| Identification |
|---|
| BMDB Protein ID
| BMDBP01590 |
| Secondary Accession Numbers
| None |
| Name
| ADP-ribosylation factor-like protein 3 |
| Synonyms
|
Not Available
|
| Gene Name
| ARL3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| ARL3 |
| Gene Sequence
|
>549 bp
ATGGGCTTACTCTCAATTCTGCGCAAATTGAAAAGTGCACCAGACCAGGAGGTGAGAATC
CTTCTCCTGGGCTTGGATAATGCTGGCAAGACCACTCTTCTGAAGCAGCTGGCATCTGAA
GACATCAGCCACATCACACCGACGCAGGGTTTTAACATCAAAAGTGTACAATCACAAGGT
TTTAAACTGAATGTCTGGGACATTGGCGGACAGAGGAAAATCAGACCATACTGGAGGAAT
TATTTTGAAAACACTGATATTCTTATATATGTAATTGACAGCGCAGACAGAAAAAGATTT
GAAGAGACAGGTCAGGAACTAGCTGAATTACTGGAGGAAGAAAAGCTAAGTTGCGTGCCC
GTGCTCATCTTTGCTAATAAGCAGGATCTGCTCACAGCAGCCCCTGCCTCTGAAATTGCA
GAAGGACTGAACCTGCACACCATCCGCGACCGATTCTGGCAGATCCAGTCTTGCTCAGCT
CTCACAGGAGAGGGCGTTCAGGACGGCATGAACTGGGTCTGCAAAAATGTCAGCGCAAAG
AAGAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 182 |
| Molecular Weight
| 20505.0 |
| Theoretical pI
| 7.35 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>ADP-ribosylation factor-like protein 3
MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQG
FKLNVWDIGGQRKIRPYWRNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLSCVP
VLIFANKQDLLTAAPASEIAEGLNLHTIRDRFWQIQSCSALTGEGVQDGMNWVCKNVSAK
KK
|
| External Links |
|---|
| GenBank ID Protein
| AAI09566.1 |
| UniProtKB/Swiss-Prot ID
| Q2TBW6 |
| UniProtKB/Swiss-Prot Entry Name
| ARL3_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC109565 |
| GeneCard ID
| ARL3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
