| Identification |
|---|
| BMDB Protein ID
| BMDBP01226 |
| Secondary Accession Numbers
| None |
| Name
| Serine/threonine-protein kinase pim-1 |
| Synonyms
|
Not Available
|
| Gene Name
| PIM1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B, induces 14-3-3 protein binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells. Promotes brown adipocyte differentiation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 23 |
| Locus
| Not Available |
| SNPs
| PIM1 |
| Gene Sequence
|
>942 bp
ATGCTCTTGTCCAAAATCAACTCGCTTGCCCACCTGCGCGCCGCGCCCTGCAGCGACCTG
CACGCCACCAAGCTGGCGCCGGGCAAGGAGAAGGAGCCCCTGGAGTCGCAGTACCAGGTG
GGCCCGCTCCTGGGCAGTGGCGGCTTCGGCTCGGTGTACTCAGGCATCCGTGTCGCCGAC
AACTTGCCGGTGGCCATCAAGCACGTGGAGAAGGACCGGATTTCCGACTGGGGAGAGCTG
CCTAATGGCACCCGAGTGCCCATGGAAGTGGTTCTGCTGAAGAAGGTGAGCTCGGGCTTC
TCCGGCGTCATTAGGCTCCTGGACTGGTTCGAGAGGCCCGACAGTTTCGTCCTGATCCTG
GAGAGGCCGGAGCCGGTGCAAGACCTCTTCGACTTTATCACGGAAAGGGGGGCTCTGCAG
GAGGAGCTGGCCCGCAGCTTCTTCTGGCAGGTACTGGAGGCGGTGCGACACTGCCACGAC
TGCGGGGTGCTTCACCGCGACATCAAGGACGAGAACATCCTTATCGACCTCAATCGCGGC
GAGCTCAAGCTCATCGACTTCGGGTCGGGGGCGCTGCTCAAGGACACCGTCTACACGGAC
TTCGATGGGACCCGAGTGTATAGTCCTCCAGAGTGGATCCGCTATCATCGCTACCATGGC
AGGTCGGCAGCCGTCTGGTCTCTGGGGATCCTGCTGTATGACATGGTGTGCGGAGATATT
CCCTTTGAGCACGATGAGGAGATTGTCAGGGGCCAAGTTTTCTTCAGGCAGCGGGTCTCC
TCAGAGTGTCAACATCTCATTAGATGGTGCTTGGCCTTGAGACCATCAGATCGGCCAACC
TTCGAAGAAATCCAGAACCATCCGTGGATGCAAGACGTCCTCCTGCCCCAGGAAACTGCT
GAGATCCATCTCCACAGCCTGTCGCCAGGGCCCAGCAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 313 |
| Molecular Weight
| 35630.0 |
| Theoretical pI
| 5.89 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Proto-oncogene serine/threonine-protein kinase pim-1
MLLSKINSLAHLRAAPCSDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVAD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHDCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIVRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
|
| External Links |
|---|
| GenBank ID Protein
| AAF67200.1 |
| UniProtKB/Swiss-Prot ID
| Q9N0P9 |
| UniProtKB/Swiss-Prot Entry Name
| PIM1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| AF259078 |
| GeneCard ID
| PIM1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
