| Identification |
|---|
| BMDB Protein ID
| BMDBP01277 |
| Secondary Accession Numbers
| None |
| Name
| 26S proteasome regulatory subunit 8 |
| Synonyms
|
Not Available
|
| Gene Name
| PSMC5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| PSMC5 |
| Gene Sequence
|
>1221 bp
ATGGCGCTTGACGGACCAGAGCAGATGGAGCTGGAAGAGGGGAAAGCAGGCAGTGGACTC
CGCCAATATTATCTGTCCAAGATTGAAGAACTCCAGCTGATTGTGAATGATAAGAGCCAA
AATCTCCGGAGGCTACAGGCACAGAGGAATGAGCTTAATGCAAAAGTTCGCCTGCTGCGG
GAGGAGCTACAGCTGCTGCAGGAACAGGGCTCCTACGTGGGGGAAGTAGTCCGGGCCATG
GATAAGAAAAAAGTGCTAGTCAAGGTACATCCGGAGGGCAAGTTTGTCGTCGACGTGGAC
AAGAACATCGACATCAATGATGTGACACCCAATTGCCGGGTGGCCCTCAGAAATGATAGC
TACACTCTGCACAAGATCCTGCCTAACAAGGTGGACCCGCTGGTGTCCCTGATGATGGTG
GAGAAGGTGCCAGATTCAACTTACGAGATGATTGGTGGACTGGACAAACAGATCAAGGAG
ATCAAAGAAGTGATTGAGCTGCCTGTGAAGCATCCTGAGCTGTTTGAAGCACTGGGCATC
GCGCAGCCCAAGGGGGTACTGCTATACGGACCTCCGGGCACGGGGAAGACACTGCTGGCC
CGGGCCGTGGCACATCATACAGACTGCACCTTCATTCGTGTGTCTGGCTCTGAATTGGTA
CAGAAATTCATCGGGGAAGGGGCGCGGATGGTGAGGGAGCTGTTTGTCATGGCCCGAGAA
CACGCTCCATCTATCATCTTCATGGATGAAATTGACTCCATTGGCTCCTCGAGGCTGGAG
GGGGGCTCTGGAGGGGACAGTGAAGTCCAGCGCACTATGCTGGAGCTGCTCAACCAGCTG
GATGGCTTTGAGGCCACCAAGAATATCAAGGTTATCATGGCAACCAATAGGATTGACATC
CTAGACTCGGCGCTGCTCCGCCCAGGGCGCATAGACAGAAAAATTGAATTCCCACCCCCC
AACGAGGAGGCCCGGCTGGACATTTTGAAGATCCATTCTCGGAAAATGAACCTGACCCGG
GGGATCAACCTGAGAAAAATTGCTGAGCTCATGCCAGGAGCGTCAGGGGCTGAAGTGAAG
GGCGTGTGCACCGAGGCTGGCATGTACGCGCTGCGGGAGCGCCGCGTCCACGTCACGCAG
GAGGACTTTGAGATGGCAGTGGCTAAGGTCATGCAAAAGGACAGTGAGAAAAACATGTCC
ATCAAGAAACTATGGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 406 |
| Molecular Weight
| 45626.0 |
| Theoretical pI
| 7.66 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>26S protease regulatory subunit 8
MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLR
EELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDS
YTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGI
AQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMARE
HAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDI
LDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVK
GVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
|
| External Links |
|---|
| GenBank ID Protein
| AAC19266.1 |
| UniProtKB/Swiss-Prot ID
| P62194 |
| UniProtKB/Swiss-Prot Entry Name
| PRS8_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF069053 |
| GeneCard ID
| PSMC5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
