| Identification |
|---|
| BMDB Protein ID
| BMDBP01620 |
| Secondary Accession Numbers
| None |
| Name
| Selenoprotein S |
| Synonyms
|
Not Available
|
| Gene Name
| SELENOS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in selenium binding |
| Specific Function
| Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| SELENOS |
| Gene Sequence
|
>567 bp
ATGGAGCGGGACGGGGATCAGCTGTCCGCGCGGCCCACCCTCGAGACCGAGGGGCTGCGT
TTCCTTCACGTCACGGTGGGCTCCCTGCTGGCCACTTACGGCTGGTACATCGTCTTCAGC
TGCATCCTTCTCTACGTGGTGTTTCAGAAGCTTTCCACCCGGTTGAGGGCCTTGAGGCAG
AGGCACTTAGATCAAGCTGCCGCTGCTCTGGAACCTGATATTGTTGTTAAACGACAGGAG
GCTTTAGCAGCTGCTCGTTTGAAAATGCAAGAAGAATTAAATGCACAAGTTGAAAAGCAT
AAAGAGAAATTAAGACAGCTTGAAGAAGAAAAAAGGAGACAGAAGATCGAAATGTGGGAT
AGCATGCAAGAAGGAAAAAGTTATAAAGGAAATACAAGAAAGCCTCAGGAAGAAGACAGT
CCTGGGCCTTCTACTTCATCAGTCATCCCAAAACGAAAATCTGACAGAAAGCCTTTGCGA
GGAGGAGGTTACAATCCTTTGTCTGGTGAAGGTGGTGGAACCTGTTCCTGGAGACCTGGA
CGCAGAGGACCCTCATCTGGTGGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 190 |
| Molecular Weight
| 21385.0 |
| Theoretical pI
| 10.24 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Selenoprotein S
MERDGDQLSARPTLETEGLRFLHVTVGSLLATYGWYIVFSCILLYVVFQKLSTRLRALRQ
RHLDQAAAALEPDIVVKRQEALAAARLKMQEELNAQVEKHKEKLRQLEEEKRRQKIEMWD
SMQEGKSYKGNTRKPQEEDSPGPSTSSVIPKRKSDRKPLRGGGYNPLSGEGGGTCSWRPG
RRGPSSGGUG
|
| External Links |
|---|
| GenBank ID Protein
| AAI12741.1 |
| UniProtKB/Swiss-Prot ID
| Q2KI76 |
| UniProtKB/Swiss-Prot Entry Name
| SELS_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC112740 |
| GeneCard ID
| SELENOS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
