Identification |
BMDB Protein ID
| BMDBP01582 |
Secondary Accession Numbers
| None |
Name
| Radical S-adenosyl methionine domain-containing protein 2 |
Synonyms
|
Not Available
|
Gene Name
| RSAD2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Coenzyme transport and metabolism |
Specific Function
| Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphosphate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cell activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins (By similarity). |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Not Available
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 11 |
Locus
| Not Available |
SNPs
| RSAD2 |
Gene Sequence
|
>1092 bp
ATGTGGATGCTGGTACCCATTGCGTTTGCTCTCAAGCTGCTGAATGTCTTCCTGCAGCCC
CTGGGCTCTGTGTGGAGCAGCTTGGGGCCCCTGTTCCTCCAGCTCCGTGCAGCATCTTGG
CTGGCAGGGGGCGAGAGGAGCCGGCCGCTCCAGGACAGGAGGGAAGCGGGGGAGCCCGGC
AGGGCGGAGGGAGAGGACGGCGGCGACCTGCCCACCACCCCCACCAGCGTCAATTACCAC
TTCACCCGCCAGTGCAACTACAAGTGTGGCTTCTGCTTCCACACAGCCAAAACGTCCTTC
GTGCTGCCGCTGGAGGAGGCCAAGAAAGGTCTGCTGATGCTGAAAGAAGCAGGTATGGAG
AAGATCAACTTCTCAGGCGGGGAGCCATTCCTCCAGGACCGGGGCGAGTACCTGGGCAGG
CTGGTGAAGTTCTGTAAGCAGGAGCTGCAGCTGCCCAGCGTCAGCATTGTCAGCAACGGG
AGCCTGATCCGCGAGAGGTGGTTCCAGAAGTACGGTGAATATTTGGACATTCTCGCCATC
TCCTGTGACAGCTTTGACGAGCAGGTCAATGTCCTTATTGGCCGTGGTCAAGGAAAGAAG
AACCACGTGGAAAATCTCCAGAAACTGAGGACATGGTGTAAGGAATACAGAGTGGCCTTC
AAGATAAACTCAGTCATCAATCGATTCAACGTGGACGAGGATATGAAGGAACAGATAACC
GCGCTCAACCCCGTCCGCTGGAAGGTCTTCCAGTGTCTCATAATTGAGGGTGAGAACTCT
GGAGAAGATGCTCTGAGAGAAGCGGAACGGTTCGTGATCAGCGACGAGGAGTTTGAAGCG
TTCTTGGATCGCCACAAGGATGTGTCCTGCTTGGTGCCCGAGTCTAACCAGAAGATGAGA
GATTCCTACCTTATTCTGGATGAATATATGCGCTTCCTGAACTGTAGAAATGGGCGGAAG
GATCCTTCCAAGTCCATCTTGGACGTGGGTGTAGAAGAAGCTATAAAATTCAGTGGCTTT
GATGAGAAGATGTTTCTAAAGCGAGGAGGGAAATATGTATGGAGCAAAGCAGACCTGAAG
TTAGACTGGTGA
|
Protein Properties |
Number of Residues
| 363 |
Molecular Weight
| 41672.0 |
Theoretical pI
| 6.88 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
- 30-56
- 77-98
- 113-133
- 140-158
- 178-200
- 229-246
- 288-307
- 319-338
- 350-372
|
Protein Sequence
|
>Radical S-adenosyl methionine domain-containing protein 2
MWMLVPIAFALKLLNVFLQPLGSVWSSLGPLFLQLRAASWLAGGERSRPLQDRREAGEPG
RAEGEDGGDLPTTPTSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKKGLLMLKEAGME
KINFSGGEPFLQDRGEYLGRLVKFCKQELQLPSVSIVSNGSLIRERWFQKYGEYLDILAI
SCDSFDEQVNVLIGRGQGKKNHVENLQKLRTWCKEYRVAFKINSVINRFNVDEDMKEQIT
ALNPVRWKVFQCLIIEGENSGEDALREAERFVISDEEFEAFLDRHKDVSCLVPESNQKMR
DSYLILDEYMRFLNCRNGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKYVWSKADLK
LDW
|
External Links |
GenBank ID Protein
| AAI05456.1 |
UniProtKB/Swiss-Prot ID
| Q2HJF9 |
UniProtKB/Swiss-Prot Entry Name
| RSAD2_BOVIN |
PDB IDs
|
Not Available |
GenBank Gene ID
| BC105455 |
GeneCard ID
| RSAD2 |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| Not Available |