Showing Protein Glucose-6-phosphate isomerase (BMDBP01246)
| Identification | |||||||||
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| BMDB Protein ID | BMDBP01246 | ||||||||
| Secondary Accession Numbers |
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| Name | Glucose-6-phosphate isomerase | ||||||||
| Synonyms | Not Available | ||||||||
| Gene Name | GPI | ||||||||
| Protein Type | Enzyme | ||||||||
| Biological Properties | |||||||||
| General Function | Carbohydrate transport and metabolism | ||||||||
| Specific Function | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). | ||||||||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||||||||
| Cellular Location | Not Available | ||||||||
| Gene Properties | |||||||||
| Chromosome Location | 18 | ||||||||
| Locus | 18q22-q24 | ||||||||
| SNPs | GPI | ||||||||
| Gene Sequence |
>1674 bp ATGGCCGCGCTCACCCAGAACCCGCAGTTCAAGAAACTGAAGACATGGTACGAGCAGCAC GGCTCTGACCTCAACTTGCGCCGCCTTTTCGAAGGAGACAGGGACCGCTTTAACCGCTTC AGCTTGAACCTCAACACCAACCATGGGCATATTCTGGTGGACTACTCCAAGAACCTGGTG ACGGAGACTGTGATGCAGATGCTGGTGGACGTGGCTAAGTCCAGGGGTGTGGAGGCCGCC CGGGAGCGCATGTTTACTGGTGAGAAGATCAACTTCACTGAGGATCGGGCTGTGCTGCAC GTGGCCCTTCGGAACCGATCAAACGCACCCATTTTGGTGGATGGTAAGGATGTGATGCCA GAGGTCAACAGAGTCCTGGAGAAGATGAAGTCTTTCTGCCAGCGTGTCCGGAGTGGTGAA TGGAAAGGGTACTCGGGCAAGGCCATCACGGACGTCATCAACATCGGTATTGGCGGCTCT GACCTGGGACCCCTCATGGTGACTGAATCCCTCAAGCCCTACTCTTCAGAAGGTCCCCGG GTCTGGTTTGTCTCCAACATTGACGGGACTCACATTGCCAAAACGCTGGCCACCCTGAAC CCCGAGTCCTCTCTCTTTATCATTGCCTCCAAGACCTTCACTACCCAGGAGACCATCACG AACGCAGAGACAGCGAAGGAGTGGTTTCTCCTGTCGGCCAAGGATCCTTCTGCAGTCGCG AAACACTTTGTTGCCCTGTCTACCAACACTGCCAAAGTGAAGGAGTTTGGAATTGATCCT CAAAACATGTTCGAGTTCTGGGATTGGGTGGGAGGCCGCTACTCGCTGTGGTCAGCCATC GGACTCTCCATTGCCCTGCACGTGGGATTTGACAACTTCGAGCAGCTGCTCTCAGGAGCT CACTGGATGGACCAGCACTTCCGCACAACGCCCCTGGAGAAGAACGCCCCCGTGCTGCTG GCTCTGCTGGGCATATGGTACATCAACTGCTTTGGGTGTGAGACGCACGCCATGCTGCCC TATGATCAGTACCTGCACCGCTTTGCTGCCTACTTCCAGCAGGGTGACATGGAGTCCAAT GGGAAGTACATCACCAAGTCTGGCACCCGCGTGAACTACCAGACGGGCCCCATTGTGTGG GGGGAGCCAGGGACCAATGGCCAGCACGCCTTCTACCAGCTCATCCACCAAGGTACCAAG ATGATACCCTGCGACTTCCTCATCCCGGTCCAGAGCCAGCACCCCATAAGGAACGGTTTG CATCACAAGATCCTCCTGGCCAACTTCTTGGCCCAGACTGAGGCCCTGATGAGGGGGAAG TCGACAGAGGAGGCCCGGAAGGAGCTACAGGCTGCTGGAAGGAGTCCAGAGGACTTTGAG AAGCTGTTGCCTCACAAGGTCTTTGAAGGAAATCGCCCGACCAACTCTATAGTGTTCACC AAACTCACGCCATTCATTCTTGGAGCCTTGATTGCCATGTATGAGCACAAGATCTTCGTT CAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCAG CTGGCTAAGAAAATTGAACCTGAGCTTGACGGGAGCAGCCCAGTGACTTCTCACGATTCT TCCACCAATGGGCTGATCAACTTCATCAAGCAGGAGCGAGAGGCCAGAAGCTAA |
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| Protein Properties | |||||||||
| Number of Residues | 557 | ||||||||
| Molecular Weight | 62855.0 | ||||||||
| Theoretical pI | 7.8 | ||||||||
| Pfam Domain Function | Not Available | ||||||||
| Signals |
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| Transmembrane Regions | Not Available | ||||||||
| Protein Sequence |
>Glucose-6-phosphate isomerase MAALTQNPQFKKLKTWYEQHGSDLNLRRLFEGDRDRFNRFSLNLNTNHGHILVDYSKNLV TETVMQMLVDVAKSRGVEAARERMFTGEKINFTEDRAVLHVALRNRSNAPILVDGKDVMP EVNRVLEKMKSFCQRVRSGEWKGYSGKAITDVINIGIGGSDLGPLMVTESLKPYSSEGPR VWFVSNIDGTHIAKTLATLNPESSLFIIASKTFTTQETITNAETAKEWFLLSAKDPSAVA KHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGA HWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESN GKYITKSGTRVNYQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQSQHPIRNGL HHKILLANFLAQTEALMRGKSTEEARKELQAAGRSPEDFEKLLPHKVFEGNRPTNSIVFT KLTPFILGALIAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSSPVTSHDS STNGLINFIKQEREARS |
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| External Links | |||||||||
| GenBank ID Protein | AAI03417.1 | ||||||||
| UniProtKB/Swiss-Prot ID | Q3ZBD7 | ||||||||
| UniProtKB/Swiss-Prot Entry Name | G6PI_BOVIN | ||||||||
| PDB IDs | |||||||||
| GenBank Gene ID | DAAA02046903 | ||||||||
| GeneCard ID | GPI | ||||||||
| GenAtlas ID | Not Available | ||||||||
| HGNC ID | Not Available | ||||||||
| References | |||||||||
| General References | Not Available | ||||||||