| Identification |
|---|
| BMDB Protein ID
| BMDBP01399 |
| Secondary Accession Numbers
| None |
| Name
| R-spondin-3 |
| Synonyms
|
Not Available
|
| Gene Name
| RSPO3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in heparin binding |
| Specific Function
| Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| Not Available |
| SNPs
| RSPO3 |
| Gene Sequence
|
>822 bp
ATGCACTTGCGACTGATTTCTTGGTTTTTTATCATTTTGAACTTTATGGAATACATCGGC
AGCCAAAACGCCTCCCGGGGAAGGCGCCAGCGAAGAATGCATCCTAACGTCAGTCAAGGC
TGCCAAGGAGGCTGTGCAACATGTTCAGATTACAATGGATGTTTGTCATGTAAGCCCAAA
CTATTTTTTGTTCTGGAAAGAATTGGCATGAAGCAGATTGGAGTGTGTCTCTCTTCATGT
CCAAGTGGATATTATGGAACCCGATATCCAGATATAAATAAGTGTACAAAATGCAAAGCT
GACTGTGATACCTGTTTCAACAAAAATTTCTGCACAAAGTGTAAAAGTGGATTTTACTTA
CACCTTGGAAAGTGCCTTGACAATTGCCCAGAAGGGTTGGAAGCCAATAACCACACCATG
GAGTGCGTCAGTATTGTGCACTGTGAGGCCAGTGAATGGAGCCCTTGGAGTCCATGCACA
AAGAAAGGAAAAACATGCGGCTTCAAAAGAGGAACTGAAACACGGGTCCGAGAAATAATA
CAGCATCCATCAGCAAAGGGTAACCTGTGTCCCCCCACCAGTGAGGCAAGGAAGTGTACA
GTGCAAAGGAAGAAATGTCCAAAGGGAGAACGAGGAAGAAAAGGAAGGGAGAGAAAAAGA
AAAAAACCTAATAAAGAAGAAAGTAAAGATGCAATACCTGATAACAAAGGTCTGGAGCCC
AGCAGGGAAACTCCAGAGCAACGAGAAAACAAACAGCAGCAGAAGAAACGAAAGGTCCAA
GATAAACAACAGAAGTCGGTATCCGTCAGCACTGTGCACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 273 |
| Molecular Weight
| 31057.0 |
| Theoretical pI
| 9.81 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 75-95
- 167-187
- 203-223
- 228-248
- 253-273
- 289-309
- 356-376
|
| Protein Sequence
|
>R-spondin-3
MHLRLISWFFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPK
LFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL
HLGKCLDNCPEGLEANNHTMECVSIVHCEASEWSPWSPCTKKGKTCGFKRGTETRVREII
QHPSAKGNLCPPTSEARKCTVQRKKCPKGERGRKGRERKRKKPNKEESKDAIPDNKGLEP
SRETPEQRENKQQQKKRKVQDKQQKSVSVSTVH
|
| External Links |
|---|
| GenBank ID Protein
| AAI14714.1 |
| UniProtKB/Swiss-Prot ID
| Q1RMU1 |
| UniProtKB/Swiss-Prot Entry Name
| RSPO3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC114713 |
| GeneCard ID
| RSPO3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
