| Identification |
|---|
| BMDB Protein ID
| BMDBP01631 |
| Secondary Accession Numbers
| None |
| Name
| Transforming growth factor beta-1-induced transcript 1 protein |
| Synonyms
|
Not Available
|
| Gene Name
| TGFB1I1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| TGFB1I1 |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 456 |
| Molecular Weight
| 49452.0 |
| Theoretical pI
| 6.89 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Transforming growth factor beta-1-induced transcript 1 protein
MEDLDALLSDLETTTSHMPRSGALKERPPEPLTSPLTQMGPGESSGASGDKDHLYSTVCK
PRSPKPAAPATPPFSSSCGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKETAGEQ
KEDQSEDKKRPSPPPSPSPVLPKPSATSATLELDRLMASLSDFRVQNHLPASGPTPPPVP
SSMSEDTPSPPGPTSKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGR
AWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGLCNQPIRHKMVTALGTH
WHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALW
HPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFH
PDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
|
| External Links |
|---|
| GenBank ID Protein
| AAI04511.1 |
| UniProtKB/Swiss-Prot ID
| Q3MHZ4 |
| UniProtKB/Swiss-Prot Entry Name
| TGFI1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DV813479 |
| GeneCard ID
| TGFB1I1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
