| Identification |
|---|
| BMDB Protein ID
| BMDBP01305 |
| Secondary Accession Numbers
| None |
| Name
| Deoxyribonuclease-1 |
| Synonyms
|
Not Available
|
| Gene Name
| DNASE1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in actin binding |
| Specific Function
| Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:4976790, PubMed:5166750, PubMed:3352748, PubMed:2395459). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:2395459). Binds specifically to G-actin and blocks actin polymerization (PubMed:2395459). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| DNASE1 |
| Gene Sequence
|
>849 bp
ATGAGGGGCACCAGGCTGATGGGGCTGCTGCTCGCCCTCGCTGGTCTGCTGCAGCTGGGC
TTGTCCCTGAAGATAGCAGCCTTCAACATCCGCACCTTTGGGGAGACCAAGATGTCCAAT
GCTACGCTCGCCAGCTACATTGTTCGGATCGTGCGTCGTTACGACATCGTCCTCATCCAG
GAGGTCAGAGACAGCCACCTGGTGGCTGTGGGGAAGCTCCTGGACTATCTCAACCAGGAT
GACCCAAACACCTACCACTATGTGGTCAGTGAGCCGCTGGGCCGCAACAGCTACAAGGAG
CGCTACCTCTTTCTGTTCAGACCCAACAAGGTGTCCGTGCTGGACACCTACCAGTACGAC
GACGGCTGCGAGTCCTGCGGGAACGACAGCTTCAGCCGGGAGCCCGCTGTGGTCAAGTTC
TCATCCCACTCCACCAAGGTCAAGGAATTTGCCATTGTTGCCCTGCACTCGGCCCCATCG
GACGCAGTGGCTGAGATTAATTCTCTCTACGATGTCTACCTGGATGTCCAGCAGAAGTGG
CACTTGAACGATGTCATGTTGATGGGCGATTTCAATGCTGACTGCAGCTACGTGACCTCC
TCGCAGTGGTCATCCATCCGCCTGCGTACGAGCTCCACCTTCCAGTGGCTGATTCCTGAC
AGTGCCGACACCACGGCTACGTCCACGAACTGCGCCTATGACAGGATCGTGGTCGCAGGG
TCTCTGCTCCAGAGTTCTGTGGTTCCTGGCTCGGCCGCTCCCTTTGACTTCCAAGCTGCA
TACGGACTGAGCAATGAGATGGCCCTGGCCATCAGTGACCATTACCCGGTGGAGGTGACG
CTGACATAA
|
| Protein Properties |
|---|
| Number of Residues
| 282 |
| Molecular Weight
| 31346.0 |
| Theoretical pI
| 5.31 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Deoxyribonuclease-1
MRGTRLMGLLLALAGLLQLGLSLKIAAFNIRTFGETKMSNATLASYIVRIVRRYDIVLIQ
EVRDSHLVAVGKLLDYLNQDDPNTYHYVVSEPLGRNSYKERYLFLFRPNKVSVLDTYQYD
DGCESCGNDSFSREPAVVKFSSHSTKVKEFAIVALHSAPSDAVAEINSLYDVYLDVQQKW
HLNDVMLMGDFNADCSYVTSSQWSSIRLRTSSTFQWLIPDSADTTATSTNCAYDRIVVAG
SLLQSSVVPGSAAPFDFQAAYGLSNEMALAISDHYPVEVTLT
|
| External Links |
|---|
| GenBank ID Protein
| CAA04819.1 |
| UniProtKB/Swiss-Prot ID
| P00639 |
| UniProtKB/Swiss-Prot Entry Name
| DNAS1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| AJ001538 |
| GeneCard ID
| DNASE1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
