Showing Protein 14-3-3 protein sigma (BMDBP01421)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01421 |
| Secondary Accession Numbers | None |
| Name | 14-3-3 protein sigma |
| Synonyms | Not Available |
| Gene Name | SFN |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in protein domain specific binding |
| Specific Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 2 |
| Locus | Not Available |
| SNPs | SFN |
| Gene Sequence |
>747 bp ATGGAGAGAGCCAGTCTGATCCAGAAGGCCAAGTTGGCCGAGCAGGCCGAACGCTATGAA GACATGGCAGCTTTCATGAAGAGCGCGGTGGAAAAGGGTGAAGAGCTATCCTGCGAAGAG CGCAACCTGCTCTCAGTGGCCTACAAGAACGTGGTGGGTGGCCAGCGGGCGGCGTGGAGG GTCCTGTCCAGTATCGAGCAAAAGAGCAATGAAGAAAGCTCGGAAGAGAAGGGCCCGGAG GTGCAAGAGTACCGGGAGAAGGTGGAGACGGAGCTCCGGGGTGTGTGTGACACAGTGCTG GGCTTGCTGGACACCCACCTCATCAAGGAGGCCGGTGACGCCGAAAGTCGGGTCTTCTAC CTGAAAATGAAGGGCGACTACTACCGCTACCTGGCCGAAGTGGCCACTGGCGACGACAAG AAGCGCATCATCGACTCAGCCCGGTCGGCCTACCAGGAGGCCATGGACATCAGCAAGAAG GAGATGCCGCCCACCAACCCCATCCGCCTGGGCCTGGCCCTGAACTTTTCCGTCTTCCAC TATGAGATCGCCAACAGCCCCGAGGAAGCCATCTCTCTGGCCAAGACCACCTTCGACGAG GCCATGGCCGACCTGCACACCCTCAGCGAGGACTCCTACAAAGACAGCACCCTCATCATG CAGCTGTTGCGAGACAACCTGACGCTGTGGACGGCCGACAACGCCGGGGAAGAAGGGGGC GAGGCTCCCGAGGAGCCCCAGAGCTGA |
| Protein Properties | |
| Number of Residues | 248 |
| Molecular Weight | 27849.0 |
| Theoretical pI | 4.36 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>14-3-3 protein sigma MERASLIQKAKLAEQAERYEDMAAFMKSAVEKGEELSCEERNLLSVAYKNVVGGQRAAWR VLSSIEQKSNEESSEEKGPEVQEYREKVETELRGVCDTVLGLLDTHLIKEAGDAESRVFY LKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFH YEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADNAGEEGG EAPEEPQS |
| External Links | |
| GenBank ID Protein | AAI20374.1 |
| UniProtKB/Swiss-Prot ID | Q0VC36 |
| UniProtKB/Swiss-Prot Entry Name | 1433S_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BC120373 |
| GeneCard ID | SFN |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |