Showing Protein Glutathione S-transferase A1 (BMDBP01276)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01276 |
| Secondary Accession Numbers | None |
| Name | Glutathione S-transferase A1 |
| Synonyms | Not Available |
| Gene Name | GSTA1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in glutathione transferase activity |
| Specific Function | Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 23 |
| Locus | Not Available |
| SNPs | GSTA1 |
| Gene Sequence |
>669 bp ATGGCAGGGAAGCCCACTCTTCACTATTTCAATGGACGCGGCAGAATGGAGTGCATTCGG TGGCTCCTAGCTGCAGCTGGAGTGGAGTTTGAAGAGAAATTTATAGAAAAACCAGAAGAC TTGGATAAGTTAAAAAATGATGGGAGTTTGATGTTCCAGCAAGTGCCAATGGTTGAAATT GATGGGATGAAGCTGGTGCAGACCAGAGCCATTCTCAACTACATTGCCACCAAATACAAC CTCTACGGGAAAGACATGAAGGAGAGAGCCCTGATTGATATGTATTCAGAGGGTGTGGCA GATTTGGGTGAAATGATCATGCATTTTCCACTGTGCCCACCTGCTGAAAAAGATGCCAAG CTGACCCTAATCCGAGAAAAGACAACAAACCGTTATCTCCCTGCATTTGAAAATGTGCTG AAGAGCCATGGACAAGACTACCTGGTGGGCAACAAGCTGAGCAGGGCTGACATCCACTTG GTTGAACTTCTCTACTATGTGGAAGAGCTGGACCCCAGCCTTTTGGCCAACTTCCCTCTG CTAAAGGCCCTAAAAGCCAGAGTCAGCAGTCTCCCGGCTGTGAAGAAATTTCTGCAGCCT GGCAGCCAGAGGAAGCCTCCCACGGATGAGAAAAAAATAGAAGAAGCCAGGAAGGTTTTC AAGTTTTAG |
| Protein Properties | |
| Number of Residues | 222 |
| Molecular Weight | 25452.0 |
| Theoretical pI | 8.93 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Glutathione S-transferase A1 MAGKPTLHYFNGRGRMECIRWLLAAAGVEFEEKFIEKPEDLDKLKNDGSLMFQQVPMVEI DGMKLVQTRAILNYIATKYNLYGKDMKERALIDMYSEGVADLGEMIMHFPLCPPAEKDAK LTLIREKTTNRYLPAFENVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDPSLLANFPL LKALKARVSNIPAVKKFLQPGSQRKPPTDEKKIEEARKVFKF |
| External Links | |
| GenBank ID Protein | AAB72239.1 |
| UniProtKB/Swiss-Prot ID | Q28035 |
| UniProtKB/Swiss-Prot Entry Name | GSTA1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | U49179 |
| GeneCard ID | GSTA1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |