Showing Protein Calpain-2 catalytic subunit (BMDBP01320)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01320 |
| Secondary Accession Numbers | None |
| Name | Calpain-2 catalytic subunit |
| Synonyms | Not Available |
| Gene Name | CAPN2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in calcium ion binding |
| Specific Function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 16 |
| Locus | Not Available |
| SNPs | CAPN2 |
| Gene Sequence |
>2103 bp ATGGCGGGCATCGCGGCCAAGCTGGCGAAGGACCGGGAGGCGGCCGAGGGGCTGGGCTCG CACGAGAGGGCGGTCAAGTACCTCAACCAGGACTACGCGGCGCTGCGGGACGAGTGCCTG GAGGCCGGGGCGCTGTTCCAGGACCCCTCCTTCCCGGCCCTGCCGTCCTCCCTGGGCTTC AAGGAGTTGGGACCTTACTCCAGCAAGACCCGGGGCATCGAGTGGAAGCGGCCCACGGAG ATCTGCGATAATCCCCAATTTATTACTGGAGGAGCCACTCGCACAGACATCTGCCAAGGA GCCCTAGGTGACTGCTGGCTGCTGGCCGCAATTGCCTCCCTCACTTTGAATGAAGAAATC CTGGCTCGAGTCGTCCCCCTGGACCAGAGCTTCCAGGAGAACTATGCGGGGATCTTCCAC TTCCAGTTCTGGCAGTACGGCGAGTGGGTGGAGGTGGTGGTGGACGACAGGCTGCCCACC AAGGACGGGGAGCTGCTCTTCGTGCACTCGGCAGAGGGCAGCGAGTTCTGGAGTGCGCTG CTGGAGAAGGCCTACGCCAAGATCAATGGGTGTTATGAAGCACTTTCGGGGGGCGCCACC ACTGAGGGCTTCGAGGACTTCACTGGAGGCATCGCTGAGTGGTATGAGTTGAGGAAGGCC CCTCCCAACCTGTTCAGGATCATCCAGAAGGCTCTGCAGAAAGGCTCTCTCCTGGGCTGC TCCATCGATATCACCAGCGCTGCGGACTCGGAGGCCATCACGTTCCAGAAGCTGGTGAAG GGGCACGCGTACTCGGTGACCGGTGCCGAGGAGGTGGAAAGCAGAGGAAGCCTGCAGAAG CTGATCCGCATCCGGAATCCCTGGGGAGAGGTGGAGTGGACCGGGCAGTGGAATGACAAC TGCCCAAACTGGAACACAGTCGACCCCGAGGTGAGGGAAACGCTGACTAGACAGCATGAG GATGGGGAATTCTGGATGTCTTTCAACGACTTCCTGAGACACTATTCCCGCCTGGAAATC TGCAACCTGACCCCTGACACACTCACCAGTGACAGCTACAAGAAGTGGAAACTCACCAAG ATGGATGGGAACTGGAGGCGGGGCTCCACCGCGGGCGGCTGCAGGAACTACCCGAACACG TTCTGGATGAATCCTCAGTACCTGATCAAGCTGGAGGAAGAGGACGAGGACCAGGAGGAC GGGGAGAGCGGCTGCACCTTCCTGGTGGGCCTCATCCAGAAGCACCGGCGGCGGCAGAGG AAGATGGGCGAGGACATGCACACCATTGGCTTCGGCATCTATGAGGTTCCAGAGGAGTTG ACTGGACAGACCAACATCCACCTCAGCAAAAAATTCTTCCTGACAACCAGAGCGCGGGAG CGGTCGGACACCTTCATCAACCTGCGGGAGGTGCTCAACCGCTTCAAGCTGCCCCCCGGG GAGTACATCGTGGTGCCCTCCACCTTCGAGCCCAACAAGGACGGCGACTTCTGCATCCGG GTCTTTTCCGAGAAGAAAGCCGACTACCAAGTTGTCGACGATGAAATCGAGGCCAACATT GACGAGATTGACATCAGCGAGGATGACATCGATGATGGATTCAGGAGACTGTTCGCCCAG CTGGCCGGAGAGGACGCAGAGATTTCTGCCTTTGAGTTGCAGACAATCCTGAGAAGAGTG CTAGCAAAGCGCCAAGATATCAAGTCCGACGGCTTTAGCATTGAGACCTGCAAAATCATG GTGGACATGCTCGACTCGGATGGGAGTGGCAAACTGGGTCTGAAGGAGTTCTACATTCTC TGGACGAAGATTCAGAAATACCAAAAAATTTACCGGGAAATTGATGTGGACCGGTCTGGA ACCATGAACTCCTATGAGATGCGGAAAGCATTAGAAGAAGCAGGTTTCAAGATGCCCTGT CAGCTCCACCAAGTGATTGTCGCCCGGTTTGCAGATGACGACCTCATCATCGATTTTGAC AATTTTGTCCGGTGTTTGATTCGACTGGAGACACTGTTCAGGATATTTAAGCAGCTGGAC CCCGAGAATACTGGAATGATCCAGCTTGACCTTATCTCTTGGCTGTCTTTTTCAGTACTT TGA |
| Protein Properties | |
| Number of Residues | 700 |
| Molecular Weight | 79935.0 |
| Theoretical pI | 4.59 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Calpain-2 catalytic subunit MAGIAAKLAKDREAAEGLGSHERAVKYLNQDYAALRDECLEAGALFQDPSFPALPSSLGF KELGPYSSKTRGIEWKRPTEICDNPQFITGGATRTDICQGALGDCWLLAAIASLTLNEEI LARVVPLDQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELRKAPPNLFRIIQKALQKGSLLGC SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESRGSLQKLIRIRNPWGEVEWTGQWNDN CPNWNTVDPEVRETLTRQHEDGEFWMSFNDFLRHYSRLEICNLTPDTLTSDSYKKWKLTK MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDQEDGESGCTFLVGLIQKHRRRQR KMGEDMHTIGFGIYEVPEELTGQTNIHLSKKFFLTTRARERSDTFINLREVLNRFKLPPG EYIVVPSTFEPNKDGDFCIRVFSEKKADYQVVDDEIEANIDEIDISEDDIDDGFRRLFAQ LAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYIL WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDDLIIDFD NFVRCLIRLETLFRIFKQLDPENTGMIQLDLISWLSFSVL |
| External Links | |
| GenBank ID Protein | AAI34527.1 |
| UniProtKB/Swiss-Prot ID | Q27971 |
| UniProtKB/Swiss-Prot Entry Name | CAN2_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BC134526 |
| GeneCard ID | CAPN2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |