| Identification |
|---|
| BMDB Protein ID
| BMDBP01396 |
| Secondary Accession Numbers
| None |
| Name
| Secreted frizzled-related protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SFRP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 27 |
| Locus
| Not Available |
| SNPs
| SFRP1 |
| Gene Sequence
|
>927 bp
ATGGGCGGCGGGCGCTGGGCCGCGGCGGGCGCGCTGCTGGCGCTGGCCGCCGGGCTCCTG
GCCGCGGGCTCGGCCAGCGAGTACGACTACGTGAGCTTCCAGTCGGACATCGGCGCCTAC
CAGAGCGGGCGCTTCTACACCAAGCCACCGCAGTGCGTGGACATCCCGGCAGACCTGCGG
CTGTGCCACAACGTGGGCTACAAGAGGATGGTGCTGCCCAACCTGCTGGAGCACGAGACC
ATGGCCGAGGTGAAGCAGCAGGCCAGCAGCTGGGTGCCCCTGCTCAACAAGAACTGCCAC
ATCGGCACCCAGGTCTTCCTGTGCTCGCTCTTCGCGCCCGTCTGCCTGGACCGGCCCATC
TACCCGTGCCGCTGGCTCTGCGAGGCCGTGCGCGACTCGTGCGAGCCGGTCATGCAGTTC
TTCGGCTTCTACTGGCCCGAGATGCTCAAGTGCGACAAGTTTCCCGAGGGCGACGTCTGC
ATCGCCATGACCCCGCCCAACGCCACCGAGGCCTCCAAGCCCCAAGGCACGACCGTGTGT
CCTCCATGTGACAACGAGCTGAAGTCTGAAGCCATCATTGAGCATCTCTGTGCCAGCGAG
TTTGCCCTGAGGATGAAAATCAAAGAAGTGAAAAAGGAAAACGGCGACAAGAAGATTGTC
CCCAAGAAGAAGAAGCCCCTGAAGCTGGGGCCCATCAAGAAGAAGGAGCTGAAGAAGCTG
GTCCTATACCTGAAGAACGGGGCCGACTGCCCCTGCCACCAGCTGGACAACCTCAGCCAC
CACTTCCTCATCATGGGCCGCAAGGTCAAGAGCCAGTACCTGCTGACCGCCATCCACAAG
TGGGACAAGAAAAACAAGGAGTTCAAGACCTTCATGAAGAAGATGAAGAATCACGAGTGT
CCCACTTTCCAGTCGGTCTTCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 308 |
| Molecular Weight
| 34763.0 |
| Theoretical pI
| 8.99 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Secreted frizzled-related protein 1
MGGGRWAAAGALLALAAGLLAAGSASEYDYVSFQSDIGAYQSGRFYTKPPQCVDIPADLR
LCHNVGYKRMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPI
YPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVC
PPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKL
VLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKTFMKKMKNHEC
PTFQSVFK
|
| External Links |
|---|
| GenBank ID Protein
| AAB67062.1 |
| UniProtKB/Swiss-Prot ID
| O19116 |
| UniProtKB/Swiss-Prot Entry Name
| SFRP1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U85945 |
| GeneCard ID
| SFRP1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
