| Identification |
|---|
| BMDB Protein ID
| BMDBP01225 |
| Secondary Accession Numbers
| None |
| Name
| Calcium/calmodulin-dependent protein kinase type II subunit delta |
| Synonyms
|
Not Available
|
| Gene Name
| CAMK2D |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor (By similarity). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| CAMK2D |
| Gene Sequence
|
>1467 bp
ATGGCTTCGACTACAACCTGCACCAGGTTCACGGACGAGTATCAGCTTTTCGAGGAGCTC
GGAAAGGGGGCATTCTCAGTGGTGAGAAGATGTATGAAAATCCCTACTGGACAAGAATAT
GCTGCCAAAATTATCAACACCAAAAAGCTTTCTGCTAGGGATCATCAGAAACTGGAAAGG
GAAGCTAGAATCTGCCGTCTTTTGAAGCACCCCAATATTGTGCGACTTCATGACAGCATA
TCAGAAGAGGGCTTCCATTACTTGGTGTTTGATTTAGTTACTGGCGGTGAACTGTTTGAA
GACATAGTGGCAAGAGAGTATTACAGTGAAGCTGATGCCAGTCATTGTATACAGCAGATT
CTAGAAAGTGTAAATCATTGTCACCTAAATGGCATAGTGCACAGGGATCTGAAGCCTGAG
AATTTGCTTTTAGCTAGCAAATCCAAGGGAGCAGCTGTGAAACTCGCCGACTTTGGCTTA
GCCATAGAAGTCCAAGGAGACCAGCAGGCGTGGTTTGGTTTTGCTGGTACACCTGGATAT
CTTTCTCCAGAAGTTTTACGTAAAGATCCTTATGGAAAGCCAGTGGATATGTGGGCATGC
GGAGTCATCCTCTACATTCTACTGGTTGGATATCCACCATTCTGGGATGAAGACCAACAC
AGACTCTACCAGCAGATCAAGGCTGGAGCTTATGACTTTCCGTCACCAGAGTGGGACACC
GTGACTCCTGAAGCCAAAGACCTCATCAATAAAATGCTTACTATCAACCCTGCCAAGCGC
ATCACGGCCTCAGAGGCACTGAAACACCCGTGGATCTGTCAACGTTCTACTGTTGCTTCC
ATGATGCACAGACAGGAGACTGTAGACTGCTTGAAGAAATTCAATGCGAGAAGAAAACTA
AAGGGTGCCATCTTGACCACTATGCTGGCTACGAGGAATTTTTCAGCCAAGAGTTTGTTG
AAGAAACCGGATGGAGTAAAGAAAAGGAAGTCCAGTTCGAGTGTTCAGATGATGGAGTCA
ACTGAGAGCTCAAATACAACAATTGAGGATGAAGACGTGAAAGCACGAAAGCAAGAGATT
ATCAAAGTCACTGAACAACTGATCGAAGCTATCAACAATGGGGACTTTGAAGCTTACACA
AAAATCTGTGACCCAGGCCTTACTGCTTTTGAACCCGAAGCTTTGGGTAATTTAGTGGAA
GGGATGGACTTTCATCGATTCTACTTTGAAAATGCTTTGTCCAAAAGCAATAAACCCATC
CACACCATCATCCTGAACCCTCATGTGCACCTGGTGGGCGACGATGCTGCCTGCATAGCG
TACATTAGGCTCACCCAGTACATGGATGGCAGTGGAATGCCAAAAACAATGCAGTCGGAA
GAGACACGTGTGTGGCACCGCCGGGATGGAAAGTGGCAGAACGTTCATTTTCATCGCTCG
GGGTCGCCAACAGTACCCATCAACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 488 |
| Molecular Weight
| 55293.0 |
| Theoretical pI
| 7.61 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Calcium/calmodulin-dependent protein kinase type II delta chain
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDT
VTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKL
KGAILTTMLATRNFSAKSLLKKPDGVKKRKSSSSVQMMESTESSNTTIEDEDVKARKQEI
IKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPI
HTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRS
GSPTVPIN
|
| External Links |
|---|
| GenBank ID Protein
| AAI05460.1 |
| UniProtKB/Swiss-Prot ID
| Q2HJF7 |
| UniProtKB/Swiss-Prot Entry Name
| KCC2D_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105459 |
| GeneCard ID
| CAMK2D |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
