| Identification |
|---|
| BMDB Protein ID
| BMDBP01281 |
| Secondary Accession Numbers
| None |
| Name
| Lysophosphatidylserine lipase ABHD12 |
| Synonyms
|
Not Available
|
| Gene Name
| ABHD12 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acylglycerol lipase activity |
| Specific Function
| Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| ABHD12 |
| Gene Sequence
|
>1197 bp
ATGAGGAAGCGGACCGAGCCCGTCGCCCTGGAGCATGAACGCCGTACCGCCTCGGGCTCG
CCCTCCGCCGGCCCGGCCGCCGCGGCGCTGGACGCCGACTGCCGCCTGAAGCAGAACCTG
TGCCTAGCGGGCCCTGGGCCGGCCGAGCCGCGCTGCGCCGCGGACGCGGGCATGAAGCGG
GCGCTGGGCAGGCGAAAGGGCCTGTGCTTCCGACTGAGGAAGATACTCTTCTTTGTCCTG
GGATTGTATGTGGCCATTCCATTTCTCATCAAACTATGTCCTGGGATACAGGCCAAACTG
ATTTTCTTGAATTTCGTGCGGGTTCCCTATTTCATTGATTTGAAAAGACCACAGGATCAA
GGTTTGAATCACACCTGTAATTACTACCTCCAGCCAGAGGAAGACGTAACCATTGGAGTC
TGGCACACGGTCCCCACTGTCTGGTGGAAGAATGCCCAGGGGAAGGACCAGATGTGGTAC
GAGGATGCCCTGTCTTCCAGCCACCCGATCATCCTGTACCTGCATGGGAACGCGGGCACC
AGAGGCGGCGACCACCGGGTGGAGCTTTACAAGGTGCTGAGTTCCCTCGGCTACCACGTG
GTCACCTTTGACTACAGAGGTTGGGGTGACTCAGTAGGAACGCCGTCGGAGCGGGGCATG
ACGTATGATGCACTCCATGTTTTTGACTGGATCAAAGTGCGAAGTGGAGACAACCCTGTG
TATATTTGGGGCCATTCTCTTGGCACCGGAGTGGCCACAAACCTGGTGCGGCGCCTCTGT
GAGCGAGAGACTCCTCCAGATGCCCTCATCTTGGAATCTCCATTCACTAATATCCGTGAA
GAAGCCAAGAGCCATCCGTTCTCAGTGATCTATCGATATTTCCCTGGGTTTGACTGGTTC
TTCCTTGATCCCATCACAAGCAGTGGAATTCAGTTTGCAAATGATGAAAATGTGAAGCAC
ATCTCCTGCTCCCTGCTCATCCTGCATGCCGAGGACGACCCGGTCGTGCCCTTCCAGCTC
GGCAGAAAGCTCTACAACATCGCCGCACCGTCACGCAGCTTCCGGGACTTTAAGGTTCAG
TTCATCCCCTTCCACTCGGACCTTGGCTACAGGCACAAGTACATCTACAAGAGCCCCGAG
CTCCCGCGGATCCTGAGGGAGTTCCTGGGGAAGTCGGAACCGGGACGCCAGCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 398 |
| Molecular Weight
| 45220.0 |
| Theoretical pI
| 8.96 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Monoacylglycerol lipase ABHD12
MRKRTEPVALEHERRTASGSPSAGPAAAALDADCRLKQNLCLAGPGPAEPRCAADAGMKR
ALGRRKGLCFRLRKILFFVLGLYVAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKRPQDQ
GLNHTCNYYLQPEEDVTIGVWHTVPTVWWKNAQGKDQMWYEDALSSSHPIILYLHGNAGT
RGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKVRSGDNPV
YIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWF
FLDPITSSGIQFANDENVKHISCSLLILHAEDDPVVPFQLGRKLYNIAAPSRSFRDFKVQ
FIPFHSDLGYRHKYIYKSPELPRILREFLGKSEPGRQH
|
| External Links |
|---|
| GenBank ID Protein
| AAI23535.1 |
| UniProtKB/Swiss-Prot ID
| Q08DW9 |
| UniProtKB/Swiss-Prot Entry Name
| ABD12_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC123534 |
| GeneCard ID
| ABHD12 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
