| Identification |
|---|
| BMDB Protein ID
| BMDBP01280 |
| Secondary Accession Numbers
| None |
| Name
| Hormone-sensitive lipase |
| Synonyms
|
Not Available
|
| Gene Name
| LIPE |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. |
| Pathways
|
- Glycerolipid Metabolism
- Triacylglycerol degradation
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| LIPE |
| Gene Sequence
|
>2271 bp
ATGGACCTGCGCACCATGACACAGTCGCTGGTGTCCCTGGCAGAGGACAACATGGCCTTC
TTCTCCAGCCAGGGCCCCGGGGAGACGGCCCGGCGGCTGACGGGCGTCTTTGCGGGCATT
CGGGAGCAGGCCCTGGGGCTGGAGCCGGCCCTGGGCCGCCTGCTGAGCGTGGCGCACCTC
TTTGACCTGGACACAGAGACGCCGGCCAATGGGTACCGCAGCCTGGTGCACACGGCCCGC
TGCTGCCTGGCACACCTGCCGCACAAATCGCGCTACGTGGCCTCCAACCGCCGCAGCATC
TTCTTTCGCACCAGCCACAACCTGGCCGAACTCGAGGCCTACCTGGCCGCCCTCACCCAG
CTCCGCGCTCTGGCTTACTACGCCCAGCGCCTGCTGACCACCAACCAGCCCGGGAGGCTC
TTCTTTGAGGGTGATGAGAGGGTAATTGCCGACTTCCTACGAGAGTACGTCACGCTGCAC
AAAGGCTGCTTCTACGGCCGCTGCCTGGGTTTCCAGTTCACACCTGCCATCCGGCCGTTC
CTGCAGACCATCTCCATCGGACTGGTGTCCTTCGGGGAGCACTACAAACGAAACGAGACT
GGCATCAGTGTGACCGCCAGCTCCCTCTTCACTGACGGCCGCTTTGCCATCGACCCCGAG
CTGCGTGGGGCCGAGTTTGAGCGGATCATTCAGAACCTAGACGTGCACTTCTGGAAAGCT
TTCTGGAATATCACCGAGATCCAGGTGCTATCGTCTCTAGCAAACATGGCCTCAACCACC
GTGAGGGTGAGCCGCCTGCTCAGCCTGCCACCCGTCGCCTTTGAAATGCCTCTGACCTCG
GACCCCGAGCTCACAGTCACCATCTCGCCCCCGCTGGCCCACACAGGCCCTGGGCCTGTC
CTCGTCAGGCTCATCTCCTATGACCTGCGGGAAGGACAGGACAGCAAGGAGCTCAGCAGC
TTCGTGAGGTCCGAGGGCCCCAGGAGCCTGGAGCTGCGGCTGCGCCCCCAGCAGGCACCC
CGCTCCAGGGCCCTGGTGGTGCACATCCACGGCGGCGGCTTCGTGGCCCAGACCTCCAAG
TCGCACGAGCCTTACCTCAAGAGCTGGGCCCAGGAGCTGGGCGCCCCCATCCTCTCCATC
GACTACTCCCTGGCCCCAGAGGCCCCCTTCCCCCGGGCGCTCGAAGAGTGCTTCTATGCC
TACTGCTGGGCCGTCAAGCACTGCGCCCTGCTCGGCTCAACAGGTGAGCGGATATGCCTC
GCTGGAGACAGCGCCGGCGGGAACCTCTGCTTCACCGTGTCCCTTCGGGCAGCGGCCTAC
GGGGTGCGGGTGCCCGATGGCATCATGGCAGCCTACCCGGCCACCATGCTGCAGTCCACC
GCCTCTCCTTCCCGCCTGCTGAGCCTCATGGACCACCTGCTGCCTCTCAGCGTGCTCTCC
AAGTGCGTCAGCACCTATGCCGGTGCGGAGACTGAGGACCACCCCGACTCAGACCAGAAG
GCGCTGGGTGTGATGGGGCTCGTGCAGCGGGACACGGCCCTGCTCTTGCGAGACCTCCGG
