Showing Protein Annexin A1 (BMDBP01318)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01318 |
| Secondary Accession Numbers | None |
| Name | Annexin A1 |
| Synonyms | Not Available |
| Gene Name | ANXA1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in calcium ion binding |
| Specific Function | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 8 |
| Locus | Not Available |
| SNPs | ANXA1 |
| Gene Sequence |
>1041 bp ATGGCAATGGTATCTGAATTCCTCAAGCAGGCCTGGTTTATTGAAAATGAAGAGCAGGAA TACATTAAAACGGTGAAAGGATCCAAAGGTGGTCCTGGGTCAGCAGTGAGCCCCTATCCT ACGTTCAATCCATCCTCGGATGTTGAGGCCTTGCACAAAGCAATCACAGTTAAAGGTGTG GATGAAGCAACCATCATTGAAATTCTGACTAAGAGAAACAATGCACAGCGTCAGCAGATC AAAGCGGCCTATCTGCAGGAGAAAGGAAAGCCCCTGGATGAAGTTCTGAAGAAAGCCCTC CTCGGTCACCTTGAGGAAGTTGTTTTGGCTCTATTGAAAACTCCAGCCCAGTTTGATGCC GAAGAGCTCCGTGCTGCCATGAAGGGCCTTGGGACTGATGAAGACACTCTGAATGAAATT CTGGCATCAAGAACTAACAGAGAGATCAGAGAAATTAACAGAGTCCATAGAGAAGAACTG AAGAGAGATCTGGCTAAAGACATCGCCTCAGACACATCTGGAGATTATGAGAAGGCTTTG CTTGCTCTTGCTAAGGGTGACCGATCCGAGGAGCTTGCTGTAAATGACGACTTGGCTGAT TCAGATGCCAGGGCCTTATATGAAGCAGGAGAAAGAAGAAAAGGGACAGATGTGAATGTG TTCACTACCATTCTTACCACCAGGAGCTATCCCCATCTCCGCAGAGTGTTTCAGAAATAT TCCAAGTATAGCAAGCATGACATGAACAAAGTTCTGGACCTGGAGTTGAAAGGTGACATC GAGAAATGCCTCACAGTTATTGTGAAGTGTGCTACAAGCCAGCCAATGTTCTTTGCTGAG AAGCTCCATCAGGCCATGAAGGGTATTGGAACTCGTCATAAGACACTGATCAGGATTATG GTTTCCCGCTCCGAAATTGACATGAATGACATCAAAGCATGCTATCAGAAGTTGTATGGC ATCTCTCTCTGTCAAGCCATCCTGGATGAAACCAAAGGAGATTATGAAAAAATCCTGGTG GCTCTCTGTGGAAGAGACTAA |
| Protein Properties | |
| Number of Residues | 346 |
| Molecular Weight | 38952.0 |
| Theoretical pI | 6.79 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Annexin A1 MAMVSEFLKQAWFIENEEQEYIKTVKGSKGGPGSAVSPYPTFNPSSDVEALHKAITVKGV DEATIIEILTKRNNAQRQQIKAAYLQEKGKPLDEVLKKALLGHLEEVVLALLKTPAQFDA EELRAAMKGLGTDEDTLNEILASRTNREIREINRVYREELKRDLAKDIASDTSGDYEKAL LSLAKGDRSEELAVNDDLADSDARALYEAGERRKGTDVNVFITILTTRSYPHLRRVFQKY SKYSKHDMNKVLDLELKGDIEKCLTVIVKCATSQPMFFAEKLHQAMKGIGTRHKTLIRIM VSRSEIDMNDIKACYQKLYGISLCQAILDETKGDYEKILVALCGRD |
| External Links | |
| GenBank ID Protein | 74 |
| UniProtKB/Swiss-Prot ID | P46193 |
| UniProtKB/Swiss-Prot Entry Name | ANXA1_BOVIN |
| PDB IDs | |
| GenBank Gene ID | X56649 |
| GeneCard ID | ANXA1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |