Showing Protein Muscarinic acetylcholine receptor M2 (BMDBP01818)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01818 |
| Secondary Accession Numbers | None |
| Name | Muscarinic acetylcholine receptor M2 |
| Synonyms | Not Available |
| Gene Name | CHRM2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Not Available |
| Specific Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 4 |
| Locus | Not Available |
| SNPs | CHRM2 |
| Gene Sequence |
>1398 bp ATGAATAACTCAACAAACTCCTCTAACAATGTGGCTCTGACCAGTCCTTATAAGACATTT GAAGTGGTTTTTATTGTCCTTGTGGCTGGGTCCCTCAGTTTGGTGACCATTATTGGGAAC ATCCTGGTCATGGTCTCCATTAAAGTCAATCGCCACCTCCAGACCGTCAACAATTACTTT TTGTTCAGCTTGGCCTGTGCTGACCTCATCATTGGTGTTTTCTCCATGAACTTGTATACC CTTTACACTGTGATTGGCTACTGGCCTTTGGGACCTGTGGTGTGTGACCTTTGGCTTGCC CTGGACTACGTGGTCAGCAATGCCTCAGTAATGAATCTGCTCATCATCAGCTTCGACAGA TACTTCTGCGTCACGAAACCACTCACTTATCCCGTCAAGCGGACCACAAAAATGGCAGGT ATGATGATCGCAGCTGCCTGGGTCCTCTCCTTTATCCTCTGGGCTCCAGCCATTCTCTTC TGGCAGTTCATCGTAGGGGTGAGAACTGTGGAGGATGGGGAATGCTACATCCAGTTTTTT TCCAATGCGGCTGTCACCTTTGGCACGGCCATTGCAGCCTTCTATTTGCCTGTGATCATC ATGACTGTGTTATACTGGCACATATCCCGGGCCAGTAAGAGCAGGATCAAGAAGGACAAG AAGGAGCCTGTAGCCAATCAAGATCCAGTTTCTCCAAGTCTGGTTCAAGGAAGGATAGTG AAGCCAAACAACAACAACATGCCTGGGAGTGATGATGGCTTGGAGCACAACAAAATCCAG AATGGCAAAACTCCTAGAGATGCTGTAACTGAAAACTGTGTCCAGGGGGAGGAGAAAGAG AGCTCCAATGATTCCACCTCAGTCAGTGCTGTTGCCTCTAATATGAGAGATGATGAAATA ACCCAGGACGAAAACACAGTTTCCACTTCTGTGGGCCATTCCAAAGATGAGAACTCAAAG CAAACATGCATCAAAATTGTCACCAAGACCCCAAAAGGTGACCAATGTACCCCAACTAAT ACCACTGTGGAGCTAGTTGGTTCTTCAGGTCAGAATGGAGATGAAAAACAGAACATCGTT GCTCGCAAGATTGTGAAAATGACTAAGCAGCCTGCCAAAAAGAAGCCTCCTCCTTCCCGG GAAAAGAAGGTGACCCGGACGATCTTGGCTATTCTGTTGGCTTTCATCATCACTTGGGCC CCATACAATGTCATGGTGCTCATTAACACCTTTTGTGCACCCTGCATCCCCAACACAGTG TGGACAATCGGTTATTGGCTCTGTTACATCAATAGCACTATCAACCCTGCCTGCTATGCA CTTTGTAATGCCACCTTCAAGAAGACCTTTAAACACCTTCTCATGTGTCATTATAAGAAC ATAGGCGCTACGAGGTAA |
| Protein Properties | |
| Number of Residues | 465 |
| Molecular Weight | 51613.0 |
| Theoretical pI | 9.08 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
|
| Protein Sequence |
>Muscarinic acetylcholine receptor M2 MNNSTNSSNNVALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYF LFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDR YFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFF SNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIV KPNNNNMPGSDDGLEHNKIQNGKTPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEI TQDENTVSTSVGHSKDENSKQTCIKIVTKTPKGDQCTPTNTTVELVGSSGQNGDEKQNIV ARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTV WTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR |
| External Links | |
| GenBank ID Protein | AAZ81568.1 |
| UniProtKB/Swiss-Prot ID | P41985 |
| UniProtKB/Swiss-Prot Entry Name | ACM2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | DQ154113 |
| GeneCard ID | CHRM2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |