| Identification |
|---|
| BMDB Protein ID
| BMDBP01593 |
| Secondary Accession Numbers
| None |
| Name
| Ras GTPase-activating protein-binding protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| G3BP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| G3BP1 |
| Gene Sequence
|
>1398 bp
ATGGTTATGGAGAAGCCTAGTCCCCTGCTGGTCGGGCGGGAATTTGTGAGACAGTATTAC
ACACTGTTGAACCAGGCCCCAGACATGCTACACAGGTTTTATGGAAAGAACTCTTCTTAT
GTCCATGGGGGATTGGATTCAAATGGAAAGCCAGCAGATGCTGTCTATGGACAGAAAGAA
ATCCATAGGAAAGTGATGTCACAAAACTTCACCAATTGCCACACTAAGATCCGCCACGTT
GATGCTCATGCTACTCTGAATGACGGTGTGGTGGTCCAGGTGATGGGCTTGCTCTCTAAT
AACAACCAGGCTTTGAGGAGATTCATGCAGACCTTTGTCCTTGCTCCTGAGGGCTCTGTT
GCAAATAAGTTCTATGTTCACAATGATATCTTCAGATACCAAGATGAGGTCTTTGGTGGC
TTTATCACTGAACCTCAGGAGGAATCTGAAGAAGAAGTAGAGGAGCCTGAAGAAAGACAG
CAGACACCTGAGGTGGTACCTGATGATTCTGGAACTTTTTATGATCAAACTGTCAGCAAT
GACTTAGAAGAACATTTAGAAGAACCTGTTGCTGAACCAGAGCCTGAACCGGAACCAGAA
CCAGAGCAGGAACCTGTATCTGAAGTCCAGGAGGAAAAGTCTGAGCCAGTCTTGGAAGAA
ACTGCTCCTGAGGATGTTCAGAAGAGTTCTTCTCCAGCACCAGCAGACATAGCCCAGACA
GTGCAGGAGGACTTGAGAACCTTTTCTTGGGCATCTGTGACCAGTAAGAACCTTCCACCC
AGTGGAGCTGTTCCAGTTACTGGGATACCCCCACATGTTGTTAAAGTACCAGCTTCACAG
CCTCGCCCGGAGTCTAAGCCTGAATCTCAGATTCCACTTCAGAGGCCTCAGAGGGATCAG
AGGGTGCGAGAACAGCGAATAAATGTTCCTCCCCAGAGGGGACCCAGACCAGTCCGTGAA
GCTGGTGAGCAAGGCGATGTGGAACCCCGAAGAATTGTGAGACACCCTGACAGTCACCAG
CTCTTCATTGGCAACCTGCCTCATGAGGTGGATAAATCAGAGCTTAAAGACTTTTTTCAA
AATTATGGGAATGTGGTAGAACTGCGTATTAACAGTGGTGGGAAATTACCCAATTTTGGG
TTTGTTGTGTTTGATGATTCTGAGCCTGTTCAGAAGGTGCTTAGCAACAGGCCCATCATG
TTCAGAGGAGAGGTCCGTCTGAACGTGGAAGAAAAGAAGACTCGAGCTGCCCGTGAAGGG
GACCGCCGGGATAACCGCCTGCGGGGACCTGGAGGCCCTCGAGGTGGGCTGGGTGGTGGC
ATGAGAGGCCCACCTCGTGGAGGCATGGTGCAGAAACCAGGATTTGGAGTGGGCAGGAGC
ATTGCTCCAAGGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 465 |
| Molecular Weight
| 52122.0 |
| Theoretical pI
| 5.21 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ras GTPase-activating protein-binding protein 1
MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE
IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV
ANKFYVHNDIFRYQDEVFGGFITEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQTVSN
DLEEHLEEPVAEPEPEPEPEPEQEPVSEVQEEKSEPVLEETAPEDVQKSSSPAPADIAQT
VQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPLQRPQRDQ
RVREQRINVPPQRGPRPVREAGEQGDVEPRRIVRHPDSHQLFIGNLPHEVDKSELKDFFQ
NYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAAREG
DRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRSIAPRQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI09646.1 |
| UniProtKB/Swiss-Prot ID
| Q32LC7 |
| UniProtKB/Swiss-Prot Entry Name
| G3BP1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC109645 |
| GeneCard ID
| G3BP1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
