Showing Protein Beta-1,4-glucuronyltransferase 1 (BMDBP01298)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01298 |
| Secondary Accession Numbers | None |
| Name | Beta-1,4-glucuronyltransferase 1 |
| Synonyms | Not Available |
| Gene Name | B4GAT1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in N-acetyllactosaminide beta-1,3-N-acetylgluc |
| Specific Function | Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1). |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 29 |
| Locus | Not Available |
| SNPs | B4GAT1 |
| Gene Sequence |
>1248 bp ATGCAGATGTCCTACGCCATCCGATGTGCCTTCTACCAGCTGCTGCTGGCCGCGCTCATG CTGGTGGCTATGCTGCAGCTGCTCTACCTGTCGCTGCTGTCCGGGCTGCATGGGCAAGAA GAGCAAGACCAATATTTCGAGTTCTTTCCCCCATCCCCGCGGTCGGTGGACCAAGTCAAG GCGCAGCTCCGCACCGCGCTGGCCTCCGGAGGCGTCCTGGACGCCAGCGGCGACTACCGC GTCTACAGGGGCCTACTGAAGACCACCATGGACCCCAACGATGTGATCCTGGCCACTCAC GCCAGTGTGGACAACCTGCTGCACCTGTCGGGCCTGTTGGAGCGCTGGGAGGGCCCTCTG TCGGTGTCGGTGTTCGCCGCCACCAAGGAGGAGGCGCAGCTGGCCACGGTGCTGACCTAC GCGCTGAGCAGCCACTGCCCCGATATGCGTGCCAGGGTCGCCATGCACCTTGTGTGCCCC TCACGCTACGAGGCCGCCGTTCCCGACCCCCGGGAGCCAGGGGAGTTTGCCCCGTTGCGT TCCTGCCAGGAGGTCTTTGACAAGCTGGCTAGGGTGGCCCAGCCCGGGGTCAATTACGCG CTGGGCACCAACGTCTCCTACCCCAATAACCTGCTGAGGAATCTGGCTCGTGAGGGGGCC AACTATGCCCTGGTAATCGACGTGGACATGGTGCCCAGCGAGGGGCTGTGGAGAAGCCTG CGGGAAATGCTGGATCAGAGCAAGCAGTGGGCGGGCACAGCGCTGGTGGTGCCTGCCTTT GAGATCCGTCGAGCTCGCCGCATGCCCATGAACAAAAACGAGCTGCTGCAGCTCTACCAG GTGGGCGAGGTGCGGCCCTTCTATTATGGGCTCTGCACCCCCTGCCAGGCGCCCACCAAC TACTCCCGCTGGGTCAACCTGCCAGAAGAGACCTTGCTGAGGCCTGCCTACGTGGTGCCC TGGCAAGACCCCTGGGAGCCATTCTACGTGGCTGGAGGCAAGGTGCCCACCTTCGACGAG CGCTTTCGGCAGTATGGCTTCAATCGTATCAGCCAGGCCTGTGAGCTGCACGTGGCAGGA TTCGATTTCGAGGTGCTGAATGAAGGTTTCCTGGTTCATAAAGGCTTCAAAGAAGTTTTG AAATTCCATCCCCAAAAGGAGGCTGAAAATCAGCACAATAAGATCCTTTACCGTCAGTTC AAACAGGAGTTGAAGGCCAAGTACCCTGACTCCCCGCGTCACTGCTGA |
| Protein Properties | |
| Number of Residues | 415 |
| Molecular Weight | 47231.0 |
| Theoretical pI | 7.03 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase MQMSYAIRCAFYQLLLAALMLVAMLQLLYLSLLSGLHGQEEQDQYFEFFPPSPRSVDQVK AQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHASVDNLLHLSGLLERWEGPL SVSVFAATKEEAQLATVLTYALSSHCPDMRARVAMHLVCPSRYEAAVPDPREPGEFALLR SCQEVFDKLARVAQPGVNYALGTNVSYPNNLLRNLAREGANYALVIDVDMVPSEGLWRSL REMLDQSKQWAGTALVVPAFEIRRARRMPMNKNELLQLYQVGEVRPFYYGLCTPCQAPTN YSRWVNLPEETLLRPAYVVPWQDPWEPFYVAGGKVPTFDERFRQYGFNRISQACELHVAG FDFEVLNEGFLVHKGFKEVLKFHPQKEAENQHNKILYRQFKQELKAKYPDSPRHC |
| External Links | |
| GenBank ID Protein | AAX08785.1 |
| UniProtKB/Swiss-Prot ID | Q5EA01 |
| UniProtKB/Swiss-Prot Entry Name | B4GA1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BT020768 |
| GeneCard ID | B4GAT1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |