| Identification |
|---|
| BMDB Protein ID
| BMDBP01572 |
| Secondary Accession Numbers
| None |
| Name
| Lysophosphatidic acid receptor 1 |
| Synonyms
|
Not Available
|
| Gene Name
| LPAR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signalin |
| Specific Function
| Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain. |
| Pathways
|
- Lysophosphatidic Acid LPA2 Signalling
- Lysophosphatidic Acid LPA3 Signalling
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| LPAR1 |
| Gene Sequence
|
>1095 bp
ATGGCTGCTGCCTTTACATCCTCCCCTGTCGTTTCACAGCCCCAGTTCACAGCCATGAAC
GAACAACAGTGCTTCTCCAATGAGTCCATCGCCTTCTTTTATAACCGGAGTGGGAAATAT
CTTGCCACAGAATGGAACACAGTCACCAAGCTGGTGATGGGGCTTGGAATCACCGTCTGT
ATCTTCATCATGTTGGCCAACCTCCTGGTCATGGTGGCGATCTATGTCAACCGCCGCTTC
CACTTTCCTATTTATTACCTTATGGCGAATCTGGCTGCTGCGGACTTCTTTGCTGGGTTG
GCCTACTTCTACCTAATGTTCAACACAGGGCCCAATACTCGGAGACTGACTGTCAGCACG
TGGCTCCTGCGTCAGGGCCTCATTGACACCAGCCTGACGGTTTCCGTGGCCAACCTCCTG
GCCATTGCAATTGAGAGGCACATTACAGTTTTCCGTATGCAGCTCCACGCGCGGATGAGC
AATCGGCGAGTGGTGGTGGTGATTGTGGTCATCTGGACCATGGCCATTGTTATGGGGGCT
ATCCCCAGTGTGGGCTGGAACTGCATCTGTGATATTGAAAATTGCTCCAACATGGCGCCC
CTCTACAGCGACTCTTACTTGGTCTTCTGGGCCATTTTCAACTTGGTGACCTTTGTTGTC
ATGGTGGTTCTGTACGCTCATATCTTTGGCTATGTTCGCCAGAGGACTATGAGGATGTCT
CGGCATAGTTCTGGACCCCGACGGAATCGGGATACCATGATGAGTCTTCTGAAGACCGTG
GTCATTGTGCTTGGTGCCTTTATCATCTGCTGGACTCCTGGACTGGTCTTGTTACTTCTC
GACGTGTGCTGCCCCCAGTGTGACGTTCTGGCCTATGAGAAGTTTTTCCTTCTGCTTGCC
GAGTTCAACTCTGCCATGAACCCCATCATCTACTCCTACCGCGACAAGGAGATGAGCGCC
ACCTTCAGGCAGATCCTCTGCTGCCAGCGCAGTGAGAACACCAGCGGCCCGACGGAAGGC
TCGGACCGCTCGGCTTCCTCCCTCAACCACACCATCCTGGCTGGAGTTCACAGCAATGAC
CACTCCGTGGTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 364 |
| Molecular Weight
| 41070.0 |
| Theoretical pI
| 8.6 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 51-75
- 84-107
- 122-144
- 164-184
- 205-225
- 256-280
- 295-315
|
| Protein Sequence
|
>Lysophosphatidic acid receptor 1
MAAAFTSSPVVSQPQFTAMNEQQCFSNESIAFFYNRSGKYLATEWNTVTKLVMGLGITVC
IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST
WLLRQGLIDTSLTVSVANLLAIAIERHITVFRMQLHARMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS
RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA
EFNSAMNPIIYSYRDKEMSATFRQILCCQRSENTSGPTEGSDRSASSLNHTILAGVHSND
HSVV
|
| External Links |
|---|
| GenBank ID Protein
| AAC48695.1 |
| UniProtKB/Swiss-Prot ID
| Q28031 |
| UniProtKB/Swiss-Prot Entry Name
| LPAR1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U48236 |
| GeneCard ID
| LPAR1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
