Showing Protein Guanylyl cyclase-activating protein 1 (BMDBP01299)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01299 |
| Secondary Accession Numbers | None |
| Name | Guanylyl cyclase-activating protein 1 |
| Synonyms | Not Available |
| Gene Name | GUCA1A |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in calcium ion binding |
| Specific Function | Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:7520254, PubMed:8626484, PubMed:9651312, PubMed:26703466). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (PubMed:7520254, PubMed:8626484). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 23 |
| Locus | Not Available |
| SNPs | GUCA1A |
| Gene Sequence |
>618 bp ATGGGGAACATTATGGACGGTAAGTCGGTGGAGGAGCTGAGCAGCACCGAGTGCCACCAG TGGTACAAGAAGTTCATGACAGAGTGCCCCTCCGGCCAGCTCACCCTCTACGAGTTCCGC CAGTTCTTCGGCCTCAAGAACCTGAGCCCGTGGGCCAGCCAGTACGTGGAGCAGATGTTT GAGACCTTTGACTTCAACAAAGACGGCTACATTGATTTCATGGAGTACGTGGCGGCTCTG AGCCTGGTCCTCAAGGGGAAGGTGGAACAGAAGCTGCGTTGGTACTTCAAGCTCTACGAC GTGGACGGCAACGGATGCATCGACCGCGACGAGCTGCTCACCATCATCCGGGCCATCCGA GCCATTAACCCCTGCAGCGACTCGACCATGACCGCCGAGGAGTTCACCGATACAGTGTTC TCCAAGATTGACGTCAATGGGGATGGGGAACTCTCCCTAGAGGAGTTCATGGAGGGCGTC CAGAAGGACCAGATGCTCTTGGACACGCTGACCCGAAGCTTGGACCTTACCCGCATTGTG CGCAGGCTCCAGAATGGAGAGCAGGATGAGGAGGGGGCTAGCGGCAGGGAAACGGAGGCC GCGGAGGCCGACGGCTGA |
| Protein Properties | |
| Number of Residues | 205 |
| Molecular Weight | 23510.0 |
| Theoretical pI | 4.14 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Guanylyl cyclase-activating protein 1 MGNIMDGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSPWASQYVEQMF ETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIRAIR AINPCSDSTMTAEEFTDTVFSKIDVNGDGELSLEEFMEGVQKDQMLLDTLTRSLDLTRIV RRLQNGEQDEEGASGRETEAAEADG |
| External Links | |
| GenBank ID Protein | AAB31698.2 |
| UniProtKB/Swiss-Prot ID | P46065 |
| UniProtKB/Swiss-Prot Entry Name | GUC1A_BOVIN |
| PDB IDs | |
| GenBank Gene ID | S74247 |
| GeneCard ID | GUCA1A |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |