| Identification |
|---|
| BMDB Protein ID
| BMDBP01605 |
| Secondary Accession Numbers
| None |
| Name
| Claudin-16 |
| Synonyms
|
Not Available
|
| Gene Name
| CLDN16 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in identical protein binding |
| Specific Function
| Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q31-q33 |
| SNPs
| CLDN16 |
| Gene Sequence
|
>765 bp
ATGGGCCCAGGGCTGGCAGCTTCCCATGTGTCCTTTCCAGACAGTCTGCTCGCTAAGATG
AGGGATCTTCTTCAGTATGTTGCCTGCTTCTTTGCTTTTTTCTCCGCTGGGTTCTTGGTT
GTGGCCACCTGGACAGACTGTTGGATGGTGAATGCAGATGACTCCCTGGAGGTGAGCACA
AAATGCCGAGGCCTCTGGTGGGAGTGTGTCACAAATGCTTTTGATGGAATTCGCACCTGT
GATGAGTATGATTCTATACTTGCTGAGCACTCCTTGAAGCTGGTGGTAACTCGGGCGCTG
ATGATTACTGCAGATATTCTAGCTGGATTTGGATTTATTACTCTGCTCCTTGGACTTGAC
TGCGTGAAATTCCTCCCTGATGAGCCATACATCAAAGTCCGCATCAGCTTTGTTGCTGGA
ACCACGTTACTAATAGCAGGTGCCCCAGGAATAATTGGCTCTGTTTGGTATGCTGTTGAT
GTTTATGTAGAACGTTCTTCTCTGGTTTTGCACAATATATTTCTTGGCATCCAATATAAA
TTTGGTTGGTCCTGTTGGCTTGGAATGGCTGGTTCTTTGGGTTGTTTTTTGGCTGGTGCT
ATCCTCACATGCTGCTTATACCTGTTCAAAGATGTTGGACCTGAGAGGAGCTATCCTTAT
TCCACAAGGAAAGCCTATTCAACAACAGCTGTTTCCATGCCCCGGTCACATGCGATCCCT
CGAACACAGACTGCCAAAATGTATGCTGTCGACACCAGGGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 254 |
| Molecular Weight
| 27992.0 |
| Theoretical pI
| 6.86 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 23-43
- 99-119
- 135-155
- 189-209
|
| Protein Sequence
|
>Claudin-16
MGPGLAASHVSFPDSLLAKMRDLLQYVACFFAFFSAGFLVVATWTDCWMVNADDSLEVST
KCRGLWWECVTNAFDGIRTCDEYDSILAEHSLKLVVTRALMITADILAGFGFITLLLGLD
CVKFLPDEPYIKVRISFVAGTTLLIAGAPGIIGSVWYAVDVYVERSSLVLHNIFLGIQYK
FGWSCWLGMAGSLGCFLAGAILTCCLYLFKDVGPERSYPYSTRKAYSTTAVSMPRSHAIP
RTQTAKMYAVDTRV
|
| External Links |
|---|
| GenBank ID Protein
| BAA82553.1 |
| UniProtKB/Swiss-Prot ID
| Q9XT98 |
| UniProtKB/Swiss-Prot Entry Name
| CLD16_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB030082 |
| GeneCard ID
| CLDN16 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
