| Identification |
|---|
| BMDB Protein ID
| BMDBP01332 |
| Secondary Accession Numbers
| None |
| Name
| Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| ASAP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell wall/membrane/envelope biogenesis |
| Specific Function
| Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. Plays a role in ciliogenesis (By similarity). May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| ASAP1 |
| Gene Sequence
|
>3390 bp
ATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCATCAAGAGATTCGCTATGGAATCGG
ATGCCGGACCAGATCTCCGTCTCCGAGTTCATCGCCGAGACCACCGAGGACTACAACTCG
CCCACCACGTCCAGCTTCACTACGCGGCTGCACAACTGCAGGAACACCGTCACGCTGCTG
GAGGAGGCTCTAGACCAAGATAGAACAGCCTTACAGAAAGTTAAGAAGTCTGTAAAAGCA
ATATACAATTCCGGTCAAGACCATGTACAAAATGAAGAAAACTATGCGCAAGTTCTTGAT
AAGTTTGGGAGTAATTTTTTAAGTCGAGACAACCCAGATCTTGGCACCGCTTTTGTCAAG
TTTTCTACGCTTACAAAGGAACTGTCCACACTGCTGAAAAATCTGCTCCAGGGCCTGAGC
CACAATGTGATCTTCACCTTGGATTCCTTGTTGAAAGGAGACCTGAAGGGAGTCAAAGGC
GATCTCAAGAAACCATTTGACAAAGCTTGGAAAGATTATGAGACGAAGTTTACCAAAATT
GAGAAGGAGAAGAGGGAGCACGCCAAGCAGCACGGGATGATCCGCACGGAGATCACCGGC
GCCGAGATCGCGGAGGAAATGGAAAAGGAGCGGCGCCTCTTCCAGCTCCAGATGTGCGAG
TATCTCATTAAAGTTAATGAAATCAAGACCAAAAAGGGTGTGGATCTGCTGCAGAACCTG
ATAAAGTATTATCACGCACAGTGCAATTTCTTTCAAGATGGTTTGAAAACAGCTGATAAA
TTGAAACAGTACATTGAAAAGCTGGCTGCTGATTTGTATAATATCAAACAGACCCAGGAC
GAAGAAAAGAAACAGCTGACCGCACTCCGAGACCTAATAAAGTCCTCGCTCCAACTCGAT
CAGAAGGAGTCTAGGAGAGATTCCCAGAGCCGGCAGGGAGGCTACAGCATGCACCAGCTG
CAGGGCAACAAGGAATACGGCAGCGAGAAGAAGGGCTACCTGCTGAAGAAGAGTGACGGG
ATCCGGAAAGTGTGGCAGAGAAGGAAGTGCTCCGTCAAGAACGGGATCCTGACCATCTCC
CACGCCACGTCCAACAGACAGCCAGCCAAGCTGAACCTTCTCACTTGCCAGGTGAAGCCG
AATGCCGAGGACAAGAAGTCTTTTGACCTGATATCACATAACAGGACGTATCACTTTCAG
GCCGAAGATGAGCAGGATTATGTAGCGTGGATCTCGGTGCTGACAAACAGCAAAGAGGAG
GCCCTCACCATGGCCTTCCGGGGGGAACAGAGTGCTGGGGAGAGCAGCCTGGAGGAGCTG
ACGAAGGCCATCATCGAGGACGTGCAGCGGCTCCCGGGCAACGACGTCTGCTGCGACTGC
GGCTCGGCAGAACCCACCTGGCTGTCCACCAACTTGGGCATCTTGACCTGTATAGAATGT
TCCGGCATCCATAGAGAAATGGGGGTTCATATTTCTCGCATCCAGTCTTTGGAACTAGAC
AAATTAGGAACTTCTGAACTCTTGCTGGCCAAGAATGTAGGAAACAATAGTTTTAATGAT
ATTATGGAAGCAAATTTACCCAGTCCCTCACCAAAACCCACCCCTTCAAGTGATATGACT
GTACGGAAGGAATATATCACTGCAAAGTATGTAGATCATAGGTTTTCACGGAAGACCTGT
TCATCGTCATCAGCTAAACTGAACGAATTGCTTGAGGCCATCAAATCCAGGGATTTACTT
GCACTAATTCAAGTCTATGCAGAGGGGGTGGAGCTAATGGAACCGCTGCTGGAACCCGGA
CAGGAGCTTGGGGAGACAGCCCTTCATCTTGCAGTCCGAACCGCAGACCAGACATCTCTC
CATTTGGTGGACTTCCTTGTACAAAACTGTGGGAACCTAGATAAGCAGACGGCCCTGGGG
AACACGGCCCTGCACTACTGTAGTATGTACAGTAAACCAGAGTGTTTGAAGCTGCTGCTC
AGGAGCAAGCCCACTGTGGACGTCGTTAATCAGGCTGGAGAGACCGCCCTGGACATAGCA
AAGAGACTGAAAGCCACTCAGTGTGAAGACCTGCTTTCCCAAGCTAAATCTGGAAAGTTC
