Identification
BMDB Protein ID BMDBP01582
Secondary Accession Numbers None
Name Radical S-adenosyl methionine domain-containing protein 2
Synonyms Not Available
Gene Name RSAD2
Protein Type Enzyme
Biological Properties
General Function Coenzyme transport and metabolism
Specific Function Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphosphate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cell activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 11
Locus Not Available
SNPs RSAD2
Gene Sequence
>1092 bp
ATGTGGATGCTGGTACCCATTGCGTTTGCTCTCAAGCTGCTGAATGTCTTCCTGCAGCCC
CTGGGCTCTGTGTGGAGCAGCTTGGGGCCCCTGTTCCTCCAGCTCCGTGCAGCATCTTGG
CTGGCAGGGGGCGAGAGGAGCCGGCCGCTCCAGGACAGGAGGGAAGCGGGGGAGCCCGGC
AGGGCGGAGGGAGAGGACGGCGGCGACCTGCCCACCACCCCCACCAGCGTCAATTACCAC
TTCACCCGCCAGTGCAACTACAAGTGTGGCTTCTGCTTCCACACAGCCAAAACGTCCTTC
GTGCTGCCGCTGGAGGAGGCCAAGAAAGGTCTGCTGATGCTGAAAGAAGCAGGTATGGAG
AAGATCAACTTCTCAGGCGGGGAGCCATTCCTCCAGGACCGGGGCGAGTACCTGGGCAGG
CTGGTGAAGTTCTGTAAGCAGGAGCTGCAGCTGCCCAGCGTCAGCATTGTCAGCAACGGG
AGCCTGATCCGCGAGAGGTGGTTCCAGAAGTACGGTGAATATTTGGACATTCTCGCCATC
TCCTGTGACAGCTTTGACGAGCAGGTCAATGTCCTTATTGGCCGTGGTCAAGGAAAGAAG
AACCACGTGGAAAATCTCCAGAAACTGAGGACATGGTGTAAGGAATACAGAGTGGCCTTC
AAGATAAACTCAGTCATCAATCGATTCAACGTGGACGAGGATATGAAGGAACAGATAACC
GCGCTCAACCCCGTCCGCTGGAAGGTCTTCCAGTGTCTCATAATTGAGGGTGAGAACTCT
GGAGAAGATGCTCTGAGAGAAGCGGAACGGTTCGTGATCAGCGACGAGGAGTTTGAAGCG
TTCTTGGATCGCCACAAGGATGTGTCCTGCTTGGTGCCCGAGTCTAACCAGAAGATGAGA
GATTCCTACCTTATTCTGGATGAATATATGCGCTTCCTGAACTGTAGAAATGGGCGGAAG
GATCCTTCCAAGTCCATCTTGGACGTGGGTGTAGAAGAAGCTATAAAATTCAGTGGCTTT
GATGAGAAGATGTTTCTAAAGCGAGGAGGGAAATATGTATGGAGCAAAGCAGACCTGAAG
TTAGACTGGTGA
Protein Properties
Number of Residues 363
Molecular Weight 41672.0
Theoretical pI 6.88
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 30-56
  • 77-98
  • 113-133
  • 140-158
  • 178-200
  • 229-246
  • 288-307
  • 319-338
  • 350-372
Protein Sequence
>Radical S-adenosyl methionine domain-containing protein 2
MWMLVPIAFALKLLNVFLQPLGSVWSSLGPLFLQLRAASWLAGGERSRPLQDRREAGEPG
RAEGEDGGDLPTTPTSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKKGLLMLKEAGME
KINFSGGEPFLQDRGEYLGRLVKFCKQELQLPSVSIVSNGSLIRERWFQKYGEYLDILAI
SCDSFDEQVNVLIGRGQGKKNHVENLQKLRTWCKEYRVAFKINSVINRFNVDEDMKEQIT
ALNPVRWKVFQCLIIEGENSGEDALREAERFVISDEEFEAFLDRHKDVSCLVPESNQKMR
DSYLILDEYMRFLNCRNGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKYVWSKADLK
LDW
GenBank ID Protein AAI05456.1
UniProtKB/Swiss-Prot ID Q2HJF9
UniProtKB/Swiss-Prot Entry Name RSAD2_BOVIN
PDB IDs Not Available
GenBank Gene ID BC105455
GeneCard ID RSAD2
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available