| Identification |
|---|
| BMDB Protein ID
| BMDBP01213 |
| Secondary Accession Numbers
| None |
| Name
| Calcium/calmodulin-dependent protein kinase type II subunit beta |
| Synonyms
|
Not Available
|
| Gene Name
| CAMK2B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| CAMK2B |
| Gene Sequence
|
>1629 bp
ATGGCCACCACGGTGACTTGCACCCGCTTCACCGACGAGTACCAGCTCTACGAGGATATT
GGCAAGGGGGCTTTTTCTGTGGTCCGTCGCTGTGTCAAGCTCTGCACCGGCCATGAGTAC
GCGGCCAAGATCATCAACACCAAGAAGCTGTCAGCCAGAGATCACCAGAAGCTGGAGAGA
GAGGCTCGAATCTGCCGTCTCCTGAAGCATTCCAACATTGTGCGCCTCCATGACAGCATC
TCCGAGGAAGGTTTCCACTACCTGGTCTTCGATCTGGTCACTGGTGGGGAGCTCTTTGAG
GACATTGTGGCGAGAGAGTACTACAGTGAGGCGGACGCCAGTCACTGCATCCAGCAGATC
CTGGAGGCGGTTCTCCACTGCCACCAAATGGGGGTCGTCCACAGGGACCTCAAGCCCGAG
AACCTGCTCCTGGCCAGCAAGTGCAAAGGGGCTGCGGTGAAGCTGGCGGACTTCGGCCTG
GCCATCGAGGTGCAGGGGGACCAGCAGGCGTGGTTTGGGTTCGCTGGCACGCCGGGCTAC
CTGTCTCCAGAGGTCCTGCGCAAGGAGGCGTACGGCAAGCCGGTGGACATCTGGGCATGC
GGGGTGATCCTGTACATCCTGCTCGTGGGCTACCCACCCTTCTGGGACGAGGACCAGCAC
AAGCTGTACCAGCAGATCAAGGCCGGGGCCTACGATTTCCCGTCCCCTGAGTGGGACACG
GTCACTCCCGAAGCCAAAAACCTCATTAACCAGATGTTGACCATCAACCCCGCCAAGCGC
ATCATGGCACATGAGGCACTGAAGCACCCATGGGTCTGCCAACGCTCCACTGTGGCCTCC
ATGATGCACAGGCAGGAGACCGTGGAGTGCCTGAAAAAATTCAACGCTCGGAGGAAGCTC
AAGGGTGCGATCCTCACCACCATGCTGGCCACACGGAATTTCTCAGTGGGCAGACAGACC
ACCGCTCCGGCCACAATGTCCACCGCGGCCTCCGGCGCCACCATGGGGCTGGTGGAACAA
GCCAAGAGTTTACTCAACAAGAAAGCAGATGGAGTTAAGCCCCAGACGAATAGCACCAAA
AACAGTGCAGCTGCCACCAGCCCCAAGGGGACGCTTCCTCCAGCCGCCTTGGAGCCTCAA
ACCACCGTCATTCATAACCCAGTGGACGGGATCAAGGAGTCATCTGACAGCACCCACACC
ACCATAGAGGATGAAGACACAAAAGCGCGGAAGCAGGAGATCATCAAGATCACGGAGCAG
CTCATCGAGGCTGTCAACAATGGCGACTTCGAGGCCTACGCGAAAATCTGCGACCCAGGC
CTGACCTCGTTTGAGCCTGAAGCCCTGGGCAACCTGGTTGAAGGGATGGACTTCCACAGA
TTCTACTTCGAGAACTTGCTCGCCAAGAACAGCAAGCCAATCCACACAACCATCCTGAAC
CCGCACGTGCACGTCATCGGCGAGGATGCCGCCTGCATCGCCTACATCCGCCTCACGCAG
TATATCGACGGGCAAGGCCGGCCCCGCACCAGCCAGTCCGAGGAGACCCGTGTGTGGCAT
CGCCGAGACGGCAAGTGGCAGAATGTGCACTTCCACTGCTCGGGGGCGCCCGTGGCCCCG
CTGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 542 |
| Molecular Weight
| 60482.0 |
| Theoretical pI
| 7.32 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Calcium/calmodulin-dependent protein kinase type II beta chain
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLER
EARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT
VTPEAKNLINQMLTINPAKRIMAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKL
KGAILTTMLATRNFSVGRQTTAPATMSTAASGATMGLVEQAKSLLNKKADGVKPQTNSTK
NSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSTHTTIEDEDTKARKQEIIKITEQ
LIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILN
PHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAP
LQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI05211.1 |
| UniProtKB/Swiss-Prot ID
| Q3MHJ9 |
| UniProtKB/Swiss-Prot Entry Name
| KCC2B_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105210 |
| GeneCard ID
| CAMK2B |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