AATCCACACGTCCACGTGGAATATGAGTGGAATCTTCGACAGGAGGAGATGGATGAGAGC
GATGACGACCTGGATGACAAACCGAGCCCCATCAAGAAGGAGCGCTCCCCCCGACCGCAG
AGCTTCTGCCACTCCTCCAGCATCTCCCCCCAGGACAAGCTCTCACTGCCGGGCTTCAGC
ACGCCAAGGGACAAGCAACGACTCTCCTACGGCGCCTTCACCAACCAGATCTTCGTCTCC
ACAAGCACAGACTCACCCACGTCACCGATCGCAGAGGCGCCCCCGCTGCCTCCCAGAAAC
GCCACGAAAGGTCCACCTGGCCCACCTTCAACACTCCCTCTAAGCACCCAGACCTCTAGT
GGCAGCTCCACCCTGTCCAAGAAGCGGTCTCCTCCCCCACCACCCGGACACAAGAGAACC
CTGTCTGACCCTCCCAGCCCACTACCTCACGGGCCCCCAAACAAAGGCGCAGTTCCTTGG
GGTAACGACGTGGGTCCCTCATCGTCCAGTAAGACCACGAACAAGTTCGAGGGCCTGTCC
CAGCAGTCGAGCACCGGTTCTGCAAAGACTGCACTTGGCCCAAGAGTTCTTCCTAAACTA
CCTCAGAAAGTGGCACTAAGGAAAACAGAGACCAGCCATCATCTCTCCCTCGACAAAGCC
AACGTCCCACCTGAGATCTTCCAGAAGTCGTCCCAGTTGACAGAGTTACCGCAGAAGCCG
CCACCCGGGGACCTGCCCCCGAAGCCCACGGAACTGGCTCCCAAACCCCCCATTGGAGAC
TTACCACCTAAGCCAGGCGAGCTGCCCCCGAAGCCACAGCTGGGCGACCTGCCCCCCAAG
CCCCAGCTCGCAGACTTGCCCCCCAAGCCCCAGGTGAAAGACCTGCCTCCCAAGCCACAA
CTGGGGGAGCTGCTGGCAAAACCCCAGACGGGAGACGCCTCGCCCAAGGCCCAGCCACCC
CTGGAGCTCACCCCCAAGTCACACCCGGCGGACCTGTCCCCGAACGTCCCCAAGCAGGCG
TCTGAGGACACCAACGACCTCACGCCCACCCTGCCAGAGACACCCGTGCCTCTGCCCAGG
AAGATCAACACGGGGAAGAGCAAGGTGAGGCGAGTGAAGACCATCTACGACTGCCAGGCG
GACAACGATGACGAGCTGACTTTCATGGAGGGCGAGGTGATCGTGGTCACCGGGGAGGAG
GACCAGGAGTGGTGGATTGGGCACATCGAGGGGCAGCCCGAGAGGAAGGGCGTCTTCCCA
GTGTCCTTTGTCCACATCCTGTCGGACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1129 |
| Molecular Weight
| 125382.0 |
| Theoretical pI
| 7.58 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
QKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS
HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE
ALTMAFRGEQSAGESSLEELTKAIIEDVQRLPGNDVCCDCGSAEPTWLSTNLGILTCIEC
SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT
VRKEYITAKYVDHRFSRKTCSSSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG
QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTALHYCSMYSKPECLKLLL
RSKPTVDVVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEMDES
DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLSLPGFSTPRDKQRLSYGAFTNQIFVS
TSTDSPTSPIAEAPPLPPRNATKGPPGPPSTLPLSTQTSSGSSTLSKKRSPPPPPGHKRT
LSDPPSPLPHGPPNKGAVPWGNDVGPSSSSKTTNKFEGLSQQSSTGSAKTALGPRVLPKL
PQKVALRKTETSHHLSLDKANVPPEIFQKSSQLTELPQKPPPGDLPPKPTELAPKPPIGD
LPPKPGELPPKPQLGDLPPKPQLADLPPKPQVKDLPPKPQLGELLAKPQTGDASPKAQPP
LELTPKSHPADLSPNVPKQASEDTNDLTPTLPETPVPLPRKINTGKSKVRRVKTIYDCQA
DNDDELTFMEGEVIVVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
|
| External Links |
|---|
| GenBank ID Protein
| AAD19965.1 |
| UniProtKB/Swiss-Prot ID
| O97902 |
| UniProtKB/Swiss-Prot Entry Name
| ASAP1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF112886 |
| GeneCard ID
| ASAP1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
