| Identification |
|---|
| BMDB Protein ID
| BMDBP01303 |
| Secondary Accession Numbers
| None |
| Name
| Complement C1s subcomponent |
| Synonyms
|
Not Available
|
| Gene Name
| C1S |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). |
| Pathways
|
- Classical Complement Pathway
- Complement Pathway
- Lectin-Induced Complement Pathway
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| C1S |
| Gene Sequence
|
>2088 bp
ATGAACAAATTGCCAGAGATGTGGTGCATTGTCCTGTTTTCCCTTGTGGCCTGGGTTTAT
GCCGAGCCTACTATGTATGGAGAGATTCTATCCCCCAACTACCCTCAGGTGTACCCCAAC
GAGGTCGAGAAGTCTTGGGACATAGAAGTCCCTGCAGGGTACGGGATCCACCTTTACTTC
ACCCACCTGGATATAGAGTTGTCTGAGAACTGCTCCTATGATTCAGTGCAGATAATGTCG
GGAGGCCATGAAGAAGGGAAACTCTGTGGACGGAGGACCAACAAGAATTCAAACTCCCCA
GTGGTGAAAGAGTTCCACATCCCATACAGTAAATTGCAGGTGATCTTCCGGTCGGACTTC
TCCAACGAGGAGCGTTTCACCGGGTTTGCTGCGTACTATGTTGCTGAGGATATAGATGAG
TGCACAGCCTTTGCAGATGCTCCTTGCAGCCACTTCTGCAATAACTTCCTTGGTGGTTAC
TTCTGCTCCTGCCCTCCAGAATACTTCCTCCATGAAGACAAGAAGAACTGTGGAGTCAAT
TGCAGTGGAAATGTATTCACCACAATGACTGGGGAGGTTGAAAGTCCTAATTACCCCAGT
CCATACCCAGAGAGCTCAAGGTGTGACTATCAGATCCAGTTGGAGGAGGGGTTCCGAGTG
GTGGTGACCATGAGGAGAGAAGACTTTGATGTGGAACCAGCTGACTCCGAGGGCCACTGT
CCCGACAGTTTGCTCTTTGTGGCAGGAGACCAGCATTTTGGTCCTTACTGTGGGAACGGC
TTTCCTGGGCCACTAACAATTGAAACCCAGAGCAGTGCTCTGAATATCATCTTCCAAACT
GATGGATCAGAACAAAGAAAGGGATGGAAATTTCGTTACCATGGAGATCCAATCCCTTGT
CCTAAAGAAGTCACTGCCAATTCCTTCTGGGAGCCTGAGAGAGCAAAATATGTGTTCAGA
GATGTGGTGAAGATAACCTGTGTGGATGGGTTTGAAGTTGTGCAGGGAAGTGTTGGTTCC
CCATCTTTCTACTCTACTTGTCAAAGCAATGGAAAGTGGAGTAATTCCAAGTTGCGGTGT
CAACCCGTGGACTGTGGCGCTCCTGAACCCATTCAGCATGGTAGAGTCGAAGATCCAGAA
AGTACTCTATTTGGTTCCATCACTCGCTACTCTTGTGAGATGCCATATTACAGCATGGAA
TGTGAAGGGAGCGAGGTGTATCACTGCAGTGGCAATGGGAGCTGGGTGAACAAGGTGCTG
GGCATAGAGCCGCCGAAATGCATTGCAGTCTGTGGCACCCCCAGCGAGCCTTTTAGATCA
ACACAAAGAATATTTGGAGGCTCCATTGCGAAGATTGAAAATTTCCCCTGGCAAGTCTTC
TTCTCGAACCCATGGGCTGGTGGGGCTCTCATTGATGAATACTGGGTGCTGACAGCTGCC
CATGTCGTGGAGGGAAACGATATCCCAGTGATGTATGTTGGGTCCTCCTCAGTGGTCACC
TCACAATTGTCAAATGCTCAGATGCTCACTGCAGAGAGAGTGTTTATCCATCCAGGATGG
GAGGTCCTGGATCCTTCGATAACACGAAAGAATTTTGACAATGACATTGCGCTGGTGCGG
CTGAGAGACCCAGTGAAAATGGGACCCAAGGTCGCCCCTATCTGCCTACCAGGCACCTCC
TCAGAATATGACCCTCCGGAGAACGTCCTGGGCCTGATCTCAGGTTGGGGTCGAACAAAT
GTCAAAAGTCATGTTATTAAGCTCAGAGGGGCAAAGCTACCCGTTGCTCCCTTATCCAAA
TGCCGGGAGATGAAGGGGGTCAATCCTGGAATAGATATCAGTTCTTTTGTTTTCACTGAG
AACATGATCTGTGCCGGTAATGACAAGGGTGTTGACAGCTGTGACGGGGACAGTGGTGGG
GCCTTTGCTGTACAGGACCCTAAGGAAAACAAGCCCAAATTCTATGTTGCTGGTTTGGTG
TCCTGGGGCCCCCAGTGTGGGACCTATGGGATCTACACGCGAGTCAAGAACTACGTTGAC
TGGATAAGGAAGACAATGCAGGAGTATAGTGCCCCCAGTGTAGACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 689 |
| Molecular Weight
| 76609.0 |
| Theoretical pI
| 4.72 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Complement C1s subcomponent
MWCIVLFSLVAWVYAEPTMYGEILSPNYPQVYPNEVEKSWDIEVPAGYGIHLYFTHLDIE
LSENCSYDSVQIMSGGHEEGKLCGRRTNKNSNSPVVKEFHIPYSKLQVIFRSDFSNEERF
TGFAAYYVAEDIDECTAFADAPCSHFCNNFLGGYFCSCPPEYFLHEDKKNCGVNCSGNVF
TTMTGEVESPNYPSPYPESSRCDYQIQLEEGFRVVVTMRREDFDVEPADSEGHCPDSLLF
VAGDQHFGPYCGNGFPGPLTIETQSSALNIIFQTDGSEQRKGWKFRYHGDPIPCPKEVTA
NSFWEPERAKYVFRDVVKITCVDGFEVVQGSVGSPSFYSTCQSNGKWSNSKLRCQPVDCG
APEPIQHGRVEDPESTLFGSITRYSCEMPYYSMECEGSEVYHCSGNGSWVNKVLGIEPPK
CIAVCGTPSEPFRSTQRIFGGSIAKIENFPWQVFFSNPWAGGALIDEYWVLTAAHVVEGN
DIPVMYVGSSSVVTSQLSNAQMLTAERVFIHPGWEVLDPSITRKNFDNDIALVRLRDPVK
MGPKVAPICLPGTSSEYDPPENVLGLISGWGRTNVKSHVIKLRGAKLPVAPLSKCREMKG
VNPGIDISSFVFTENMICAGNDKGVDSCDGDSGGAFAVQDPKENKPKFYVAGLVSWGPQC
GTYGIYTRVKNYVDWIRKTMQEYSAPSVD
|
| External Links |
|---|
| GenBank ID Protein
| AAI19957.1 |
| UniProtKB/Swiss-Prot ID
| Q0VCX1 |
| UniProtKB/Swiss-Prot Entry Name
| C1S_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC119956 |
| GeneCard ID
| C1S |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
