Showing Protein Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (BMDBP01296)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01296 |
| Secondary Accession Numbers | None |
| Name | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
| Synonyms | Not Available |
| Gene Name | GCNT1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in beta-1,3-galactosyl-O-glycosyl-glycoprotein |
| Specific Function | Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 8 |
| Locus | Not Available |
| SNPs | GCNT1 |
| Gene Sequence |
>1284 bp ATGCTGAGGAAGTTGTGGAGGAGGAAACTTTTTTCTTTTCCCACTAAATACTACTTCTTA TTTCTTGCTTTTTCGGTGGTCACATTCACTGTTTTAAGAATTCATCAAAAGACTGAATTT GTAAATTTTGGACATTTGGAGCTGTTTGAAGAGAATCCTAGTAGTAATATTAATTGCACC AAAATTCTACAGGGTGATGTAGATGAAATCCAAAAGGTAAAGCTTGAGAGTCTAACAGTG AAATTTAAAAAGCGCGCTCGATGGACAAACTATGACTACATAAACATGACTGGTGATTGT GCTTCTTTCATTAAGAAGCGCAAATATATTACAGAACCACTTAGTAAAGAAGAGGCGGGA TTTCCAATAGCATATTCTATAGTGGTTCATCACAAAATTGAAATGCTTGACAGGCTCCTG AGGGCCATCTATATGCCTCAGAATTTCTATTGTATTCACGTGGATGCAAAATCAGAGAAA TCCTTTTTGGCTGCAGCTGTTGGCATCGCATCCTGCTTCAGTAATGTCTTTGTCGCCAGT CAGCTGGAGAGCGTGGTGTATGCGTCCTGGAGCCGGGTTCAGGCTGACCTTAACTGCATG CAGGACCTCTACCAGATGAATGCAGGCTGGAAGTACCTGATAAACCTCTGCGGTATGGAT TTTCCTATTAAAACCAACCTGGAAATTGTCAGGAAGCTCAAGCTATTGATGGGCGAGAAC AACCTAGAAACAGAGAAAATGCCATCCCATAAGAAAGAAAGGTGGAAAAAGCATTATGAA GTCGTGAATGGAAAGCTGACAAACATGGGGACTGACAAAATACATCCACCTCTTGAAACA CCTCTGTTTTCAGGCAGTGCTCATTTTGTGGTCAGTAGGGAATATGTGGAGTACGTGCTC CAGAACCAAAATATACAAAAGTTTATGGAGTGGGCAAAAGACACATACAGCCCAGACGAG TATCTCTGGGCCACTATTCAGAGGATCCCCGAAGTCCCAGGGTCATTGTCCTTAAGCTAT AAGTATGACACGTCCGACATGCAAGCGATTGCCAGGTTTGTTAAATGGCAGTACTTTGAA GGAGACGTTTCCAAGGGCGCCCCCTACCCGCCGTGCAGCGTCCACGTTCGCTCTGTGTGC GTTTTCGGAGCTGGTGACTTGAACTGGCTGTTGCACGTGCACCACTTGTTTGCCAACAAA TTCGACACGGACATTGACCTCTTTGCCATCCAGTGTTTGGACGAGCATCTAAGGCATAAA GCCCTGGAGACGTTAAAACCCTGA |
| Protein Properties | |
| Number of Residues | 427 |
| Molecular Weight | 49734.0 |
| Theoretical pI | 8.57 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase MLRKLWRRKLFSFPTKYYFLFLAFSVVTFTVLRIHQKTEFVNFGHLELFEENPSSNINCT KILQGDVDEIQKVKLESLTVKFKKRARWTNYDYINMTGDCASFIKKRKYITEPLSKEEAG FPIAYSIVVHHKIEMLDRLLRAIYMPQNFYCIHVDAKSEKSFLAAAVGIASCFSNVFVAS QLESVVYASWSRVQADLNCMQDLYQMNAGWKYLINLCGMDFPIKTNLEIVRKLKLLMGEN NLETEKMPSHKKERWKKHYEVVNGKLTNMGTDKIHPPLETPLFSGSAHFVVSREYVEYVL QNQNIQKFMEWAKDTYSPDEYLWATIQRIPEVPGSLSLSYKYDTSDMQAIARFVKWQYFE GDVSKGAPYPPCSVHVRSVCVFGAGDLNWLLHVHHLFANKFDTDIDLFAIQCLDEHLRHK ALETLKP |
| External Links | |
| GenBank ID Protein | AAA83244.1 |
| UniProtKB/Swiss-Prot ID | Q92180 |
| UniProtKB/Swiss-Prot Entry Name | GCNT1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | U41320 |
| GeneCard ID | GCNT1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |