| Identification |
|---|
| BMDB Protein ID
| BMDBP01207 |
| Secondary Accession Numbers
| None |
| Name
| cAMP-dependent protein kinase catalytic subunit alpha |
| Synonyms
|
Not Available
|
| Gene Name
| PRKACA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (By similarity). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (By similarity). |
| Pathways
|
- Activation of cAMP-dependent protein kinase, PKA
- GnRH Signaling Pathway
- Muscle/Heart Contraction
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| PRKACA |
| Gene Sequence
|
>1056 bp
ATGGGCAACGCCGCCGCCGCCAAGAAGGGCAGCGAGCAAGAAAGCGTGAAAGAGTTCTTA
GCCAAAGCCAAAGAAGATTTTCTTAAAAAATGGGAAAATCCTGCTCAGAACACAGCCCAC
TTGGATCAGTTTGAACGAATCAAGACCCTGGGTACGGGCTCCTTCGGGCGGGTGATGCTG
GTGAAGCACATGGAGACCGGGAACCACTACGCCATGAAGATCCTCGACAAACAGAAGGTG
GTGAAGCTGAAACAGATTGAGCACACCCTGAATGAGAAGCGCATCCTGCAGGCGGTCAAC
TTTCCGTTCCTTGTCAAACTCGAGTTCTCCTTCAAGGACAACTCAAATTTATACATGGTC
ATGGAGTACGTGCCCGGTGGGGAGATGTTCTCACACCTGCGACGGATCGGGAGGTTCAGT
GAGCCCCACGCACGCTTCTACGCCGCCCAGATTGTCCTGACCTTTGAGTACCTGCACTCG
CTTGATCTCATTTACCGGGACCTGAAGCCAGAGAACCTCCTCATCGACCAGCAGGGCTAC
ATTCAGGTGACAGACTTTGGTTTCGCCAAGCGTGTGAAAGGCCGCACCTGGACCTTGTGT
GGGACCCCTGAGTACTTGGCCCCCGAGATCATCCTGAGTAAAGGCTACAACAAAGCTGTG
GACTGGTGGGCCCTGGGGGTCCTCATCTACGAAATGGCCGCAGGCTACCCGCCCTTCTTT
GCCGACCAGCCCATCCAGATCTACGAGAAGATTGTCTCTGGGAAGGTGCGGTTTCCATCC
CACTTCAGCTCTGACTTGAAGGATCTGCTGCGCAACCTCCTACAAGTGGACCTCACCAAG
CGCTTTGGGAACCTCAAGAATGGGGTCAATGATATCAAGAACCACAAGTGGTTTGCCACA
ACTGACTGGATTGCCATCTACCAGAGGAAGGTGGAAGCTCCCTTCATACCAAAGTTTAAA
GGCCCTGGGGACACAAGTAACTTTGACGACTATGAGGAGGAAGAGATCCGAGTCTCTATC
AATGAGAAGTGTGGCAAGGAGTTTTCTGAGTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 351 |
| Molecular Weight
| 40620.0 |
| Theoretical pI
| 9.05 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>cAMP-dependent protein kinase catalytic subunit alpha
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML
VKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
|
| External Links |
|---|
| GenBank ID Protein
| CAA47627.1 |
| UniProtKB/Swiss-Prot ID
| P00517 |
| UniProtKB/Swiss-Prot Entry Name
| KAPCA_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X67154 |
| GeneCard ID
| PRKACA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
