| Identification |
|---|
| BMDB Protein ID
| BMDBP01348 |
| Secondary Accession Numbers
| None |
| Name
| Testis anion transporter 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SLC26A8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 23 |
| Locus
| Not Available |
| SNPs
| SLC26A8 |
| Gene Sequence
|
>2883 bp
ATGCAGCCAGACAGGAGCTTCCAGAGTTTTGCCTCTAGGTACAGGCAAAGTTCTTTCACA
TATGATGTGAAGCGAGACGTGTACAATGAGGAAAATTTTCAACAGGAACACAGAAAGAAG
ACCGCCTCCTCTGGGAACGTGGACATCGACATCAGCACCGTCAGTCACCATGTGCAGTGC
AGATGCTCATGGCACAAGTTCCGAAGATGCCTGCTTACAGTGTTTCCCTTCCTAGAGTGG
ATGTGTTTCTATCGATTCAAAGATTGGCTTCTTGGAGACTTACTTGCTGGTATAAGTGTT
GGCCTTGTGCAAATTCCCCAAGTCCTGATGCTTGGTTTGCTGGCAAGGCATCTGATTCCT
CCTCTCAATGTCTCTTATGCAGCTTTCTGTGCTTCAGTAATTTATGGAATTTTTGGATCA
TGTCATCAAATGTCCATTGGTACATTCTTCCTTGTGAGTGCTCTGGCAATCAATGTCCTG
AGGACACAGCCATTCAACAGGGGCCACTTATTACTGGGAACTTTCATCCAGGCTGACTTT
TCTAACACGTCCTTCTATGAGAACTATAACAGATCCTTGAGTTCTGTGGCATCTGTAACT
TTGCTGACTGGGATTATTCAGCTGTCTATGGGCATGTTAGGTTTTGGCTTCATTGTCGCT
TACATTCCGGAGGCTGCAATTAGTGCTTACCTGGCTGCCACAGCCCTGCACGTTATGCTG
TCCCAGTTGACCTGCATCTTCGGAATTATGATCAGTTACAATTCTGGTCCCATCGCCTTC
TTCTACAACATAATTAACTACTGTTTAGGTCTCCCAAAAGCTAATTCCACCAGCATCTTA
CTATTTCTAACCGCTATGGTTGCTCTGAGAATCAACAAATGTATCAGAATTTCCTTCAAT
GAGTACCCCATTGAATTTCCCATGGAAGTGTTTCTGGTTCTTGGCTTCGCTGCATTTTCA
AACAAGGTAAACATGGCCACAGAAAACAGCCTGATGCTCATGGAGATGATACCTTATAGC
TTCCTGTTTCCTGTAACGCCAGATATGAGCAATCTTACTGAAGTTCTTATAGAATCGTTC
TCCTTAGCTTTAGTGAGCTCCTCTTTGCTCGTATTTCTGGGCAAGAAGATTGCCAGTTTC
CATAACTATGACGTCAATTCCAACCAGGATTTAATAGCCATTGGCCTTTGCAATGTCGTC
AGTTCATTTTTCAGATCTTACGTGTTTACTGGTGCTGTTGCCAGGACCATTATCCAGGAT
AAAACTGGAGGACGACAACAGTTTGCATCTCTGGTAGGCGCAGGCATCATGCTGCTCCTG
ATGATGAAGATGGCACGCTTTTTCTACAGACTGCCAAACGCTATAGTGGCTGGTATTATC
CTGAGTAATGTCCTACCCTACCTTGAAGCTGTTTACACCCTACCCAGTCTGTGGAGGCAG
AACCAGTATGACTGTCTCATTTGGATGGTGACGTTCATGTCTGCAATTTTACTGGGACTG
GATATTGGACTAGTTGTTGCAGTAACTTTTGCCTTCTTCATCATCACTGTTCAGTCACAC
AGAACTAAGATTCTCCTCCTGGGTCAGATCCCTAACACCAATATTTATAGAAGCTTCCAA
GACTATCGGGAGGTTGCAAACATTCCAGGGGTGAAGATCTTCCAGTGCTGCAATGCCATC
ACATTTGTCAATGTTCACTACCTCAAGCGCAAGGTGTTAGAGGAGATTGAAATGGTAAAG
ATGCCTCTTACAGAAGAGGAAATTTATACCCTGTTCAGTCAAAATGAAGAGGGTGCACAG
CGAGGAAAGATTTGTCGGTGTTACTGCAACTGTGATGAACCAGAGCCATCGCCCAGGGTT
ATTTACACAGAACGATATGAAGTTCAACGGGGCCGAGAGTCCTCCTTCATTAACCTGGTC
CGCTGCTCACGTTTTGAGAGCATGAACACAGCCCAAACTATGTCTGAAGACCAAGTACCG
TACATAACATCTTCCTCATCTCAGAGAAACCCAAACTATGAGGAGGTGGAGAAAGTTTGG
