Showing Protein 26S proteasome regulatory subunit 8 (BMDBP01277)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01277 |
| Secondary Accession Numbers | None |
| Name | 26S proteasome regulatory subunit 8 |
| Synonyms | Not Available |
| Gene Name | PSMC5 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Posttranslational modification, protein turnover, chaperones |
| Specific Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 19 |
| Locus | Not Available |
| SNPs | PSMC5 |
| Gene Sequence |
>1221 bp ATGGCGCTTGACGGACCAGAGCAGATGGAGCTGGAAGAGGGGAAAGCAGGCAGTGGACTC CGCCAATATTATCTGTCCAAGATTGAAGAACTCCAGCTGATTGTGAATGATAAGAGCCAA AATCTCCGGAGGCTACAGGCACAGAGGAATGAGCTTAATGCAAAAGTTCGCCTGCTGCGG GAGGAGCTACAGCTGCTGCAGGAACAGGGCTCCTACGTGGGGGAAGTAGTCCGGGCCATG GATAAGAAAAAAGTGCTAGTCAAGGTACATCCGGAGGGCAAGTTTGTCGTCGACGTGGAC AAGAACATCGACATCAATGATGTGACACCCAATTGCCGGGTGGCCCTCAGAAATGATAGC TACACTCTGCACAAGATCCTGCCTAACAAGGTGGACCCGCTGGTGTCCCTGATGATGGTG GAGAAGGTGCCAGATTCAACTTACGAGATGATTGGTGGACTGGACAAACAGATCAAGGAG ATCAAAGAAGTGATTGAGCTGCCTGTGAAGCATCCTGAGCTGTTTGAAGCACTGGGCATC GCGCAGCCCAAGGGGGTACTGCTATACGGACCTCCGGGCACGGGGAAGACACTGCTGGCC CGGGCCGTGGCACATCATACAGACTGCACCTTCATTCGTGTGTCTGGCTCTGAATTGGTA CAGAAATTCATCGGGGAAGGGGCGCGGATGGTGAGGGAGCTGTTTGTCATGGCCCGAGAA CACGCTCCATCTATCATCTTCATGGATGAAATTGACTCCATTGGCTCCTCGAGGCTGGAG GGGGGCTCTGGAGGGGACAGTGAAGTCCAGCGCACTATGCTGGAGCTGCTCAACCAGCTG GATGGCTTTGAGGCCACCAAGAATATCAAGGTTATCATGGCAACCAATAGGATTGACATC CTAGACTCGGCGCTGCTCCGCCCAGGGCGCATAGACAGAAAAATTGAATTCCCACCCCCC AACGAGGAGGCCCGGCTGGACATTTTGAAGATCCATTCTCGGAAAATGAACCTGACCCGG GGGATCAACCTGAGAAAAATTGCTGAGCTCATGCCAGGAGCGTCAGGGGCTGAAGTGAAG GGCGTGTGCACCGAGGCTGGCATGTACGCGCTGCGGGAGCGCCGCGTCCACGTCACGCAG GAGGACTTTGAGATGGCAGTGGCTAAGGTCATGCAAAAGGACAGTGAGAAAAACATGTCC ATCAAGAAACTATGGAAGTGA |
| Protein Properties | |
| Number of Residues | 406 |
| Molecular Weight | 45626.0 |
| Theoretical pI | 7.66 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>26S protease regulatory subunit 8 MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLR EELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDS YTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGI AQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMARE HAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDI LDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVK GVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK |
| External Links | |
| GenBank ID Protein | AAC19266.1 |
| UniProtKB/Swiss-Prot ID | P62194 |
| UniProtKB/Swiss-Prot Entry Name | PRS8_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AF069053 |
| GeneCard ID | PSMC5 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |