| Identification |
|---|
| BMDB Protein ID
| BMDBP01231 |
| Secondary Accession Numbers
| None |
| Name
| Tyrosine-protein phosphatase non-receptor type substrate 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SIRPA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in SH3 domain binding |
| Specific Function
| Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| SIRPA |
| Gene Sequence
|
>1521 bp
ATGGAGCCAGCCCGCCCGGCCCCCGGCCGCCTCAGGCCGCTGCTCTGCCTGCTGCTCGCC
GCGTCCAGCGCCTGGACAGGAGCGGCAGGTGACGGGGAGCTGCAGGTGATTCAGCCTGAG
AGGTCAGTGTCAGTTGCAGCAGGAGAGACGGCCACTCTGCACTGCACCGTGACCTCCCTG
CTCCCCGTGGGGCCCATCAAGTGGTTCAGGGGAACTGGGCCAGGTCGGGAGTTCATCTAC
AGTCAAAAAGAAGCTCCTTTCCCCCGAGTAACAAATGTTTCAGATGCCACAAAGAGAAAC
AACATGGACTTTTCCATCCGCATCAGTAACATCACCCCAGCAGACGCTGGTGTCTACCAC
TGTGTGAAGTTCCAGAAAGGAGAACATGGTGACGTGGAGTTTAAGTCTGGACCAGGCACT
CATCTCACTGTGAACGCCAAACCCTCTCCTCCCGTGGTATCCGGCCCTACAGTGAGGGCT
ACACCTGAGCAGACAGTGAACTTCACCTGCACATCCCACGGCTTCTCCCCCAGAAACATC
TCCCTGAAATGGTTCAAAAATGGCAATGAGCTCTCAGCCTCCCAGACCAGCGTGGACCCA
GAGGACGACAACGTTTCCTACAGCATCAACAGCACAACCAAAGTGCTGCTGGCCACGGGA
GACGTTCACTCCCAGGTCATCTGCGAGGTGGCCCACGTCACCCTGCAGGGGGGCCCTCCT
CTCCGTGGGACTGCCAACTTGTCCGAGACCATCCGAGTTCCACCCACCCTGGAGATTACC
AGGTCCCCGTCAGCTGGGAACCAGGTGAACGTCACCTGCCAGGTGAACAAGTTCTACCCC
CGGCACCTACAGCTGACCTGGCTGGAGAACGGAAACATGTCCCGAACGGAAGCAGCCTCA
GTCCTCGTAGAGAACAAGGACGGGACCTTTAACCAGACGAGCTGGCTCCTGGTGAACTCC
TCTGCCCACAGGGAGGCTGTGGTGCTCACCTGCCAGGTGGAGCACGACAGGCAGCCGGCG
GTCTCCAAAAACCATACCCTGGAGGTCTCTGCTCCCCAGAAGGACCAGGACACAGGTCAA
ACCCCTGGCCCGAATGACAACAACTGGACCAGCATCTTCATCGTGGTGGGCGTGGTGTGT
GCCTTGCTGGTGGCCCTGCTGATCGCAGCCCTCTACCTCCTCCGAATCAGACAGAACAAA
GCCAAGGGCTCCACTTCTTCTACAAGGCTGCACGAGCCCGAGAAGAACACCAGAGAAACA
ACTCTGATCCAAGACAACAATGACTTCACATATGCAGAACTGAACCTGCCCAAGGGGAAG
AAATCAACCCCCAAGGCCAATGAACCGAACAACCACACGGAGTATGCCAGCATTCAGGCC
CGCCCGCCACCTGTATCTGAGGACACCCTCACCTACGCTGACCTGGACATGGTCCACCTC
AACCGGACCCCCAAGCAGCCGGCCCCCAAGCCTGAGCCATCCTACTCAGAGTATGCCAGT
GTCCAGGTCCAGAGGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 506 |
| Molecular Weight
| 55093.0 |
| Theoretical pI
| 7.81 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Tyrosine-protein phosphatase non-receptor type substrate 1
MEPARPAPGRLRPLLCLLLAASNAWTGTAGDGELQVIQPERSVSVAAGETATLHCTVTSL
SPVGPIKWFKGTGPGREFIYSQKEAPFPRVTNVSDATKRNNMDFSIRISNITPADAGVYY
CVKFRKEERGDMEFKSGPGTHLTVSAKPSPPVLSGPTVRATPEQTVNFTCTSHGFSPRNI
SLKWFKNGNELSASQTSVDPEDNNVSYSINSTTKVLLATGDVHSQVICEVAHVTLQGGPP
LRGTANLSETIRVPPTLEITGSPSAGNQVNVTCQVNKFYPRHLQLTWLENGNMSRTEAAS
VFVENKDGTFNQTSWFLVNSSAHREAVVLTCQVEHDGQPAVSKNHTLEVSAPQKDQDTGQ
TPGPNDSNWTSIFIVVGVVCALLVALLIAALYLLRIRQNKAKGSTSSTRLHEPEKNTRET
TQIQDNNDITYADLNLPKGKKSTPKANEPNNHTEYASIQARPPPVSEDTLTYADLDMVHL
NRTPKQPAPKPEPSYSEYASVQVQRK
|
| External Links |
|---|
| GenBank ID Protein
| CAA71942.1 |
| UniProtKB/Swiss-Prot ID
| O46631 |
| UniProtKB/Swiss-Prot Entry Name
| SHPS1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Y11045 |
| GeneCard ID
| SIRPA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
