| Identification |
|---|
| BMDB Protein ID
| BMDBP01384 |
| Secondary Accession Numbers
| None |
| Name
| Fibroblast growth factor 1 |
| Synonyms
|
Not Available
|
| Gene Name
| FGF1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in growth factor activity |
| Specific Function
| Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| FGF1 |
| Gene Sequence
|
>468 bp
ATGGCTGAAGGAGAAACCACGACCTTCACGGCCCTGACTGAGAAGTTTAACCTGCCTCTA
GGCAATTACAAGAAGCCCAAGCTCCTCTACTGCAGCAACGGGGGCTACTTCCTGAGAATC
CTCCCAGATGGCACAGTGGATGGGACGAAGGACAGGAGCGACCAGCACATTCAGCTGCAG
CTCTGTGCGGAAAGCATAGGGGAGGTGTATATTAAGAGTACGGAGACTGGCCAGTTCTTG
GCCATGGACACCGACGGGCTTTTGTACGGCTCACAGACACCCAATGAGGAATGTTTGTTC
CTGGAAAGGTTGGAGGAAAACCATTACAACACCTACATATCCAAGAAGCATGCAGAGAAG
CATTGGTTCGTTGGTCTCAAGAAGAACGGAAGGTCTAAACTCGGTCCTCGGACTCACTTC
GGCCAGAAAGCCATCTTGTTTCTCCCCCTGCCAGTCTCCTCTGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 155 |
| Molecular Weight
| 17493.0 |
| Theoretical pI
| 7.04 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Heparin-binding growth factor 1
MAEGETTTFTALTEKFNLPLGNYKKPKLLYCSNGGYFLRILPDGTVDGTKDRSDQHIQLQ
LCAESIGEVYIKSTETGQFLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEK
HWFVGLKKNGRSKLGPRTHFGQKAILFLPLPVSSD
|
| External Links |
|---|
| GenBank ID Protein
| CAA31610.1 |
| UniProtKB/Swiss-Prot ID
| P03968 |
| UniProtKB/Swiss-Prot Entry Name
| FGF1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X13221 |
| GeneCard ID
| FGF1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
