Showing Protein Retinoid isomerohydrolase (BMDBP01341)
| Identification | |||||
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| BMDB Protein ID | BMDBP01341 | ||||
| Secondary Accession Numbers |
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| Name | Retinoid isomerohydrolase | ||||
| Synonyms | Not Available | ||||
| Gene Name | RPE65 | ||||
| Protein Type | Enzyme | ||||
| Biological Properties | |||||
| General Function | Secondary metabolites biosynthesis, transport and catabolism | ||||
| Specific Function | Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16096063, PubMed:19805034, PubMed:20100834). Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (PubMed:15186777). | ||||
| Pathways | Not Available | ||||
| Reactions |
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| GO Classification | Not Available | ||||
| Cellular Location | Not Available | ||||
| Gene Properties | |||||
| Chromosome Location | 3 | ||||
| Locus | Not Available | ||||
| SNPs | RPE65 | ||||
| Gene Sequence |
>1602 bp ATGTCCAGCCAAGTTGAACATCCAGCTGGTGGTTACAAGAAACTGTTTGAAACTGTGGAG GAACTATCCTCACCGCTCACAGCCCATGTTACAGGCAGGATCCCCCTCTGGCTAACCGGC AGTCTCCTTCGATGTGGGCCAGGACTCTTTGAGGTTGGATCGGAACCATTTTACCACCTG TTTGATGGGCAAGCCCTCCTACACAAGTTTGACTTTAAAGAAGGACATGTCACATACCAC AGAAGGTTCATCCGCACTGATGCTTACGTACGGGCAATGACTGAGAAAAGGATCGTCATA ACAGAATTTGGCACCTGTGCTTTCCCAGATCCCTGCAAGAATATATTTTCCAGGTTTTTT TCTTACTTCCGAGGAGTGGAGGTTACTGACAATGCCCTTGTTAATATCTACCCAGTGGGG GAAGATTACTATGCCTGCACAGAGACCAACTTCATTACAAAGGTTAATCCTGAGACCTTG GAAACAATTAAGCAGGTTGACCTTTGCAACTATGTCTCAGTCAATGGAGCCACTGCTCAC CCCCACATTGAAAATGATGGGACTGTTTACAACATTGGTAATTGCTTTGGGAAAAATTTT TCAATTGCCTACAATATTGTAAAGATCCCACCACTACAAGCAGACAAGGAAGATCCAATA AGCAAGTCAGAGATCGTTGTACAATTCCCCTGCAGTGACCGATTCAAGCCATCTTACGTC CATAGTTTTGGTTTGACTCCCAACTATATTGTTTTTGTGGAGACACCAGTCAAAATTAAT CTGTTCAAGTTTCTTTCTTCATGGAGTCTTTGGGGAGCCAATTACATGGATTGTTTTGAA TCCAATGAAACCATGGGGGTTTGGCTTCATATTGCTGACAAAAAAAGAAAAAAGTATATC AATAATAAATACAGGACCTCTCCTTTTAACCTCTTTCATCACATCAATACCTATGAAGAC CATGAGTTTCTGATTGTGGATCTCTGTTGCTGGAAAGGATTTGAATTTGTTTATAATTAT TCATATTTAGCCAATTTACGTGAGAACTGGGAAGAGGTGAAAAAAAATGCCAGAAAGGCT CCTCAGCCTGAAGTTAGGAGATACGTACTTCCTTTGAATATTGACAAGGCTGACACAGGC AAGAATTTAGTCACACTCCCCAACACAACTGCCACTGCAATTCTGTGCAGTGACGAGACC ATCTGGCTGGAACCTGAGGTTCTCTTTTCAGGGCCTCGCCAAGCATTTGAGTTTCCTCAA ATCAATTACCAGAAGTATGGTGGGAAACCTTACACATATGCATATGGACTTGGCTTGAAT CACTTTGTTCCAGACAGGCTCTGTAAGCTGAACGTCAAAACTAAAGAAACCTGGGTATGG CAAGAGCCTGATTCATACCCCTCAGAACCTATCTTTGTTTCTCACCCAGATGCCTTGGAG GAAGATGACGGTGTAGTTCTGAGTGTGGTGGTGAGCCCTGGGGCAGGACAAAAGCCTGCT TATCTTCTGATTCTGAATGCCAAGGACTTGAGTGAAGTTGCCAGGGCTGAAGTGGAGATT AACATCCCCGTCACCTTTCATGGACTGTTCAAAAAATCCTGA |
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| Protein Properties | |||||
| Number of Residues | 533 | ||||
| Molecular Weight | 60944.0 | ||||
| Theoretical pI | 6.41 | ||||
| Pfam Domain Function | Not Available | ||||
| Signals |
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| Transmembrane Regions | Not Available | ||||
| Protein Sequence |
>Retinal pigment epithelium-specific 65 kDa protein MSSQVEHPAGGYKKLFETVEELSSPLTAHVTGRIPLWLTGSLLRCGPGLFEVGSEPFYHL FDGQALLHKFDFKEGHVTYHRRFIRTDAYVRAMTEKRIVITEFGTCAFPDPCKNIFSRFF SYFRGVEVTDNALVNIYPVGEDYYACTETNFITKVNPETLETIKQVDLCNYVSVNGATAH PHIENDGTVYNIGNCFGKNFSIAYNIVKIPPLQADKEDPISKSEIVVQFPCSDRFKPSYV HSFGLTPNYIVFVETPVKINLFKFLSSWSLWGANYMDCFESNETMGVWLHIADKKRKKYI NNKYRTSPFNLFHHINTYEDHEFLIVDLCCWKGFEFVYNYSYLANLRENWEEVKKNARKA PQPEVRRYVLPLNIDKADTGKNLVTLPNTTATAILCSDETIWLEPEVLFSGPRQAFEFPQ INYQKYGGKPYTYAYGLGLNHFVPDRLCKLNVKTKETWVWQEPDSYPSEPIFVSHPDALE EDDGVVLSVVVSPGAGQKPAYLLILNAKDLSEVARAEVEINIPVTFHGLFKKS |
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| External Links | |||||
| GenBank ID Protein | AAC37306.1 | ||||
| UniProtKB/Swiss-Prot ID | Q28175 | ||||
| UniProtKB/Swiss-Prot Entry Name | RPE65_BOVIN | ||||
| PDB IDs | |||||
| GenBank Gene ID | L11356 | ||||
| GeneCard ID | RPE65 | ||||
| GenAtlas ID | Not Available | ||||
| HGNC ID | Not Available | ||||
| References | |||||
| General References | Not Available | ||||