| Identification |
|---|
| BMDB Protein ID
| BMDBP01405 |
| Secondary Accession Numbers
| None |
| Name
| Apolipoprotein E |
| Synonyms
|
Not Available
|
| Gene Name
| APOE |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell cycle control, cell division, chromosome partitioning |
| Specific Function
| APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| 18q24 |
| SNPs
| APOE |
| Gene Sequence
|
>951 bp
ATGAAGGTTCTGTGGGTTGCCGTGGTGGTCGCGCTTCTGGCAGGATGCCAGGCGGATATG
GAGGGAGAGCTGGGGCCCGAGGAGCCCCTGACTACGCAGCAGCCCCGGGGGAAGGACAGC
CAGCCTTGGGAGCAGGCGCTGGGCCGCTTCTGGGATTACCTGCGCTGGGTGCAGACCCTG
TCTGACCAGGTGCAGGAGGAGCTGCTCAACACCCAGGTCATTCAGGAACTGACGGCGCTG
ATGGAGGAGACCATGAAGGAGGTGAAGGCCTACAAGGAGGAGCTGGAGGGACAGCTAGGC
CCCATGGCCCAGGAGACACAGGCCCGCGTGTCCAAGGAGCTGCAGGCAGCCCAGGCCCGG
CTAGGCTCCGACATGGAGGACTTGCGGAACCGCCTGGCACAGTACCGAAGCGAGGTGCAG
GCCATGCTGGGCCAGTCTACCGAGGAGCTGCGGGCCCGCATGGCCTCCCACCTGCGCAAG
CTGCCGAAGCGGCTGCTCCGCGACGCTGACGACCTGAAGAAGCGCCTGGCCGTCTACCAA
GCTGGGGCCAGCGAGGGTGCCGAGCGCAGCTTGAGCGCCATCCGCGAGCGCTTCGGGCCC
CTGGTGGAGCAGGGCCAATCGCGGGCAGCCACCCTGAGCACCCTGGCCGGCCAGCCGCTG
CTGGAGCGTGCCGAGGCCTGGCGCCAGAAGCTGCACGGGCGCCTGGAGGAGGTGGGCGTC
CGGGCCCAGGACCGCCTGGATAAGATACGCCAGCAGCTAGAGGAGGTGCACGCCAAGGTC
GAGGAGCAGGGCAACCAGATGCGCCTGCAGGCCGAGGCATTCCAGGCCCGCCTCAGGAGC
TGGTTCGAGCCCCTGGTGGAAGACATGCAGCGCCAGTGGGCTGGGCTGGTGGAGAAGGTG
CAGTTGGCTCTGCGCCCCAGCCCCACCTCTCCGCCCAGTGAGAATCATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 316 |
| Molecular Weight
| 35980.0 |
| Theoretical pI
| 5.37 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 48-68
- 70-90
- 116-136
- 144-164
- 194-214
- 247-267
- 301-321
- 338-358
- 371-391
- 395-415
- 439-459
|
| Protein Sequence
|
>Apolipoprotein E
MKVLWVAVVVALLAGCQADMEGELGPEEPLTTQQPRGKDSQPWEQALGRFWDYLRWVQTL
SDQVQEELLNTQVIQELTALMEETMKEVKAYKEELEGQLGPMAQETQARVSKELQAAQAR
LGSDMEDLRNRLAQYRSEVQAMLGQSTEELRARMASHLRKLPKRLLRDADDLKKRLAVYQ
AGASEGAERSLSAIRERFGPLVEQGQSRAATLSTLAGQPLLERAEAWRQKLHGRLEEVGV
RAQDRLDKIRQQLEEVHAKVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKV
QLALRPSPTSPPSENH
|
| External Links |
|---|
| GenBank ID Protein
| CAA46051.1 |
| UniProtKB/Swiss-Prot ID
| Q03247 |
| UniProtKB/Swiss-Prot Entry Name
| APOE_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X64839 |
| GeneCard ID
| APOE |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