CTTTCTGATGACCCCTCCAGGAGCATGACGATCACACTCCCTGAGGCTTCTGATACTCAG
GTCAGGGCTACAAAACTCCTGCCTTACTCGACTTCAACTATTCTACCCAGCATCCACACC
ATCATCTTGGACTTCTCCATGGTACATCTTGTGGACGCACGGGCTTTGGTTGTATTAAGA
CAGATGTTCAGCGCTTTCCAAAACGCCAACATCTTGGTGCTCATTGCAGGGTGTCACTCT
TTTGTGGTCAGGTCACTTGAGAAGAATGATTTCTTTGACGCTGGCATCACTAAGGCCCAG
CTGTTCCTCACCCTCCACGATGCTGTGCTATTTGCTTTGTCAAGGAAGTTGCCAGAGTCC
TCCGAGTTAAGTGTGGACGAATCAGAGACTGTCATACAGGAAACCTTCTCAGAGACAGAC
AAGAAAGAAGAATCAAGACATAAAACAAACAGAAGTCTTATAGAAGCCCCCAGAAGTAAA
AGTCCAGGCTTCTCCTTACTCCCAGACCCAGAGATGGAGGAGGAATCAGACTTGGATCTA
TATTCCACGATACAGATGTCTAAAGACCATGGGCTGGATCTGGACCTAGACCTGGATCGT
GAGGTGGAGCCTGAGTCAGAGCTGGAGCCTGAATCCGAGCTGGATCAAGAGACAGAGCTC
GAGCCTGAGCCAGAGGCCAGTCCCAAGCCGAATAGGCAGAAGTACTGGTCTCTGTTTAGG
GCTATAATTCCCAGATCCCCAACTCAGACTCAGGCTAGGACACAGTCAGTAGACAGGAGA
CATCAAAATGTGAAACCATATACATCCAAGGCTGACACCAGTGAGGATGCCTTGGAGATC
TAG
|
| Protein Properties |
|---|
| Number of Residues
| 960 |
| Molecular Weight
| 108744.0 |
| Theoretical pI
| 5.56 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 94-114
- 118-138
- 140-160
- 202-222
- 223-243
- 269-289
- 354-374
- 391-411
- 428-448
- 454-474
- 495-515
|
| Protein Sequence
|
>Testis anion transporter 1
MQPDRSFQSFASRYRQSSFTYDVKRDVYNEENFQQEHRKKTASSGNVDIDISTVSHHVQC
RCSWHKFRRCLLTVFPFLEWMCFYRFKDWLLGDLLAGISVGLVQIPQVLMLGLLARHLIP
PLNVSYAAFCASVIYGIFGSCHQMSIGTFFLVSALAINVLRTQPFNRGHLLLGTFIQADF
SNTSFYENYNRSLSSVASVTLLTGIIQLSMGMLGFGFIVAYIPEAAISAYLAATALHVML
SQLTCIFGIMISYNSGPIAFFYNIINYCLGLPKANSTSILLFLTAMVALRINKCIRISFN
EYPIEFPMEVFLVLGFAAFSNKVNMATENSLMLMEMIPYSFLFPVTPDMSNLTEVLIESF
SLALVSSSLLVFLGKKIASFHNYDVNSNQDLIAIGLCNVVSSFFRSYVFTGAVARTIIQD
KTGGRQQFASLVGAGIMLLLMMKMARFFYRLPNAIVAGIILSNVLPYLEAVYTLPSLWRQ
NQYDCLIWMVTFMSAILLGLDIGLVVAVTFAFFIITVQSHRTKILLLGQIPNTNIYRSFQ
DYREVANIPGVKIFQCCNAITFVNVHYLKRKVLEEIEMVKMPLTEEEIYTLFSQNEEGAQ
RGKICRCYCNCDEPEPSPRVIYTERYEVQRGRESSFINLVRCSRFESMNTAQTMSEDQVP
YITSSSSQRNPNYEEVEKVWLSDDPSRSMTITLPEASDTQVRATKLLPYSTSTILPSIHT
IILDFSMVHLVDARALVVLRQMFSAFQNANILVLIAGCHSFVVRSLEKNDFFDAGITKAQ
LFLTLHDAVLFALSRKLPESSELSVDESETVIQETFSETDKKEESRHKTNRSLIEAPRSK
SPGFSLLPDPEMEEESDLDLYSTIQMSKDHGLDLDLDLDREVEPESELEPESELDQETEL
EPEPEASPKPNRQKYWSLFRAIIPRSPTQTQARTQSVDRRHQNVKPYTSKADTSEDALEI
|
| External Links |
|---|
| GenBank ID Protein
| AAI49037.1 |
| UniProtKB/Swiss-Prot ID
| A6QNW6 |
| UniProtKB/Swiss-Prot Entry Name
| S26A8_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC149036 |
| GeneCard ID
| SLC26A8 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
