Showing Protein Hepatocyte growth factor-regulated tyrosine kinase substrate (BMDBP01319)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01319 |
| Secondary Accession Numbers | None |
| Name | Hepatocyte growth factor-regulated tyrosine kinase substrate |
| Synonyms | Not Available |
| Gene Name | HGS |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in zinc ion binding |
| Specific Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 19 |
| Locus | Not Available |
| SNPs | HGS |
| Gene Sequence |
>2334 bp ATGGGGCGTGGCAGTGGCACCTTCGAGCGTCTCCTAGACAAAGCGACCAGCCAGCTTCTT CTGGAGACTGACTGGGAGTCCATCCTCCAGATCTGTGACCTGATCCGCCAGGGGGACACG CAGGCAAAATATGCAGTGAGTTCCATCAAGAAGAAAGTTAATGATAAGAATCCCCACGTG GCCTTGTACGCCCTAGAGGTCATGGAGTCTGTGGTGAAGAATTGCGGCCAGACAGTCCAT GATGAGGTGGCAAACAAGCAGACCATGGAGGAGCTGAAGGATCTGCTGAAGAGGCAGGTG GAAGTAAACGTCCGGAACAAGATCCTGTATCTGATTCAGGCCTGGGCACACGCCTTCCGG AACGAGCCCAAGTACAAGGTGGTCCAGGACACGTACCAGATCATGAAGGTGGAAGGACAC GTCTTCCCAGAGTTCAAGGAAAGCGATGCCATGTTTGCTGCGGAGAGAGCCCCTGACTGG GTGGATGCTGAGGAGTGCCACCGGTGCCGGGTGCAGTTTGGGGTCATGACCCGCAAGCAC CACTGCCGGGCGTGTGGCCAGATCTTCTGCGGCAAGTGCTCTTCCAAGTACTCCACCATC CCCAAGTTCGGCATTGAGAAGGAGGTGCGGGTGTGTGAGCCCTGCTTTGAGCAGCTCAAC AAGAAAGCGGAGGGAAAAGCGGCCTCGACGACGGAGCTGCCCCCGGAGTACCTGACCAGC CCGCTGTCTCAGCAGTCGCAGCTGCCCCCTAAAAGGGATGAGACAGCCCTGCAGGAAGAG GAGGAGCTGCAGCTGGCCCTGGCCCTGTCTCAGTCGGAGGCCGAGGAGAAGGAACGGATG AGGCAGAAGTCGGCCTATACCGCGTACCCCAAGGCGGAACCCACGCCCGTGGCCTCCTCA GCACCCCCCGCCAGCAGCCTGTATTCTTCGCCTGTGAACTCGTCGGCGCCTCTGGCTGAG GACATCGATCCTGAGCTTGCGCGGTACCTGAACCGGAACTACTGGGAGAAGAAGCAGGAG GAGGCTCGGAAGAGCCCCACGCCGTCCGCGCCGGTGCCTCTGACAGAGCCCACGGCCCAG CCTGGGGAGGGACACGCAATCCCTGCCAACGTGGAGACTTCCCTCCCAGAGACAGACCCT CAGGCCGTAACTGCAGCCGGAGCTGCCTTTAGTGAGCAGTACCAGAATGGGGAGTCCGAG GAGAGCCACGCACAGTTCCTGAAGGCCCTCCAGAATGCCGTCACCACCTTCGTCAACCGC ATGAAGAGCAACCACGTGCGGGGCCGCAGCATCACCAACGACTCGGCCGTGCTGTCCCTC TTCCAGTCCATCAACACCATGCACCCCCAGCTGCTGGAGCTGCTCAACCAGCTGGATGAG CGCAGGTTATACTACGAGGGACTGCAGGACAAGCTGGCACAGATCCGTGATGCCCGGGGG GCACTCAGCGCCCTGCGGGAGGAGCACCGGGAGAAGCTTCGCCGCGCAGCTGAGGAGGCT GAGCGCCAGCGCCAGATCCAGCTGGCCCAGAAGCTGGAGATCATGCGGCAGAAGAAGCAG GAGTACTTAGAGGTGCAGCGGCAGCTGGCCATCCAGCGCCTGCAGGAGCAGGAGAAGGAG CGGCAAATGCGCCTGGAGCAGCAGAAGCAGACCATCCAGATGCGGGCCCAGATGCCCGCT TTCTCCCTGCCCTACGCCCAGCTCCAGGCCATGCCTGCAGCAGGGGGCGTGCTGTACCAG CCTTCCGGCCCGGCGAGCTTCGCGGGCACCTTCAGCCCGGCCGGCTCGGTGGAGGGCTCG CCCATGCACACCATGTACATGAGTCAGCCGGCCCCGGCTGCCAGCGGCCCCTACCCCAGC ATGCCAGCAGCCGCAGCAGACCCCAGCATGGTGAGCGCTTACATGTACCCAGCAGGGGCG GCTGGTGCACAGGCAGCCGCACAGGGCCCCGCAGGGCCCACCACCAGCCCAGCCTACTCA TCATACCAGCCTACTCCCACGCAGGGCTATCAGACCGTGGCCTCCCAGGCCCCACAGAGC CTCCCAGCCATCTCCCAGCCCCCGCAGTCTGGTACGATGGGCTACATGGGGAGCCAGTCA GTGTCCATGGGCTACCAGCCTTATAGCATGCAGAATCTCATGCCGACCCTCCCCGGCCAA GACGCGCCTCTGCCGCCCCCACAGCAACCCTATATCTCAGGGCAGCAGCCCGTGTACCAG CAGATGGCGCCCTCCAGCGGCCCTCCTCAGCAGCAGCCCCCAGTGGCCCAGCAGCCCCCA GCACAGGGCCCGCCAGCACAGGGCAGTGAAGCCCAGCTCATCTCGTTTGACTGA |
| Protein Properties | |
| Number of Residues | 777 |
| Molecular Weight | 85786.0 |
| Theoretical pI | 6.1 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Hepatocyte growth factor-regulated tyrosine kinase substrate MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVSSIKKKVNDKNPHV ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCFEQLNKKAEGKAASTTELPPEYLTS PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERMRQKSAYTAYPKAEPTPVASS APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPTAQ PGEGHAIPANVETSLPETDPQAVTAAGAAFSEQYQNGESEESHAQFLKALQNAVTTFVNR MKSNHVRGRSITNDSAVLSLFQSINTMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARG ALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKE RQMRLEQQKQTIQMRAQMPAFSLPYAQLQAMPAAGGVLYQPSGPASFAGTFSPAGSVEGS PMHTMYMSQPAPAASGPYPSMPAAAADPSMVSAYMYPAGAAGAQAAAQGPAGPTTSPAYS SYQPTPTQGYQTVASQAPQSLPAISQPPQSGTMGYMGSQSVSMGYQPYSMQNLMPTLPGQ DAPLPPPQQPYISGQQPVYQQMAPSSGPPQQQPPVAQQPPAQGPPAQGSEAQLISFD |
| External Links | |
| GenBank ID Protein | ABG66987.1 |
| UniProtKB/Swiss-Prot ID | Q0V8S0 |
| UniProtKB/Swiss-Prot Entry Name | HGS_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BT026148 |
| GeneCard ID | HGS |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |