| Identification |
|---|
| BMDB Protein ID
| BMDBP01616 |
| Secondary Accession Numbers
| None |
| Name
| Collectin-12 |
| Synonyms
|
Not Available
|
| Gene Name
| COLEC12 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Secondary metabolites biosynthesis, transport and catabolism |
| Specific Function
| Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 24 |
| Locus
| Not Available |
| SNPs
| COLEC12 |
| Gene Sequence
|
>2229 bp
ATGAAAGACGATTTTGCAGAGGAGGAGGAGGTACATTCCTTCGGTTACAAGCGGTTTGGT
ATTCAAGAAGGAACACAATGTACCAAATGTAAAAATAATTGGGCACTGAAGCTTTCTATC
ATACTGTTATACATTTTGTGTGCCTTGCTTACCATCACAGTAGCCATTTTGGGATACAAA
GTTGTAGAGAAAATGGACAATGTTACAGGTGGCATGGAGACATCTCGCCAAACCTATGAT
GACAAGCTCACAGCAGTGGAAAGCGACCTGAAAAAATTAGGGGACCAAACAGGAAAGAAA
GCGCTCAGCACCAACTCAGAACTCTCCACCTTCAGGTCGGACATCCTGGATCTCCGTCAG
CAACTTCGTGAGATCACAGAAAAGACCAGCAAGAACAAAGATACGCTGGAGAAGTTACAG
GCAAGCGGGGACGCGCTGGTGGACCGGCAGAGCCAACTGAAGGAAACTTTGGAGAATAAC
TCCTTCCTCATCACCACTGTCAACAAAACCCTGCAGGCGTATAACGGCTACGTCACGAAT
CTTCAGCAGGACACAAGCGTGCTGCAGGGCAACCTGCAGAGCCAAATGTACTCTCACAAC
GTGGTCATCATGAACCTCAACAATCTGAACCTAACCCAGGTGCAGCAGAGGAACCTCATC
ACGAATCTGCAGCGCTCCGTGGATGACACGAGCCAGGCGATCCAGCGCATCAAGAACGAC
TTCCAGAACCTACAGCAGGTCTTCCTTCAAGCCAAGAAGGACACGGACTGGCTGAAGGAG
AAGGTGCAGAGCCTGCAGACGCTGGCTGCCAATAACTCCGCCTTGGCCAAAGCCAACAAC
GACACCCTGGAGGACATGAACAGCCAGCTCAGCTCCTTCACAGGGCAGATGGACAATATC
ACCACAGCCTCCCAAGCCAACGAGCAGAACCTGAAGGACCTGCAGGACGTACACAGGGAT
GCGGAGAACAGAACGGCGGCCAAATTCAGCCAACTCGAGGAGCGCTTCCAGCTCTTTGAG
TCAGACATTGTGAACATCATCAGCAATATCAGCTACACAGCCCACTACCTGCGGACGCTG
ACCAGCAACCTGAACGAAGTCAGGACCACGTGCACAGACACACTGACCAAACACACGGAC
GATCTGACCTCCCTGAACAACACGCTGGCCAACATCCGTTTGGATTCTGTTTCTCTCAGG
ATGCAGCAAGATTTGATGAGGTCGAGGTTGGACACGGAAGTGGCCAACTTGTCAGTGATT
ATGGAAGAAATGAAGCTGGTAGACTCCAAGCATGGTCAGCTCATCAAGAATTTTACCATC
CTGCAAGGTCCTCCTGGCCCCAGGGGTCCAAAAGGTGACCGAGGACAGCAGGGACCCCCA
GGCCCCACCGGCAACAAGGGGCAGAAAGGAGAGAAGGGGGAGCCGGGCCCGCCTGGCCCA
GCCGGTGAGAGGGGCCCAATCGGGCCGGTCGGCCCCCCTGGAGAGCGCGGCAGCAAAGGC
TCCAAAGGCCTGCAAGGCTCCAAAGGCTCCCGAGGGTCTCCTGGGAAGCCCGGCCCCCAG
GGCCCCAGCGGGGACCCAGGCCCCCCCGGCCCGCCGGGCAAGGATGGACTCCCAGGCCCT
CAGGGCCCCCCCGGCTTCCAGGGACTGCAGGGCACCGTGGGGGAGCCTGGGGTGCCCGGG
CCACGGGGGCTGCCAGGCCTCCCTGGGATGCCGGGCATGCCAGGTATCAAGGGTCCCCCT
GGTCCCCCGGGCCCCTCAGGGGCGGCAGTGCCCCTGGCCCTTAAGACTGAGCCGACCACA
GCACCTGAGGACAACGGCTGCCTGCCTTACTGGAAGAACTTCACAGACAAATGCTACTAT
TTTTCAACTGAGAGAGACTTTTTTGAGGATGCAAAACTTTTCTGCGAAAGAATGTCTTCA
CATCTCGTTTTCATAAACACGGGAGAGGAGCAGCAATGGATCAAAAACCAGATGGTGGCG
AAACAGAACTACTGGATTGGCCTCACGGACTTGGAGCAGGAGAATGAATGGAGGTGGCTG
GATGGGACACTTCTGGAGTACAAAAATTGGAAAGCTGGACAGCCAGATAACTGGGGTCAT
GGCCACGGGCCTGGAGAAGATTGCGCTGGACTGATTAATTTTGGGCAGTGGAACGATTTC
CCATGTGAAGACATGAATCACTTCATCTGCGAGAAAGACAGGGAGAGAGAATTAGCAATT
ACATTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 742 |
| Molecular Weight
| 81751.0 |
| Theoretical pI
| 5.29 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Collectin-12
MKDDFAEEEEVHSFGYKRFGIQEGTQCTKCKNNWALKLSIILLYILCALLTITVAILGYK
VVEKMDNVTGGMETSRQTYDDKLTAVESDLKKLGDQTGKKALSTNSELSTFRSDILDLRQ
QLREITEKTSKNKDTLEKLQASGDALVDRQSQLKETLENNSFLITTVNKTLQAYNGYVTN
LQQDTSVLQGNLQSQMYSHNVVIMNLNNLNLTQVQQRNLITNLQRSVDDTSQAIQRIKND
FQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDTLEDMNSQLSSFTGQMDNI
TTASQANEQNLKDLQDVHRDAENRTAAKFSQLEERFQLFESDIVNIISNISYTAHYLRTL
TSNLNEVRTTCTDTLTKHTDDLTSLNNTLANIRLDSVSLRMQQDLMRSRLDTEVANLSVI
MEEMKLVDSKHGQLIKNFTILQGPPGPRGPKGDRGQQGPPGPTGNKGQKGEKGEPGPPGP
AGERGPIGPVGPPGERGSKGSKGLQGSKGSRGSPGKPGPQGPSGDPGPPGPPGKDGLPGP
QGPPGFQGLQGTVGEPGVPGPRGLPGLPGMPGMPGIKGPPGPPGPSGAAVPLALKTEPTT
APEDNGCLPYWKNFTDKCYYFSTERDFFEDAKLFCERMSSHLVFINTGEEQQWIKNQMVA
KQNYWIGLTDLEQENEWRWLDGTLLEYKNWKAGQPDNWGHGHGPGEDCAGLINFGQWNDF
PCEDMNHFICEKDRERELAITL
|
| External Links |
|---|
| GenBank ID Protein
| AAI49194.1 |
| UniProtKB/Swiss-Prot ID
| A6QP79 |
| UniProtKB/Swiss-Prot Entry Name
| COL12_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC149193 |
| GeneCard ID
| COLEC12 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
