| Identification |
|---|
| BMDB Protein ID
| BMDBP01278 |
| Secondary Accession Numbers
| None |
| Name
| GTP cyclohydrolase 1 feedback regulatory protein |
| Synonyms
|
Not Available
|
| Gene Name
| GCHFR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity). |
| Pathways
|
Not Available
|
| Reactions
|
| Formamidopyrimidine nucleoside triphosphate + Water → 2,5-Diaminopyrimidine nucleoside triphosphate + Formic acid |
details
|
| Guanosine triphosphate + Water → Formamidopyrimidine nucleoside triphosphate + Formic acid |
details
|
| 2,5-Diaminopyrimidine nucleoside triphosphate → 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine |
details
|
| 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine → Dihydroneopterin triphosphate + Water |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| GCHFR |
| Gene Sequence
|
>255 bp
ATGCCCTACCTGCTCATCAGCACCCAGATACGCATGGAGGTGGGCCCCACCGTGGTGGGC
GATGAGCACTCAGATCCAGAACTGATGCAGCATCTGGGGGCCTCAAAAAGAAGTGTCCTG
GGAAACAACTTCTCTGAGTACTACGTGAATGACCCTCCTCGAATCGTCCTGGACAAGCTG
GAGCGCAGGGGCTTCCGTGTGCTGAGCATGACAGGGGTGGGCCAGACGCTGGTGTGGTGC
CTGCACAAGGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 84 |
| Molecular Weight
| 9557.0 |
| Theoretical pI
| 6.79 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>GTP cyclohydrolase 1 feedback regulatory protein
MPYLLISTQIRMEVGPTVVGDEHSDPELMQHLGASKRSVLGNNFSEYYVNDPPRIVLDKL
ERRGFRVLSMTGVGQTLVWCLHKE
|
| External Links |
|---|
| GenBank ID Protein
| AAI09779.1 |
| UniProtKB/Swiss-Prot ID
| Q32L41 |
| UniProtKB/Swiss-Prot Entry Name
| GFRP_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC109778 |
| GeneCard ID
| GCHFR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
