Showing Protein Serum albumin (BMDBP01370)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01370 |
| Secondary Accession Numbers | None |
| Name | Serum albumin |
| Synonyms | Not Available |
| Gene Name | ALB |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in copper ion binding |
| Specific Function | Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (PubMed:22677715). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (Probable). The rank order of affinity is zinc > calcium > magnesium (Probable). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 6 |
| Locus | Not Available |
| SNPs | ALB |
| Gene Sequence |
>1824 bp ATGAAGTGGGTGACTTTTATTTCTCTTCTCCTTCTCTTCAGCTCTGCTTATTCCAGGGGT GTGTTTCGTCGAGATACACACAAGAGTGAGATTGCTCATCGGTTTAAAGATTTGGGAGAA GAACATTTTAAAGGCCTGGTACTGATTGCCTTTTCTCAGTATCTCCAGCAGTGTCCATTT GATGAGCATGTAAAATTAGTGAACGAACTAACTGAGTTTGCAAAAACATGTGTTGCTGAT GAGTCCCATGCCGGCTGTGAAAAGTCACTTCACACTCTCTTTGGAGATGAATTGTGTAAA GTTGCATCCCTTCGTGAAACCTATGGTGACATGGCTGACTGCTGTGAGAAACAAGAGCCT GAAAGAAATGAATGCTTCCTGAGCCACAAAGATGATAGCCCAGACCTCCCTAAATTGAAA CCAGACCCCAATACTTTGTGTGATGAGTTTAAGGCAGATGAAAAGAAGTTTTGGGGAAAA TACCTATACGAAATTGCTAGAAGACATCCCTACTTTTATGCACCAGAACTCCTTTACTAT GCTAATAAATATAATGGAGTTTTTCAAGAATGCTGCCAAGCTGAAGATAAAGGTGCCTGC CTGCTACCAAAGATTGAAACTATGAGAGAAAAGGTACTAGCTTCATCTGCCAGACAGAGA CTCAGGTGTGCCAGTATTCAAAAATTTGGAGAAAGAGCTTTAAAAGCATGGTCAGTAGCT CGCCTGAGCCAGAAATTTCCCAAGGCTGAGTTTGTAGAAGTTACCAAGCTAGTGACAGAT CTCACAAAAGTCCACAAGGAATGCTGCCATGGTGACCTACTTGAATGCGCAGATGACAGG GCAGATCTTGCCAAGTACATATGTGATAATCAAGATACAATCTCCAGTAAACTGAAGGAA TGCTGTGATAAGCCTTTGTTGGAAAAATCCCACTGCATTGCTGAGGTAGAAAAAGATGCC ATACCTGAAAACCTGCCCCCATTAACTGCTGACTTTGCTGAAGATAAGGATGTTTGCAAA AACTATCAGGAAGCAAAAGATGCCTTCCTGGGCTCGTTTTTGTATGAATATTCAAGAAGG CATCCTGAATATGCTGTCTCAGTGCTATTGAGACTTGCCAAGGAATATGAAGCCACACTG GAGGAATGCTGTGCCAAAGATGATCCACATGCATGCTATTCCACAGTGTTTGACAAACTT AAGCATCTTGTGGATGAGCCTCAGAATTTAATCAAACAAAACTGTGACCAATTCGAAAAA CTTGGAGAGTATGGATTCCAAAATGCGCTCATAGTTCGTTACACCAGGAAAGTACCCCAA GTGTCAACTCCAACTCTCGTGGAGGTTTCAAGAAGCCTAGGAAAAGTGGGTACTAGGTGT TGTACAAAGCCGGAATCAGAAAGAATGCCCTGTACTGAAGACTATCTGAGCTTGATCCTG AACCGGTTGTGCGTGCTGCATGAGAAGACACCAGTGAGTGAAAAAGTCACCAAGTGCTGC ACAGAGTCATTGGTGAACAGACGGCCATGTTTCTCTGCTCTGACACCTGATGAAACATAT GTACCCAAAGCCTTTGATGAGAAATTGTTCACCTTCCATGCAGATATATGCACACTTCCC GATACTGAGAAACAAATCAAGAAACAAACTGCACTTGTTGAGCTGTTGAAACACAAGCCC AAGGCAACAGAGGAACAACTGAAAACCGTCATGGAGAATTTTGTGGCTTTTGTAGACAAG TGCTGTGCAGCTGATGACAAAGAAGCCTGCTTTGCTGTGGAGGGTCCAAAACTTGTTGTT TCAACTCAAACAGCCTTAGCCTAA |
| Protein Properties | |
| Number of Residues | 607 |
| Molecular Weight | 69293.0 |
| Theoretical pI | 6.09 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Serum albumin MKWVTFISLLLLFSSAYSRGVFRRDTHKSEIAHRFKDLGEEHFKGLVLIAFSQYLQQCPF DEHVKLVNELTEFAKTCVADESHAGCEKSLHTLFGDELCKVASLRETYGDMADCCEKQEP ERNECFLSHKDDSPDLPKLKPDPNTLCDEFKADEKKFWGKYLYEIARRHPYFYAPELLYY ANKYNGVFQECCQAEDKGACLLPKIETMREKVLASSARQRLRCASIQKFGERALKAWSVA RLSQKFPKAEFVEVTKLVTDLTKVHKECCHGDLLECADDRADLAKYICDNQDTISSKLKE CCDKPLLEKSHCIAEVEKDAIPENLPPLTADFAEDKDVCKNYQEAKDAFLGSFLYEYSRR HPEYAVSVLLRLAKEYEATLEECCAKDDPHACYSTVFDKLKHLVDEPQNLIKQNCDQFEK LGEYGFQNALIVRYTRKVPQVSTPTLVEVSRSLGKVGTRCCTKPESERMPCTEDYLSLIL NRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSALTPDETYVPKAFDEKLFTFHADICTLP DTEKQIKKQTALVELLKHKPKATEEQLKTVMENFVAFVDKCCAADDKEACFAVEGPKLVV STQTALA |
| External Links | |
| GenBank ID Protein | AAA51411.1 |
| UniProtKB/Swiss-Prot ID | P02769 |
| UniProtKB/Swiss-Prot Entry Name | ALBU_BOVIN |
| PDB IDs | |
| GenBank Gene ID | M73993 |
| GeneCard ID | ALB |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |