Showing Protein Solute carrier family 22 member 1 (BMDBP01355)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01355 |
| Secondary Accession Numbers | None |
| Name | Solute carrier family 22 member 1 |
| Synonyms | Not Available |
| Gene Name | SLC22A1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Carbohydrate transport and metabolism |
| Specific Function | Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 9 |
| Locus | Not Available |
| SNPs | SLC22A1 |
| Gene Sequence |
>1692 bp ATGCTCACTGTAGATGATGTACTGGAGCAGGTTGGGGAGTTCGGTTGGTTCCAGAAGCAA ACCTTCCTGATCCTGTGCCTGCTCTCGGCCGCCTTCGCCCCCATCTACGTGGGCATCGTC TTCCTGGCCTTCACCCCGGACCACCGCTGCCGGAGCCCCGGGGTGGCGGAGCTGAGCCGG CGATGCGGCTGGAGCCTGGCGGAGGAGCTCAACTACACGGTGCCAGGCCCGGGACCCGAG AGCCAGTGCCTCCGCTACGAGGTGGACTGGAACCAGAGCACCCTTGGCTGCCTGGACCCG CTGGCCAGCCTGGCTACCAACGGCAGCCCCCTGCCCCTGGGCCCCTGCGAGCAGGGCTGG GTGTACGACACGCCCGGCTCCTCCATCGTGACCGAGTTTAACCTGGTGTGTGATGACTCT TGGAAGGTGGACCTCTTTCAGTCCTGTGTGAACTTGGGCTTCTTCCTGGGCTCTCTGGGA GTCGGCTACATCGCAGACAGGTTTGGCCGCAAGGTGTGCCTCTTGGCTACCACCCTCACC TGCGCCAGCTTGGGCGTCCTGACGGCCGTGGCTCCGGACTACACGTCCCTGCTGATCTTC CGCCTGCTGCAGGGGCTGGTCAGCAAGGGCAGCTGGACGGCTGGCTACACCCTGATCACG GAGTTCGTGGGCCTGGGCTACAGACGGACAGTGGCGATCCTCTACCAGATGGCCTTCACC GTGGGGCTGGTGCTGCTCTCCGGACTGGCCTACATCCTCCCGCACTGGCGCTGGCTGCAG CTGGCCGTCTCCCTGCCCATCTTCCTGCTCCTCTTCCGCTTCTGGTTTGTGCCCGAGTCC CCCCGATGGCTGTTATCGCAAAAGAGAAACACTGAGGCGATAAAGATCATGGACCACATT GCGCAAAAGAACGGGAAGCTGCCTCCTGCTGACCTGAAGATGCTGTCTCTCGAGGAGGAC GTCACTGAGAAGCTGAGCCCCTCATTCATAGACCTGTTCCGCACGCCCAACCTGAGGAAG TACACCTTCATCCTGATGTACCTGTGGTTCACCAGCTCCGTGGTCTACCAGGGCCTCATC ATGCACGTGGGCGCCACCGGCGGGAACCTCTACCTGGACTTCCTCTACTCCGCTCTGGTC GAGTTCCCCGCAGGCTTCATCATCCTCGTCACCATCGACCGCTTCGGCCGCCGCTACCCG CTGGCCACGTCCAACTTGGCGGCCGGGCTGGCCTGCTTCCTCATGATCTTTATCCCACAC GATCTGCCCTGGTTGAATATCATGGTAGCTTGTGTTGGCAGAATGGGGATCACCATCGTG TTCCAGATGGTGTGCCTGGTCAACGCCGAGCTGTTCCCGACCTTCATCCGGAACCTTGGC ATGATGGTGTGTTCCTCCCTGTGTGATTTGGGTGGGGTTCTCACCCCGTTCCTGGTCTTC AGGCTGATGGAGGTTTGGCAAGGCTCGCCGCTCATTTTGTTTGCGGCCTTGGGGCTGGTT GCCGGGGGAATGACGCTGCTTCTTCCGGAGACCAAGGGGGTCACTTTGCCAGAGACCATC GAGGATGCCGAGAACCTGCAGAGGAAAGCAAAACCCAAAGAAAACAAGATTTACCTTCAG GTTCAAACATCAGAACTCAACACACAGGCAGCCGAGAGAGATGCTTCGCAGGGGACCGCG CAGCAGAAGTGA |
| Protein Properties | |
| Number of Residues | 563 |
| Molecular Weight | 62502.0 |
| Theoretical pI | 5.77 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Solute carrier family 22 member 1 MLTVDDVLEQVGEFGWFQKQTFLILCLLSAAFAPIYVGIVFLAFTPDHRCRSPGVAELSR RCGWSLAEELNYTVPGPGPESQCLRYEVDWNQSTLGCLDPLASLATNGSPLPLGPCEQGW VYDTPGSSIVTEFNLVCDDSWKVDLFQSCVNLGFFLGSLGVGYIADRFGRKVCLLATTLT CASLGVLTAVAPDYTSLLIFRLLQGLVSKGSWTAGYTLITEFVGLGYRRTVAILYQMAFT VGLVLLSGLAYILPHWRWLQLAVSLPIFLLLFRFWFVPESPRWLLSQKRNTEAIKIMDHI AQKNGKLPPADLKMLSLEEDVTEKLSPSFIDLFRTPNLRKYTFILMYLWFTSSVVYQGLI MHVGATGGNLYLDFLYSALVEFPAGFIILVTIDRFGRRYPLATSNLAAGLACFLMIFIPH DLPWLNIMVACVGRMGITIVFQMVCLVNAELFPTFIRNLGMMVCSSLCDLGGVLTPFLVF RLMEVWQGSPLILFAALGLVAGGMTLLLPETKGVTLPETIEDAENLQRKAKPKENKIYLQ VQTSELNTQAAERDASQGTAQQK |
| External Links | |
| GenBank ID Protein | AAI51506.1 |
| UniProtKB/Swiss-Prot ID | A7MBE0 |
| UniProtKB/Swiss-Prot Entry Name | S22A1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC151505 |
| GeneCard ID | SLC22A1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |