| Identification |
|---|
| BMDB Protein ID
| BMDBP01328 |
| Secondary Accession Numbers
| None |
| Name
| Profilin-1 |
| Synonyms
|
Not Available
|
| Gene Name
| PFN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in actin binding |
| Specific Function
| Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| PFN1 |
| Gene Sequence
|
>423 bp
ATGGCCGGGTGGAACGCCTACATCGACAACCTCATGGCGGACGGGACCTGTCAGGACGCA
GCCATCGTGGGCTATAAGGACTCGCCCTCCGTCTGGGCCGCCGTCCCCGGCAAGACCTTC
GTCAACATCACGCCTGCTGAGGTCGGTATCCTGGTTGGCAAAGACCGGTCAAGTTTTTTC
GTGAACGGGCTAACACTTGGGGGCCAGAAATGTTCTGTGATCCGGGACTCACTGCTGCAG
GATGGAGAATTTACCATGGATCTTCGTACCAAGAGCACCGGTGGAGCCCCAACCTTCAAT
ATCACGGTCACCATGACTGCCAAGACGCTAGTCCTGCTGATGGGCAAAGAAGGTGTCCAC
GGCGGTATGATCAACAAGAAATGTTATGAAATGGCTTCTCACCTGCGGCGTTCCCAGTAC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 140 |
| Molecular Weight
| 15057.0 |
| Theoretical pI
| 8.47 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Profilin-1
MAGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGILVGKDRSSFF
VNGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTGGAPTFNITVTMTAKTLVLLMGKEGVH
GGMINKKCYEMASHLRRSQY
|
| External Links |
|---|
| GenBank ID Protein
| AAX09095.1 |
| UniProtKB/Swiss-Prot ID
| P02584 |
| UniProtKB/Swiss-Prot Entry Name
| PROF1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BT021078 |
| GeneCard ID
| PFN1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
