Showing Protein Furin (BMDBP01309)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01309 |
| Secondary Accession Numbers | None |
| Name | Furin |
| Synonyms | Not Available |
| Gene Name | FURIN |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Posttranslational modification, protein turnover, chaperones |
| Specific Function | Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:7806563). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 21 |
| Locus | Not Available |
| SNPs | FURIN |
| Gene Sequence |
>2394 bp ATGGAGCTGAGGCCCTGGTTGTTCTGGGTGGTAGCAGCAGCGGGAGCCTTGGTCCTGCTG GTGGCCGATGCCCGCGGAGAGAAGGTCTTCACCAACACCTGGGCCGTGCACATTCCTGGA GGCCCAGCCGTCGCTGACCGTGTGGCACGCAAGCATGGCTTCCTCAACCTGGGCCAGATC TTCGGTGACTATTACCACTTCTGGCATCGAGCGGTGACAAAGCGGTCCCTGTCTCCTCAC CGCCTGGGCCACAACCGGCTGCAGCGGGAACCTCAAGTTAAGTGGCTGGAGCAGCAGGTG GCAAAGCGACGGGCCAAACGGGACATATACCAGGAGCCCACGGACCCCAAGTTTCCCCAG CAGTGGTACCTGTCTGGCGTCACCCAGCGGGACCTGAATGTGAAGGAGGCCTGGGCGCAG GGCTACACGGGGCGTGGCATTGTGGTCTCTATCCTGGACGACGGCATCGAGAAGAACCAC CCAGACTTGGCAGGCAATTATGATCCTGGGGCCAGCTTCGATGTCAATGATCAGGACCCT GACCCCCAGCCCCGGTACACACAGATGAATGACAACAGGCATGGCACACGGTGTGCAGGA GAGGTGGCTGCGGTGGCCAACAATGGTGTCTGTGGCGTAGGCGTGGCCTACAATGCCCGA ATTGGAGGGGTGCGCATGCTGGATGGCGAAGTGACAGATGCCGTGGAGGCACGCTCGCTG GGCCTGAACCCCAACCACATCCACATCTACAGTGCCAGCTGGGGCCCCGAGGACGACGGC AAGACCGTGGATGGGCCAGCCCACCTGGCTGAGGAGGCCTTCTTCCGGGGGGTCAGCCAG GGCCGCGGGGGTCTGGGCTCCATCTTTGTCTGGGCCTCGGGGAACGGGGGCCGGGAACAT GACAGCTGCAATTGCGACGGCTACACCAACAGCATCTACACGCTGTCCATCAGCAGCGCC ACACAGTTCGGCAACGTGCCCTGGTACAGTGAGGCCTGCTCGTCCACGCTGGCCACCACC TACAGTAGTGGCAACCAGAATGAGAAGCAGATCGTGACCACTGACCTGCGGCAGAAGTGT ACAGAGTCTCACACGGGCACCTCTGCGTTCGCCCCACTGGCAGCAGGCATCATCGCTCTC ACCCTGGAGGCCAATAAGAACCTCACTTGGCGGGACATGCAGCACTTGGTAGTCCGGACC TCAAAGCCAGCCCACCTCAACGCCAACGACTGGGCCACCAATGGTGTGGGCCGCAAAGTG AGCCATTCGTACGGCTACGGGCTGTTGGACGCCGGCGCCATGGTGGCTCTGGCCCAGAAC TGGACGACGGTGGCCCCTCAGCGGAAATGCACCATCGACATCCTCACTGAGCCCAAGGAC ATCGGGAAGCGGCTGGAGGTGCGGAAGACCGTGACCGCCTGCCTGGGGGAGCCCAGCCAC ATCACGCGGCTGGAGCATGCTCAGGCACGGCTCACCCTGTCCTACAACCGCCGCGGTGAC CTTGCCATCCACCTGGTCAGCCCCATGGGCACCCGCTCCACCCTGCTGGCTGCCAGGCCA CATGACTACTCTGCAGATGGGTTTAACGACTGGGCCTTCATGACGACCCATTCCTGGGAC GAGGATCCCTCTGGCGAGTGGGTCTTAGAGATTGAAAACACCAGTGAAGCCAACAACTAT GGGACACTGACCAAGTTCACCCTCGTGCTTTATGGCACGGCCCCTGAGGGTTTGCCCACA CCCCCTGAGAGCATCGGCTGTAAGACCCTCACTTCCAGTCAGGCCTGTGTGGTGTGCGAG GAAGGCTTCTCCTTGCACCAGAAGAACTGCGTCCAGCACTGTCCCCCAGGCTTCGCTCCC CAAGTCCTGGACACACACTACAGCACAGAGAACGACGTGGAGATCATCCGGGCCAGCGTC TGCACGCCCTGCCACGCCTCGTGCGCCACGTGCCAGGGCCCCGCCCCCACAGACTGCCTC AGCTGCCCCAGCCACGCCTCCCTGGACCCGGTGGAGCAGACGTGCTCGCGCCAGAGCCAG AGCAGCCGCGAGTCGCACCAGCAGCAGCCGCCGCCGCCCCCTCGGCCACCGCCCGCGGAG GTAGCGACGGAGCCGCGGCTGCGGGCGGACCTGCTGCCCTCGCACCTGCCCGAGGTGGTG GCCGGCCTCAGCTGCGCCTTCATCGTGCTGGTCTTCGTTACCGTCTTCCTGGTCCTGCAG CTGCGCTCGGGCTTCAGCTTCCGAGGGGTGAAAGTGTACACCATGGACCGCGGCCTCATC TCCTACAAGGGACTACCCCCTGAAGCCTGGCAGGAGGAGTGCCCGTCCGACTCAGAGGAG GACGAGGGCCGGGGCGAGAGGACCGCCTTTATCAAAGACCAGAGCGCCCTTTGA |
| Protein Properties | |
| Number of Residues | 797 |
| Molecular Weight | 87251.0 |
| Theoretical pI | 6.39 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Furin MELRPWLFWVVAAAGALVLLVADARGEKVFTNTWAVHIPGGPAVADRVARKHGFLNLGQI FGDYYHFWHRAVTKRSLSPHRLGHNRLQREPQVKWLEQQVAKRRAKRDIYQEPTDPKFPQ QWYLSGVTQRDLNVKEAWAQGYTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL GLNPNHIHIYSASWGPEDDGKTVDGPAHLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC TESHTGTSAFAPLAAGIIALTLEANKNLTWRDMQHLVVRTSKPAHLNANDWATNGVGRKV SHSYGYGLLDAGAMVALAQNWTTVAPQRKCTIDILTEPKDIGKRLEVRKTVTACLGEPSH ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPTPPESIGCKTLTSSQACVVCE EGFSLHQKNCVQHCPPGFAPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCL SCPSHASLDPVEQTCSRQSQSSRESHQQQPPPPPRPPPAEVATEPRLRADLLPSHLPEVV AGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEE DEGRGERTAFIKDQSAL |
| External Links | |
| GenBank ID Protein | CAA53569.1 |
| UniProtKB/Swiss-Prot ID | Q28193 |
| UniProtKB/Swiss-Prot Entry Name | FURIN_BOVIN |
| PDB IDs | |
| GenBank Gene ID | X75956 |
| GeneCard ID | FURIN |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |