Showing Protein Tyrosine-protein phosphatase non-receptor type substrate 1 (BMDBP01231)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01231 |
| Secondary Accession Numbers | None |
| Name | Tyrosine-protein phosphatase non-receptor type substrate 1 |
| Synonyms | Not Available |
| Gene Name | SIRPA |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in SH3 domain binding |
| Specific Function | Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 13 |
| Locus | Not Available |
| SNPs | SIRPA |
| Gene Sequence |
>1521 bp ATGGAGCCAGCCCGCCCGGCCCCCGGCCGCCTCAGGCCGCTGCTCTGCCTGCTGCTCGCC GCGTCCAGCGCCTGGACAGGAGCGGCAGGTGACGGGGAGCTGCAGGTGATTCAGCCTGAG AGGTCAGTGTCAGTTGCAGCAGGAGAGACGGCCACTCTGCACTGCACCGTGACCTCCCTG CTCCCCGTGGGGCCCATCAAGTGGTTCAGGGGAACTGGGCCAGGTCGGGAGTTCATCTAC AGTCAAAAAGAAGCTCCTTTCCCCCGAGTAACAAATGTTTCAGATGCCACAAAGAGAAAC AACATGGACTTTTCCATCCGCATCAGTAACATCACCCCAGCAGACGCTGGTGTCTACCAC TGTGTGAAGTTCCAGAAAGGAGAACATGGTGACGTGGAGTTTAAGTCTGGACCAGGCACT CATCTCACTGTGAACGCCAAACCCTCTCCTCCCGTGGTATCCGGCCCTACAGTGAGGGCT ACACCTGAGCAGACAGTGAACTTCACCTGCACATCCCACGGCTTCTCCCCCAGAAACATC TCCCTGAAATGGTTCAAAAATGGCAATGAGCTCTCAGCCTCCCAGACCAGCGTGGACCCA GAGGACGACAACGTTTCCTACAGCATCAACAGCACAACCAAAGTGCTGCTGGCCACGGGA GACGTTCACTCCCAGGTCATCTGCGAGGTGGCCCACGTCACCCTGCAGGGGGGCCCTCCT CTCCGTGGGACTGCCAACTTGTCCGAGACCATCCGAGTTCCACCCACCCTGGAGATTACC AGGTCCCCGTCAGCTGGGAACCAGGTGAACGTCACCTGCCAGGTGAACAAGTTCTACCCC CGGCACCTACAGCTGACCTGGCTGGAGAACGGAAACATGTCCCGAACGGAAGCAGCCTCA GTCCTCGTAGAGAACAAGGACGGGACCTTTAACCAGACGAGCTGGCTCCTGGTGAACTCC TCTGCCCACAGGGAGGCTGTGGTGCTCACCTGCCAGGTGGAGCACGACAGGCAGCCGGCG GTCTCCAAAAACCATACCCTGGAGGTCTCTGCTCCCCAGAAGGACCAGGACACAGGTCAA ACCCCTGGCCCGAATGACAACAACTGGACCAGCATCTTCATCGTGGTGGGCGTGGTGTGT GCCTTGCTGGTGGCCCTGCTGATCGCAGCCCTCTACCTCCTCCGAATCAGACAGAACAAA GCCAAGGGCTCCACTTCTTCTACAAGGCTGCACGAGCCCGAGAAGAACACCAGAGAAACA ACTCTGATCCAAGACAACAATGACTTCACATATGCAGAACTGAACCTGCCCAAGGGGAAG AAATCAACCCCCAAGGCCAATGAACCGAACAACCACACGGAGTATGCCAGCATTCAGGCC CGCCCGCCACCTGTATCTGAGGACACCCTCACCTACGCTGACCTGGACATGGTCCACCTC AACCGGACCCCCAAGCAGCCGGCCCCCAAGCCTGAGCCATCCTACTCAGAGTATGCCAGT GTCCAGGTCCAGAGGAAGTGA |
| Protein Properties | |
| Number of Residues | 506 |
| Molecular Weight | 55093.0 |
| Theoretical pI | 7.81 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Tyrosine-protein phosphatase non-receptor type substrate 1 MEPARPAPGRLRPLLCLLLAASNAWTGTAGDGELQVIQPERSVSVAAGETATLHCTVTSL SPVGPIKWFKGTGPGREFIYSQKEAPFPRVTNVSDATKRNNMDFSIRISNITPADAGVYY CVKFRKEERGDMEFKSGPGTHLTVSAKPSPPVLSGPTVRATPEQTVNFTCTSHGFSPRNI SLKWFKNGNELSASQTSVDPEDNNVSYSINSTTKVLLATGDVHSQVICEVAHVTLQGGPP LRGTANLSETIRVPPTLEITGSPSAGNQVNVTCQVNKFYPRHLQLTWLENGNMSRTEAAS VFVENKDGTFNQTSWFLVNSSAHREAVVLTCQVEHDGQPAVSKNHTLEVSAPQKDQDTGQ TPGPNDSNWTSIFIVVGVVCALLVALLIAALYLLRIRQNKAKGSTSSTRLHEPEKNTRET TQIQDNNDITYADLNLPKGKKSTPKANEPNNHTEYASIQARPPPVSEDTLTYADLDMVHL NRTPKQPAPKPEPSYSEYASVQVQRK |
| External Links | |
| GenBank ID Protein | CAA71942.1 |
| UniProtKB/Swiss-Prot ID | O46631 |
| UniProtKB/Swiss-Prot Entry Name | SHPS1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | Y11045 |
| GeneCard ID | SIRPA |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |