| Identification |
|---|
| BMDB Protein ID
| BMDBP01619 |
| Secondary Accession Numbers
| None |
| Name
| Thioredoxin reductase-like selenoprotein T |
| Synonyms
|
Not Available
|
| Gene Name
| SELENOT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in selenium binding |
| Specific Function
| Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (By similarity). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| Not Available |
| SNPs
| SELENOT |
| Gene Sequence
|
>414 bp
ATGCGGGTTATTAGCCAGCGGTACCCTGACATCCGCATAGAAGGAGAGAATTACCTCCCT
CAACCAATATATAGACACATAGCATCTTTCCTGTCAGTCTTCAAGCTAGTATTAATAGGC
TTAATAATTGTTGGCAAGGATCCTTTTGCTTTCTTTGGCATGCAAGCTCCTAGCATCTGG
CAGTGGGGCCAAGAAAATAAGGTCTATGCATGTATGATGGTATTCTTCTTGAGCAACATG
ATTGAAAACCAGTGTATGTCAACAGGTGCATTTGAGATAACTTTGAATGATGTACCTGTG
TGGTCTAAGTTGGAATCTGGTCACCTTCCATCCATGCAACAGCTGGTTCAAATTCTTGAC
AATGAAATGAAGCTCAACGTGCATATGGATTCAATCCCACACCATCGATCATAG
|
| Protein Properties |
|---|
| Number of Residues
| 195 |
| Molecular Weight
| 22248.0 |
| Theoretical pI
| 8.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Selenoprotein T
MRLLLLLLVAASAVVRSDASANLGGVPGKRLKMQYATGPLLKFQICVSUGYRRVFEEYMR
VISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQW
GQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNE
MKLNVHMDSIPHHRS
|
| External Links |
|---|
| GenBank ID Protein
| AAI49083.1 |
| UniProtKB/Swiss-Prot ID
| A6QP01 |
| UniProtKB/Swiss-Prot Entry Name
| SELT_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC149082 |
| GeneCard ID
| SELENOT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
