| Identification |
|---|
| BMDB Protein ID
| BMDBP01818 |
| Secondary Accession Numbers
| None |
| Name
| Muscarinic acetylcholine receptor M2 |
| Synonyms
|
Not Available
|
| Gene Name
| CHRM2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| CHRM2 |
| Gene Sequence
|
>1398 bp
ATGAATAACTCAACAAACTCCTCTAACAATGTGGCTCTGACCAGTCCTTATAAGACATTT
GAAGTGGTTTTTATTGTCCTTGTGGCTGGGTCCCTCAGTTTGGTGACCATTATTGGGAAC
ATCCTGGTCATGGTCTCCATTAAAGTCAATCGCCACCTCCAGACCGTCAACAATTACTTT
TTGTTCAGCTTGGCCTGTGCTGACCTCATCATTGGTGTTTTCTCCATGAACTTGTATACC
CTTTACACTGTGATTGGCTACTGGCCTTTGGGACCTGTGGTGTGTGACCTTTGGCTTGCC
CTGGACTACGTGGTCAGCAATGCCTCAGTAATGAATCTGCTCATCATCAGCTTCGACAGA
TACTTCTGCGTCACGAAACCACTCACTTATCCCGTCAAGCGGACCACAAAAATGGCAGGT
ATGATGATCGCAGCTGCCTGGGTCCTCTCCTTTATCCTCTGGGCTCCAGCCATTCTCTTC
TGGCAGTTCATCGTAGGGGTGAGAACTGTGGAGGATGGGGAATGCTACATCCAGTTTTTT
TCCAATGCGGCTGTCACCTTTGGCACGGCCATTGCAGCCTTCTATTTGCCTGTGATCATC
ATGACTGTGTTATACTGGCACATATCCCGGGCCAGTAAGAGCAGGATCAAGAAGGACAAG
AAGGAGCCTGTAGCCAATCAAGATCCAGTTTCTCCAAGTCTGGTTCAAGGAAGGATAGTG
AAGCCAAACAACAACAACATGCCTGGGAGTGATGATGGCTTGGAGCACAACAAAATCCAG
AATGGCAAAACTCCTAGAGATGCTGTAACTGAAAACTGTGTCCAGGGGGAGGAGAAAGAG
AGCTCCAATGATTCCACCTCAGTCAGTGCTGTTGCCTCTAATATGAGAGATGATGAAATA
ACCCAGGACGAAAACACAGTTTCCACTTCTGTGGGCCATTCCAAAGATGAGAACTCAAAG
CAAACATGCATCAAAATTGTCACCAAGACCCCAAAAGGTGACCAATGTACCCCAACTAAT
ACCACTGTGGAGCTAGTTGGTTCTTCAGGTCAGAATGGAGATGAAAAACAGAACATCGTT
GCTCGCAAGATTGTGAAAATGACTAAGCAGCCTGCCAAAAAGAAGCCTCCTCCTTCCCGG
GAAAAGAAGGTGACCCGGACGATCTTGGCTATTCTGTTGGCTTTCATCATCACTTGGGCC
CCATACAATGTCATGGTGCTCATTAACACCTTTTGTGCACCCTGCATCCCCAACACAGTG
TGGACAATCGGTTATTGGCTCTGTTACATCAATAGCACTATCAACCCTGCCTGCTATGCA
CTTTGTAATGCCACCTTCAAGAAGACCTTTAAACACCTTCTCATGTGTCATTATAAGAAC
ATAGGCGCTACGAGGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 465 |
| Molecular Weight
| 51613.0 |
| Theoretical pI
| 9.08 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 22-44
- 59-79
- 97-118
- 139-161
- 184-208
- 387-409
- 418-441
|
| Protein Sequence
|
>Muscarinic acetylcholine receptor M2
MNNSTNSSNNVALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYF
LFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDR
YFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFF
SNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIV
KPNNNNMPGSDDGLEHNKIQNGKTPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEI
TQDENTVSTSVGHSKDENSKQTCIKIVTKTPKGDQCTPTNTTVELVGSSGQNGDEKQNIV
ARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTV
WTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
|
| External Links |
|---|
| GenBank ID Protein
| AAZ81568.1 |
| UniProtKB/Swiss-Prot ID
| P41985 |
| UniProtKB/Swiss-Prot Entry Name
| ACM2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DQ154113 |
| GeneCard ID
| CHRM2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
