCCGCTCGAGGATTCCTTAGAACGCGAGAAACTCATAGTGGACGAATGGAAGCAG
CACATCTACAAGGAGATCGTGAACTTCAGCCCCATTGCCCGGAAGGACTCTCGGCGCCGG
AGTGGCATGAAGCTGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 366 |
| Molecular Weight
| 42229.0 |
| Theoretical pI
| 8.9 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Mitogen-activated protein kinase 13
MSFTRKKGFYKQDVNKTAWELPKTYVSLTHIGSGAYGSVCSAIDKRSGEKVAIKKLSRPF
QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFHDFYLVMPFMQTDLQKIMGM
EFSEDKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHTDVEMT
GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG
VPGAEFVQKLNDKAAKSYIQSLPQSPKKDFSQLFPRASPQATDLLEKMLELDVDKRLTAS
QALAHPFFEPFRDPEEETEAQQPLEDSLEREKLIVDEWKQHIYKEIVNFSPIARKDSRRR
SGMKLQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI02320.1 |
| UniProtKB/Swiss-Prot ID
| Q3T0N5 |
| UniProtKB/Swiss-Prot Entry Name
| MK13_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102319 |
| GeneCard ID
| MAPK13 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
