| Identification |
|---|
| BMDB Protein ID
| BMDBP01306 |
| Secondary Accession Numbers
| |
| Name
| Coagulation factor VII |
| Synonyms
|
Not Available
|
| Gene Name
| F7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| Not Available |
| SNPs
| F7 |
| Gene Sequence
|
>1344 bp
ATGCTGTCCCAGGCCTGGGCTCTGGCCCTCCTCTGCTTTCTGCTCAGCCTGTGGGGGTCC
CTGCCGGCAGTCTTCCTGCCCCAGGAGCAGGCCCTCAGCATCCTGCATCGGCCTCGGCGT
GCCAACGGGTTCCTGGAGGAGCTGCTGCCGGGCTCGCTGGAGCGGGAGTGCAGGGAGGAG
CTCTGCTCCTTCGAGGAAGCCCACGAGATCTTCCGCAACGAGGAGAGGACGAGGCAGTTC
TGGGTTTCCTACAATGACGGGGACCAGTGCGCCTCCAGCCCCTGCCAGAACGGGGGCTCC
TGTGAGGACCAGCTCCGGTCCTACATCTGCTTCTGCCCCGACGGCTTCGAGGGCCGGAAC
TGTGAGACCGACAAGCAGAGCCAGCTGATCTGCGCCAACGACAATGGCGGCTGTGAGCAG
TACTGTGGGGCTGACCCGGGGGCCGGGCGCTTCTGCTGGTGCCATGAGGGCTACGCGCTC
CAGGCAGACGGGGTGTCCTGCGCACCCACAGTGGAATATCCGTGCGGGAAAATACCTGTT
CTGGAAAAAAGAAATGGCAGCAAGCCCCAAGGGCGAATTGTGGGGGGCCACGTCTGCCCC
AAAGGGGAATGCCCCTGGCAGGCCATGCTGAAGCTGAACGGGGCGCTGCTGTGCGGGGGC
ACCCTGGTCGGCCCGGCCTGGGTGGTCTCCGCCGCCCACTGCTTCGAAAGGCTCCGGAGC
AGGGGGAACCTGACGGCTGTGCTGGGCGAGCACGACCTCAGCCGCGTGGAGGGCCCAGAG
CAGGAGCGGCGGGTGGCGCAGATCATTGTCCCCAAGCAGTACGTGCCGGGCCAGACGGAC
CACGACGTGGCCCTGCTGCAGCTGGCCCAGCCCGTGGCCCTGGGCGACCACGTGGCACCC
CTCTGTCTGCCCGACCCGGACTTCGCGGACCAGACGCTGGCCTTCGTGCGCTTCTCGGCC
GTCAGCGGCTGGGGCCAGCTCCTGGAGCGCGGGGTCACCGCCCGCAAGCTCATGGTGGTG
CTGGTGCCCCGGCTGCTAACCCAGGACTGCCTGCAGCAGTCGCGCCAGAGGCCCGGCGGG
CCTGTGGTCACGGACAACATGTTCTGCGCTGGCTATAGCGACGGCAGCAAGGATGCCTGC
AAGGGGGACAGTGGGGGCCCGCACGCCACACGCTTCCGGGGCACCTGGTTCCTGACCGGC
GTCGTCAGCTGGGGCGAGGGCTGCGCGGCAGCCGGCCACTTTGGGATCTACACGCGGGTC
TCCCGCTACACGGCCTGGCTGCGGCAGCTGATGGGCCACCCGCCGTCCAGGCAGGGCTTC
TTCCAGGTCCCGCTGCTGCCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 447 |
| Molecular Weight
| 48961.0 |
| Theoretical pI
| 6.42 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Coagulation factor VII
MLSQAWALALLCFLLSLWGSLPAVFLPQEQALSILHRPRRANGFLEELLPGSLERECREE
LCSFEEAHEIFRNEERTRQFWVSYNDGDQCASSPCQNGGSCEDQLRSYICFCPDGFEGRN
CETDKQSQLICANDNGGCEQYCGADPGAGRFCWCHEGYALQADGVSCAPTVEYPCGKIPV
LEKRNGSKPQGRIVGGHVCPKGECPWQAMLKLNGALLCGGTLVGPAWVVSAAHCFERLRS
RGNLTAVLGEHDLSRVEGPEQERRVAQIIVPKQYVPGQTDHDVALLQLAQPVALGDHVAP
LCLPDPDFADQTLAFVRFSAVSGWGQLLERGVTARKLMVVLVPRLLTQDCLQQSRQRPGG
PVVTDNMFCAGYSDGSKDACKGDSGGPHATRFRGTWFLTGVVSWGEGCAAAGHFGIYTRV
SRYTAWLRQLMGHPPSRQGFFQVPLLP
|
| External Links |
|---|
| GenBank ID Protein
| AAX46431.1 |
| UniProtKB/Swiss-Prot ID
| P22457 |
| UniProtKB/Swiss-Prot Entry Name
| FA7_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021584 |
| GeneCard ID
| F7 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
