| Identification |
|---|
| BMDB Protein ID
| BMDBP01814 |
| Secondary Accession Numbers
| None |
| Name
| Mitochondrial 2-oxoglutarate/malate carrier protein |
| Synonyms
|
Not Available
|
| Gene Name
| SLC25A11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| SLC25A11 |
| Gene Sequence
|
>945 bp
ATGGCGGCGACGGCGAGTCCCGGGGCTTCTGGGATGGACGGGAAGCCCCGTACCTCCCCT
AAGTCCGTCAAGTTCCTGTTTGGGGGCCTGGCCGGGATGGGAGCTACAGTTTTTGTGCAG
CCCTTGGACCTGGTGAAGAACCGGATGCAGCTGAGTGGGGAAGGAGCCAAGACACGAGAG
TACAAAACCAGCTTCCATGCCCTCATCAGCATCCTGAGGGCAGAAGGGCTTAGGGGCATT
TACACCGGGCTATCAGCTGGCCTGTTGCGCCAGGCCACCTACACTACTACTCGTCTTGGT
ATCTATACTGTGCTGTTTGAGCGCCTGACTGGGGCTGATGGTACACCCCCTGGCTTTCTG
CTGAAGGCTGTGATTGGCATGACTGCAGGTGCAACTGGTGCCTTTGTGGGAACACCAGCT
GAAGTGGCTCTTATCCGCATGACCGCTGATGGCCGGCTTCCAGTTGACCAGCGTCGTGGC
TACAAAAACGTGTTTAATGCCCTGTTTCGAATTGTCCAGGAAGAGGGGGTCCCCACACTA
TGGAGGGGCTGCATCCCTACCATGGCTCGGGCTGTCGTCGTCAACGCTGCCCAGCTTGCC
TCCTACTCCCAGTCCAAGCAGTTTTTACTGGACTCAGGCTACTTCTCTGACAACATCCTG
TGCCACTTCTGTGCTAGCATGATCAGTGGCCTGGTCACCACTGCTGCCTCCATGCCCGTG
GACATTGTCAAGACCCGGATCCAGAACATGCGGATGATTGACGGGAAGCCAGAATACAAG
AATGGGCTGGATGTGCTGGTGAAGGTCGTGCGCTACGAGGGCTTCTTCAGCCTGTGGAAG
GGCTTTACACCATACTATGCCCGCCTGGGCCCCCACACTGTCCTCACTTTCATCTTCTTG
GAGCAGATGAACAAGGCCTACAAGCGTCTCTTCCTCAGTGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 314 |
| Molecular Weight
| 34172.0 |
| Theoretical pI
| 10.35 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 24-42
- 83-101
- 119-140
- 183-202
- 222-240
- 281-300
|
| Protein Sequence
|
>Mitochondrial 2-oxoglutarate/malate carrier protein
MAATASPGASGMDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTRE
YKTSFHALISILRAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFL
LKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPVDQRRGYKNVFNALFRIVQEEGVPTL
WRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPV
DIVKTRIQNMRMIDGKPEYKNGLDVLVKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFL
EQMNKAYKRLFLSG
|
| External Links |
|---|
| GenBank ID Protein
| CAA46906.1 |
| UniProtKB/Swiss-Prot ID
| P22292 |
| UniProtKB/Swiss-Prot Entry Name
| M2OM_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X66115 |
| GeneCard ID
| SLC25A11 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