CTGGGCGCCTCCTCGTGGCTCAACTCCTTCTTGGAGTTGGGTGGGCAAAAGTCCCACCTG
AAATCAGTGTCCAAGACAGAGCCAATGCGGCGCAGTGTGTCTGAAGCAGCCCTGACCCAG
CCGGAGGGCTCACTGGGAACCGACTCCCTCAAAAGCCTGAAGCTGCATGACCTGGGCCTC
AGGAACAGCAGTGACACAACAGACACGCCAGAGCTGTCACTGTCCGCGGAGACACTCGGC
CCCTCCGCACCCTCAACCATCAACTTCTTACTTGGATCTGAGGATGGATCTGAAATGTCT
AAGGCCCCAGAGGAGCTGAACAACAAGGACCGAGTTCGAGGTGTGGGCGCCGCCTTCCCC
GAGGGTTTCCACCCACGGCGCTGCAGCCAGGGTGCCATGTGGATGCCCCTCTACTCGGCC
CCCATCGTCAAGAATCCCTCCATGTCACCGCTGCTGGCACCCGACAGCATGCTGCAGACT
CTGCCACCTGTGCACATCGTGGCCTGCGCGCTGGATCCCATGCTGGACGACTCGGTCATG
TTCGCGCGGCGGCTCCGCGGCCTGGGCCAGCCCGTGACGCTGCGCGTGGCGGAGGACCTG
CCGCACGGCTTCCTGAGCCTGGCGGCTTTGTGCCGGGAGACGCGGCAGGCAGCCGCGCTG
TGCGTGGAGCGCATCCGTCTCATCCTCAATCTTCCCGGGCCGCCGGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 756 |
| Molecular Weight
| 82641.0 |
| Theoretical pI
| 7.16 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hormone-sensitive lipase
MDLRTMTQSLVTLAEDNMAFFSSQGPGETARRLTGVFAGIREQALGLEPALGRLLSVAHL
FDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQ
LRALAYYAQRLLTTNQPGRLFFEGDERVIADFLREYVTLHKGCFYGRCLGFQFTPAIRPF
LQTISIGLVSFGEHYKRNETGISVTASSLFTDGRFAIDPELRGAEFERIIQNLDVHFWKA
FWNITEIQVLSSLANMASTTVRVSRLLSLPPVAFEMPLTSDPELTVTISPPLAHTGPGPV
LVRLISYDLREGQDSKELSSFVRSEGPRSLELRLRPQQAPRSRALVVHIHGGGFVAQTSK
SHEPYLKSWAQELGAPILSIDYSLAPEAPFPRALEECFYAYCWAVKHCALLGSTGERICL
AGDSAGGNLCFTVSLRAAAYGVRVPDGIMAAYPATMLQSTASPSRLLSLMDHLLPLSVLS
KCVSTYAGAETEDHPDSDQKALGVMGLVQRDTALLLRDLRLGASSWLNSFLELGGQKSHL
KSVSKTEPMRRSVSEAALTQPEGSLGTDSLKSLKLHDLGLRNSSDTTDTPELSLSAETLG
PSAPSTINFLLGSEDGSEMSKAPEELNNKDRVRGVGAAFPEGFHPRRCSQGAMWMPLYSA
PIVKNPSMSPLLAPDSMLQTLPPVHIVACALDPMLDDSVMFARRLRGLGQPVTLRVAEDL
PHGFLSLAALCRETRQAAALCVERIRLILNLPGPPV
|
| External Links |
|---|
| GenBank ID Protein
| ABL84202.1 |
| UniProtKB/Swiss-Prot ID
| P16386 |
| UniProtKB/Swiss-Prot Entry Name
| LIPS_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| EF140760 |
| GeneCard ID
| LIPE |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
